Antimicrobial Resistance Patterns of Gram-Negative Bacteria Isolated from Urine Cultures in Almana General Hospital

Abstract

Urinary tract infections are common both in the community and hospitalized patients. Widespread use of antimicrobial agents often leads to the selection of multi-drug resistant micro-organisms. Acquired or emerging bacterial resistance to one or several antimicrobial agents is a global problem.1,2 Many micro-organisms have become resistant to antimicrobial agents.3 Some bacteria, especially Klebsiella pneumoniae, are showing increasing resistance to cephalosporins. These organisms produce extendedspectrum P-lactamases, which are coded by genes located on transferable plasmids.4 Resistance to the quinolones in strains of E. coli isolated from urine specimens of outpatients is also increasing.5As the pattern of bacterial resistance is constantly changing, monitoring of antimicrobial susceptibilities is important. It provides information on the pathogenic organisms isolated from patients, and assists in choosing the most appropriate empirical antimicrobial therapy. In addition, continuous surveys of antimicrobial resistance are crucial for monitoring changes in this resistance. In this report, we analyze the antimicrobial resistance patterns of bacteria isolated from urine specimens examined at

Antimicrobial susceptibility patterns of community-acquired Gram-negative uropathogens

“…These results are similar to that of Moinzadeh et al (2013) and Kashef et al (2010) but differ from Moinzadeh et al (2013) and Valavi et al (2013) that show nalidixic acid (100%) and ceftriaxon (71.4%). Resistance of K. pneumoniae (96.49%) to ampicillin is nearly similar to the results of the study performed in Arabia during 1999 to 2002 (Kader et al, 2004). Limitation of our study is, not considering ESBL.…”

The €œNEW SETTLERS”: RESULTS OF a BACTERIOLOGICAL SURVEY DURING THE FIRST 6-Months OPERATION PERIOD OF AN INTERNAL MEDICINE WARD IN a TERTIARY HOSPITAL

“…The rates of positive urine cultures vary between 9-12% (Kader et al, 2004;Kenneth and Hyams, 1987). It's important to note that Bacteruria is highly affected by the antibiotic treatment the patient receives; after a treatment course is given, the rate of positive cultures greatly declines, as well as the rationale of obtaining the sample in the first place (Kenneth and Hyams, 1987).…”

The molecular basis of β-lactamase production in Gram-negative bacteria from Saudi Arabia

“…aeruginosa is one of the most commonly isolated pathogens in Saudi hospitals and reports from the Kingdom indicate a steady increase in resistance to relevant antipseudomonal drugs and worrying rates of multidrug resistance, including strains with ESBLs and carbapenemases (Yezli et al, 2014). ESBLs have been found in 3-40 % of clinical P. aeruginosa (Kader et al, 2004;Kader & Angamuthu, 2005) and in, respectively, 59 and 69 % of those that are ceftazidime-resistant and extended-spectrum cephalosporin-non-susceptible AlAgamy et al, 2012). Carbapenem-hydrolysing enzymes have also been documented, including MBLs (Guerin et al, 2005;Al-Agamy et al, 2012;.…”

“…ESBL production is also common. Kader et al (2004) asserted that 37.5 % of the Acinetobacter from urine cultures of patients at their hospital in 1999-2002 were ESBL-producing. While b-lactam resistance appears to be frequent, the underlying mechanisms are little studied in the Kingdom (Table 1).…”