Antimicrobial susceptibilities of <i>Propionibacterium acnes</i> isolated from patients with acne vulgaris

Ishida, Naoki; Nakaminami, Hidemasa; Noguchi, Norihisa; Kurokawa, Ichiro; Nishijima, Satoshi; Sasatsu, Masanori

doi:10.1111/j.1348-0421.2008.00081.x

Cited by 54 publications

(64 citation statements)

References 16 publications

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“…In the present study the majority of the enrolled patients yielded a positive culture for Propionibacterium spp., which is consistent with previous studies [5,22,23]. Nevertheless, it should be noted that in almost all these studies there are patients with acne that are culture negative for Propionibacteria [5,22,23], which may be attributed to previous or current antimicrobial therapy, or ever-expression of other pathogens in the lesions. In addition, pathogenesis of acne is multi-factorial and the presence of Propionibacterium spp.…”

Section: Discussionsupporting

confidence: 84%

MLST typing of antimicrobial-resistant Propionibacterium acnes isolates from patients with moderate to severe acne vulgaris

et al. 2015

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Section: Discussionsupporting

confidence: 84%

MLST typing of antimicrobial-resistant Propionibacterium acnes isolates from patients with moderate to severe acne vulgaris

et al. 2015

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“…In spite of the high frequency of antibiotic use, however, a low rate of antibiotic-resistant strains (4-20.9%) has been reported in some Japanese studies [20,21,22]. The reason for this has not been well investigated.…”

Section: Discussionmentioning

confidence: 89%

Analysis of Facial Skin-Resident Microbiota in Japanese Acne Patients

et al. 2013

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Objectives: We investigated the facial skin microbiota of Japanese acne patients. Methods: Skin swab samples were obtained from 100 acne patients and 28 healthy controls to evaluate Propionibacterium and Staphylococcus spp. using a culture method. Malassezia spp. were evaluated using a nonculture method. Antibiotic resistance of Propionibacterium spp. was also examined. Results: Acne patients and controls did not show significant differences in Propionibacterium and Staphylococcus spp. populations. However, the number of Malassezia globosa from patients was greater than that from controls. Moreover, the number of Propionibacterium spp. from patients carrying antibiotic-resistant strains was significantly greater than that from patients not carrying them. Conclusions: The present study characterized the facial skin microbiota of Japanese acne patients, suggesting a correlation between acne and quantitative differences in Malassezia microbiota. It was also found that the antibiotic resistance of Propionibacterium spp. may affect its abundance in the skin.

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“…There is widespread resistance in P. acnes due to overuse of topical and systemic antibiotics for treatment of acne vulgaris [3,[8][9][10][11][12][13][14][15][16], as shown in Table 4. Various studies have used different interpretative criteria to estimate the resistance among P. acne strains to different anti-acne drugs.…”

Section: Discussionmentioning

confidence: 99%

In vitro antimicrobial susceptibility patterns of Propionibacterium acnes isolated from patients with acne vulgaris

Biswal

Gaind

Kumar

et al. 2016

J Infect Dev Ctries

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Introduction: Propionibacterium acnes has been implicated in the development of acne vulgaris. Rampant use of topical and systemic antibiotics for acne vulgaris has led to resistance due to selective pressure. This study aimed to determine antibiotic resistance of P. acnes. Methodology: A total of 102 samples were collected from acne lesions and cultured onto sheep's blood agar and brain-heart infusion agar supplemented with 5 g/L glucose and 2 mg/L furazolidone) (BHIg) under aerobic and anaerobic conditions. Species identification was done by conventional methods and the VITEK2 Compact system. The isolates were tested for penicillin, erythromycin, clindamycin, ciprofloxacin, nadifloxacin, and tetracycline by E-test, and minimum inhibitory concentration (MIC) of minocycline was determined by agar dilution on BHIg. MIC results were interpreted as per EUCAST (European Committee on Antimicrobial Susceptibility Testing) and CLSI (Clinical Laboratory Standards Institute) guidelines. Results: P. acnes was the most common anaerobe (66%) isolated. Resistance rates using EUCAST and CLSI breakpoints were 10.6% and 6.1%, 7.6% and 0%, 7.8% and 0% for erythromycin, clindamycin, and minocycline, respectively. Tetracycline resistance was observed in 9.2% isolates irrespective of the interpretative criteria used. MIC50 and MIC90 values for nadifloxacin (0.25 and 1 µg/mL) were found to be twofold lower than those for ciprofloxacin (0.5 and 1 µg/mL). Similarly, MIC50 and MIC90 values for minocycline (0.125 and 0.5 µg/mL) were also two-to threefold lower than those for tetracycline (0.38 and 1 µg/mL). Conclusions: To the best of our knowledge, this is the first study focusing on P. acnes resistance from India.

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Antimicrobial susceptibilities of Propionibacterium acnes isolated from patients with acne vulgaris

Cited by 54 publications

References 16 publications

MLST typing of antimicrobial-resistant Propionibacterium acnes isolates from patients with moderate to severe acne vulgaris

MLST typing of antimicrobial-resistant Propionibacterium acnes isolates from patients with moderate to severe acne vulgaris

Analysis of Facial Skin-Resident Microbiota in Japanese Acne Patients

In vitro antimicrobial susceptibility patterns of Propionibacterium acnes isolated from patients with acne vulgaris

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