Antimicrobial Strategies in the Prevention of Dental Caries

Marsh, Phillip

doi:10.1159/000261607

Cited by 56 publications

(35 citation statements)

References 16 publications

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“…The solubility parameter of DCM is 19.8 MPa 0. 5 and that of EtOH is 26.0 MPa 0.5 with respect to Ethyl Cellulose 25) . EC with a solubility parameter of 21.18 MPa 0.5 dissolves in DCM which possesses a similar solubility parameter as well 26) .…”

Section: Discussionmentioning

confidence: 93%

“…Bis-biguanide chlorhexidine (CHX) is widely used in chemical methods and is a representative antimicrobial with broadspectrum antibacterial activity that is known to act against gram-positive/negative germs, aerobic and anaerobic microorganisms, yeast, and fungi 4,5) . Various products containing CHX (e.g., mouthwashes, gels, and varnishes) can be used to prevent dental disease in orthodontic patients 6) .…”

Section: Introductionmentioning

confidence: 99%

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Chlorhexidine-releasing orthodontic elastomerics

Jeon

Choi

Kang

et al. 2015

Dental Materials Journal

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The aim of this study was to identify the best combination of chlorhexidine (CHX) with orthodontic elastomerics for prevention of oral disease in orthodontic patients. We used ethyl cellulose (EC) as the polymer, and experimental groups were divided into five groups according to differences in solvent (i.e., ethanol; EtOH, dichloromethane; DCM). CHX release from the coated elastomerics was evaluated with a UV spectrophotometer and observed by scanning electron microscope (SEM). The antimicrobial release increased over time for 48 h in Group 3 (CDA+EC+30% EtOH/70% DCM), exhibiting the longest sustained-release characteristics (p<0.001). It also showed the highest antimicrobial properties, which was confirmed by inhibition zone testing using S. mutans (p<0.05). All groups were not affected when tensile force was tested in the coated elastomerics. We conclude that the antibacterial effect of CHX can be adjusted according to combinations of polymers and solvents. Group 3 exhibited the best substantivity and antimicrobial properties.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Chlorhexidine-releasing orthodontic elastomerics

Jeon

Choi

Kang

et al. 2015

Dental Materials Journal

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“…The control of dental caries is considered a challenge for dentists. Several approaches are recommended for this control, including tooth brushing, fissure sealants, antiplaque agents and sugar substitutes 12 .…”

Section: Discussionmentioning

confidence: 99%

Effects of oral environment stabilization procedures on counts of Candida spp. in children

Rego

Koga-Ito

Jorge

2003

Pesqui. Odontol. Bras.

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ABSTRACT:The effects of oral environment stabilization procedures on counts of Candida spp. have rarely been discussed, and no conclusive results are found in the literature. The aim of this study was thus to ascertain the effects of oral environment stabilization procedures with glass ionomer and zinc oxide-eugenol cements on counts of Candida spp. in the oral cavity of children. For this purpose, oral rinses of sterile phosphate-buffered saline were initially collected from 30 boys and 30 girls, positive for Candida in the saliva and aged from 4 to 10 years. Data on the initial quantity of CFU/ml of Candida were obtained. Then, the children were randomly divided into two groups and oral environment stabilization procedures were performed using zinc oxide-eugenol cement or glass ionomer cement. One week after the procedures were performed, oral rinses were collected again and final Candida counts were obtained. An expressive reduction in Candida counts was observed in both groups. The zinc oxide-eugenol and glass ionomer cements were efficient in the reduction of Candida counts and statistically significant differences were observed between initial and final counts in both groups. Considering the percentage of reduction, the zinc oxide-eugenol cement presented more favorable results, with a reduction of 70%. A reduction of 46% was observed with the use of the glass ionomer cement. According to the obtained results, we concluded that oral environment stabilization procedures were efficient in reducing Candida spp. counts, especially when the zinc oxide-eugenol cement was employed. DESCRIPTORS:Candida; Zinc oxide-eugenol cement; Glass ionomer cement. RESUMO:O efeito da adequação de meio sobre contagens de Candida spp. na cavidade bucal tem sido pouco discutido e nenhum resultado conclusivo foi encontrado na literatura. Desse modo, o objetivo do presente trabalho foi verificar os efeitos da adequação de meio bucal, utilizando cimento de óxido de zinco e eugenol e cimento de ionômero de vidro, sobre contagens desses microorganismos em crianças. Foram coletados enxágües bucais de 30 meninos e 30 meninas com idades entre quatro e dez anos, positivos para Candida na saliva, obtendo-se a contagem inicial. As crianças foram divididas ao acaso em dois grupos e procedeu-se à adequação de meio utilizando um dos cimentos a serem testados. Uma semana depois, novo enxágüe bucal foi coletado, obtendo-se, dessa forma, a contagem final de Candida spp. Uma redução expressiva nas contagens foi observada em ambos os grupos. Os dois materiais testados foram eficazes na diminuição das contagens de Candida, e diferenças estatisticamente significantes foram observadas entre as contagens inicial e final nos dois grupos. Considerando o percentual de redução, o cimento de óxido de zinco e eugenol apresentou resultados mais favoráveis, promovendo uma redução de 70%, ao passo que para o cimento de ionômero de vidro esse valor foi de 46%. De acordo com os resultados obtidos, concluiu-se que a adequação de meio é um procedimento eficaz na red...

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“…Bis-biguanide chlorhexidine (CHX) is an antimicrobial agent with broad-spectrum antimicrobial activity that is known to be effective at inhibiting Grampositive and Gram-negative, aerobic and anaerobic microorganisms, yeast, and fungi 16) . Furthermore, CHX is widely acknowledged as one of the most effective antimicrobial agents due to its superior antiplaque and antigingivitis effects compared with other antimicrobial agents 17,18) . Based on this background, a previous study developed a local DDS for applying CHX to orthodontic patients as an elastomeric 8,19) .…”

Section: Introductionmentioning

confidence: 99%

Improving the efficacy of chlorhexidine-releasing elastomerics using a layer-by-layer coating technique

Jeon

Jung

Kang

et al. 2017

Dental Materials Journal

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The aims of this study were to identify the optimal concentration of coated orthodontic elastomerics using a layer-by-layer technique that can release chlorhexidine (CHX) as an antimicrobial material, and to measure the physical properties and antimicrobial effects of the coated elastomerics. Ethyl cellulose (EC) was used as the polymer, and five study groups with various combinations of solvents (i.e., ethanol and dichloromethane [DCM]) were included. The coated elastomerics were evaluated with a spectrophotometer to confirm the release of CHX, and their surfaces were observed by SEM. The CHX+EC+DCM group sustained antimicrobial release for the longest period (168 h, p<0.001) and exhibited the largest antimicrobial effect in an inhibition zone test using S. mutans for 7 days (p<0.05). This group had most effective physical properties and antimicrobial effects of coated elastomerics produced using a layerby-layer technique, and so its composition should be considered for use in clinical applications in orthodontics.

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Antimicrobial Strategies in the Prevention of Dental Caries

Cited by 56 publications

References 16 publications

Chlorhexidine-releasing orthodontic elastomerics

Chlorhexidine-releasing orthodontic elastomerics

Effects of oral environment stabilization procedures on counts of Candida spp. in children

Improving the efficacy of chlorhexidine-releasing elastomerics using a layer-by-layer coating technique

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