Antimicrobial Susceptibilities of Group B Streptococci Isolated between 1992 and 1996 from Patients with Bacteremia or Meningitis

Group B Streptococcus (GBS) infection has long been recognized as a frequent cause of morbidity and mortality in newborn infants. The purpose of this study was to determine the colonization rate with GBS and the antibiotic susceptibility profile in pregnant women attending Gynecological clinics in Egypt. One-hundred and fifty vaginal swabs were collected from pregnant women at 35-40 weeks of gestation. In comparison to culture, direct latex agglutination testing revealed 100% sensitivity and 93.75% specificity. Thirty-eight specimens (25.3%) were found to be positive for GBS. Each isolate was tested for susceptibility to penicillin G, ampicillin, cefotaxime, erythromycin, clindamycin and vancomycin. Erythromycin-resistant isolates were further classified by double-disk method. All isolates were susceptible to penicillin G, ampicillin and vancomycin. Resistance to cefotaxime was detected in three isolates (7.89%). Five isolates (13.15%) were resistant to erythromycin and nine isolates (23.68%) were resistant to clindamycin. Four (80%) isolates had constitutive macrolide-lincosamide-Streptogramin(B) resistance (cMLSB(B)) resistance and one (20%) isolate had inducible resistance (iMLS(B)) resistance. GBS colonization was found to be high in our region. Latex agglutination testing and Islam medium are reliable methods to detect GBS in late pregnancy; however, latex agglutination test is rapid and simpler. Penicillin G remains the first choice antibiotic for treatment of GBS infections.

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“…Most other studies have found the same [33][34][35][36]. Penicillin G is the drug of choice when diagnosis is established.…”

Section: Discussionmentioning

confidence: 92%

Vaginal carriage and antibiotic susceptibility profile of group B Streptococcus during late pregnancy in Ismailia, Egypt

Shabayek

Abdalla

Abouzeid³

2009

Journal of Infection and Public Health

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“…Reported frequencies range from 7 to 16% and 3 to 9%, respectively [36,37], although there are geographic variations in resistance rates and prevalence of resistance mechanisms. High rates of erythromycin and clindamycin resistance have, however, only been rarely reported: in one study testing 200 GBS isolates collected from vaginal/ rectal specimens [38], the resistance rate was 54% and 33%, respectively.…”

Section: Macrolide-and Clindamycin-resistant Strainsmentioning

confidence: 95%

Invasive Group B Streptococcal Disease in Non-pregnant Adults

2008

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Streptococcus agalactiae, commonly referred as group B Streptococcus (GBS), is a major cause of neonatal sepsis and infections in pregnant women. However, the number of invasive infections in non-pregnant adults is growing. Elderly patients and those with chronic underlying conditions, such as diabetes mellitus or compromised immune defence, are at increased risk of invasion. The spectrum of clinical manifestations is broad and includes necrotizing fasciitis and toxic shock syndrome. Although, primary bacteremia and skin and soft-tissue infections are the most frequently reported diagnosis. This article reviews the epidemiology, pathogenesis and treatment of invasive GBS disease in non-pregnant adults, with an emphasis on skin and soft-tissue infections.

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“…Recent studies demonstrated that some GBS clinical isolates exhibited intermediate or decreased sensitivity, in vitro, to penicillins [10][11][12]. This decrease in sensitivity to penicillin warrants monitoring of GBS for the possible development of resistance to penicillins.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic resistance and penicillin tolerance in ano-vaginal group B streptococci

Panda

Iruretagoyena

Stiller

et al. 2009

The Journal of Maternal-Fetal & Neonatal Medicine

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The relatively high rates of resistance to four of the 15 antibiotics tested confirm that for women allergic to penicillin and colonised with GBS, antibiotic sensitivities should be determined. We noticed increasing resistance to clindamycin over a 7-year period. Ongoing surveillance of local antibiotic resistance patterns at the institutional level is important in determining optimal prophylaxis as resistance patterns differ between institutions and are increasing.

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Antimicrobial Susceptibilities of Group B Streptococci Isolated between 1992 and 1996 from Patients with Bacteremia or Meningitis

Cited by 112 publications

References 25 publications

Vaginal carriage and antibiotic susceptibility profile of group B Streptococcus during late pregnancy in Ismailia, Egypt

Vaginal carriage and antibiotic susceptibility profile of group B Streptococcus during late pregnancy in Ismailia, Egypt

Invasive Group B Streptococcal Disease in Non-pregnant Adults

Antibiotic resistance and penicillin tolerance in ano-vaginal group B streptococci

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