Antimicrobial sodium alginate dressing immobilized with polydopamine-silver composite nanospheres

Liang, Limei; Hou, Tingting; Ouyang, Qianqian; Xie, Lei; Zhong, Saiyi; Li, Puwang; Li, Sidong; Li, Cheng‐Peng

doi:10.1016/j.compositesb.2020.107877

Cited by 71 publications

(32 citation statements)

References 66 publications

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“…Based on Archimedes' principle, the total porosity was determined from the liquid displacement method [6]:…”

Section: Characterizationmentioning

confidence: 99%

“…Such broad applications of BC are attributable to its striking physical and mechanical characters, including high purity, hydrophilicity, crystallinity, biocompatibility, ultrafine fiber diameter (20-100 nm), high water holding capacity, high mechanical properties, broad chemical and physical modifying ability, shapeability, and nano-scaled three-dimensional (3D) network structure [4]. Although numerous materials have been developed to make wound dressings [5][6][7][8][9][10], BC is also a suitable material for wound dressings since it can provide a moist environment which is beneficial for healing [11] and biodegradability is not mandatory in wound dressings. Although providing an effective biological barrier to the wound, the fact that BC has no antibacterial activity limits its applications in clinics.…”

Section: Introductionmentioning

confidence: 99%

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Scalable synthesis of robust and stretchable composite wound dressings by dispersing silver nanowires in continuous bacterial cellulose

Wan

Yang

Wang

et al. 2020

Composites Part B: Engineering

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While silver nanoparticles are widely used to endow materials with antibacterial activity, silver nanowires (AgNWs) have not attracted much attention. Herein, the composites of bacterial cellulose (BC) and AgNWs were prepared through a novel step-by-step in situ biosynthesis which retains the three-dimensional network of BC. The results of water vapor permeability, water uptake rate, and water retention rate showed that the BC/AgNW wound dressings could absorb wound skin exudates and maintain moisture environments. Furthermore, the BC/ AgNW dressings were robust and stretchable. More importantly, the BC/AgNW dressings exhibited sustained release of Ag +. The results from animal tests indicated that the BC/AgNW dressing with 38.4 wt% AgNWs exhibited higher expression levels of cytokeratin-10 and integrin-β4, greater proliferation of keratinocytes and formation of epithelial tissues and greatly improved skin regeneration over the bare BC. We propose that the integrated nanofibrous structure and the excellent and sustained antibacterial activity of AgNWs are responsible for the excellent in vivo wound healing ability and biocompatibility. These results suggest that the BC/AgNW composites have promising application as wound dressings.

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“…Based on Archimedes' principle, the total porosity was determined from the liquid displacement method [6]:…”

Section: Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Scalable synthesis of robust and stretchable composite wound dressings by dispersing silver nanowires in continuous bacterial cellulose

Wan

Yang

Wang

et al. 2020

Composites Part B: Engineering

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“…Signi cant porosity value of 77.30 % (relative to hyaluronic acid/cationized dextran (73 %) and quercetin/duck's feet collagen/hydroxyapatite (76.36 %)) and blood compatibility at concentration of 200 ppm made this NC ideal as a safe wound dressing (Liang et al 2020).…”

Section: Chitosanmentioning

confidence: 99%

Antibacterial and wound healing activities of silver nanoparticles embedded in cellulose compared to other polysaccharides and protein polymers

Alavi

Varma

2021

Cellulose

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The aggregation of silver nanoparticles (AgNPs) in colloidal solution and the oxidative cytotoxicity towards human cells are two major hindrances for their thriving medicinal applications. Their incorporation in natural polymers such as cellulose, chitosan, alginate, collagen, gelatin, silk broin, carrageenan, hyaluronic acid, keratin and starch may be an alluring alternative strategy to sidestep these complications and attaining the advantageous wound dressings. Biocompatibility, bioavailability, biodegradability, and inherent therapeutic properties known for theses polymers, would accelerate the healing of infected chronic wounds. However, the low thermal stability, mechanical strength, rapid biodegradation, and weak washing resistance properties are some of the limitations for these polymers.Herein, recent advances, present challenges and future perspective for AgNPs incorporated nanocomposites (NCs) are discussed to realize ideal antibacterial activities by exploiting the abundant natural biopolymers.

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“…[ 13 ] The latter method is superior in terms of sustained release and prolonged effect. Current antibacterial PVC materials are usually loaded with biocidal nanoparticles (NP) such as chitosan, [ 14 ] copper, [ 15 ] silver, [ 16 ] SiO 2 , [ 17 ] and ZnO. [ 18 ] Although these PVC composites can achieve an excellent reduction of viable bacterial cells in comparison to the untreated PVC, they suffer from high costs, sacrificing the polymer mechanical properties and serious toxicity.…”

Section: Introductionmentioning

confidence: 99%

Improving antibacterial, biocompatible, and reusable properties of polyvinyl chloride via the addition of aluminum alkoxides

Zhang

Dong

et al. 2021

Vinyl Additive Technology

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Global bacterial infections associated with conventional polyvinyl chloride (PVC) medical devices place a heavy burden on healthcare systems and thus it will be desirable if medical devices are made from antimicrobial PVC. There are numerous studies focusing on polymer surface modifications to either leach antimicrobial agents or kill pathogenic microbes upon direct contact. In this work, mannitol fumarate ester‐based aluminum metal alkoxide (MFE‐Al) additive was developed to confer simultaneously improved antibacterial property and enhanced high temperature sterilization resistance of the resultant PVC. Data obtained confirm that the MFE‐Al stabilized PVC sheets significantly inhibit 98% bacterial growth. They also show biocompatibility with cultured H9C2 cardiomyocytes and hemocompatibility in vitro. Dry heat sterilization is generally not suitable for PVC medical wares due to their poor thermal compatibility. Surprisingly, our antimicrobial‐biocompatible PVC can maintain stability at 180°C for 90 min. Such a high thermal stability indicates the MFE‐Al stabilized PVC can endure 90 cycles of dry‐heat sterilization without significant damage. This study may provide a solution to reduce PVC medical waste for a maximum benefit without compromising human health or the environment.

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Antimicrobial sodium alginate dressing immobilized with polydopamine-silver composite nanospheres

Cited by 71 publications

References 66 publications

Scalable synthesis of robust and stretchable composite wound dressings by dispersing silver nanowires in continuous bacterial cellulose

Scalable synthesis of robust and stretchable composite wound dressings by dispersing silver nanowires in continuous bacterial cellulose

Antibacterial and wound healing activities of silver nanoparticles embedded in cellulose compared to other polysaccharides and protein polymers

Improving antibacterial, biocompatible, and reusable properties of polyvinyl chloride via the addition of aluminum alkoxides

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