Antimicrobial Resistance of Pseudomonas aeruginosa Strains Isolated from Surgical Infections in a 7-Year Period at a General Hospital in Venezuela

Abstract

In our setting, cefepime is most active against strains of P. aeruginosa. In comparison with third-generation cephalosporins, cefepime may be less likely to induce resistance. Surveillance of antimicrobial activity should be done periodically to guide therapy of surgical infections.

Analysis of antibiotic utilization and bacterial resistance changes in a surgical clinic of Clinical Centre, Nis

“…Bacterial resistance is recognized as a major factor determining morbidity, mortality and costs in tertiary hospitals 2,6,7 . Several lines of evidence suggest that there is a causal association between the use of antimicrobial agents and the prevalence of drug resistance in micro‐organisms 8,10,16,17 .…”

“…Rodriguez et al. showed varying rates of resistance by P. aeruginosa isolates: 30·9% to gentamicin, 22·5% to ciprofloxacin, 17·6% to amikacin, 13·6% to imipenem/cilastatin, and 8% to cefepime in Venezuelan surgery hospitals 6 …”

“…Antibiotics are the most frequently used medications in Serbian surgical inpatients. By definition, the term ‘surgical infection’ implies that surgery itself plays a major role in therapy, whereas antibiotics are only supplementary 6 . Antibiotic therapy is an important adjunct to surgical or radiological guided procedures designed to gain control of the infected focus and, for this reason, susceptibility patterns of aetiological agents of those infections are relevant 6 .…”

“…By definition, the term ‘surgical infection’ implies that surgery itself plays a major role in therapy, whereas antibiotics are only supplementary 6 . Antibiotic therapy is an important adjunct to surgical or radiological guided procedures designed to gain control of the infected focus and, for this reason, susceptibility patterns of aetiological agents of those infections are relevant 6 . Many studies have demonstrated geographical differences in antibiotic activity, as well as differences between institutions or even wards within institutions 1,2,5,6 .…”

An Infectious Disease Update on Antibiotics: Emerging Resistance

“…Aztreonam has also been shown to be effective for the treatment of Pseudomonas aeruginosa septic arthritis and osteomyelitis [23]. Aztreonam has been effectively used for the treatment of some multiresistant gram-negative bacteria and some antimicrobial-resistant strains of Pseudomonas aeruginosa [24,25]; however, other investigations have revealed that there are a growing number of aztreonam-resistant strains of Pseudomonas aeruginosa [26].…”