Antimicrobial susceptibility of Bordetella avium and Bordetella bronchiseptica isolates

Abstract

Two veterinary pathogens, BordeteUa bronchiseptica and Bordetella avium, were tested for their antimicrobial susceptibilities. Of the 20 antimicrobial agents tested, both species were consistently resistant to penicillin and cefuroxime but susceptible to mezlocillin, piperacillin, gentamicin, amikacin, and cefoperazone.Bordetella bronchiseptica and Bordetella avium are important respiratory pathogens of swine and poultry, respectively. B. bronchiseptica is associated with atrophic rhinitis, a slow erosion of nasal turbinates in the snout. In a 1984 U.S. survey, 69% of midwestern hogs had some degree of atrophic rhinitis (11). B. bronchiseptica has also been isolated from rodents, felines, canines, and humans (2,3,6,7,9).B. avium (formerly Alcaligenes faecalis) is the causative agent of turkey coryza. Infected young turkeys experience oculonasal discharge, tracheal collapse, and decreased weight gains; but mortality is usually low (10). No comprehensive epidemiological studies on the incidence of B. avium infection are available.To date, in vitro antimicrobial susceptibility studies with these two organisms have been conducted with either small numbers of isolates (4) or against panels with limited numbers of antimicrobial agents (1,12 tested against all study isolates at the indicated ranges of concentrations: penicillin, 0.015 to 2.0 ,ug/ml; ampicillin, 0.25 to 16 ,ug/ml; ampicillin-sulbactam, 0.03/0.015 to 16/8 ,ug/ml; ticarcillin, 4 to 64 ,ug/ml; mezlocillin, 2 to 4 ,ug/ml; piperacillin, 1 to 64 ,ug/ml; gentamicin, 1 to 8 ,ug/ml; tobramycin, 1 to 8 ,uglml; amikacin, 2 to 32 ,ug/ml; cephalothin, 1 to 16 ,ug/ml; cefuroxime, 0.5 to 32 ,ug/ml; cefoperazone, 2 to 32 ,ug/ml; ceftazidime, 0.5 to 32 ,ug/ml; cefotaxime, 0.5 to 32 ,ug/ml; ceftriaxone, 0.5 to 32 pug/ml; chloramphenicol, 0.25 to 16 ,ug/ml; erythromycin, 0.12 to 8 ,uglml; rifampin, 0.015 to 4 ,ug/ml; trimethoprim-sulfamethoxazole, 0.5/9.5 to 32/608 ,ug/ mnl; and tetracycline, 0.25 to 16 ,ug/ml.The inoculum was a suspension of the organism in

Antimicrobial susceptibility of Bordetella Avium and Ornithobacterium Rhinotracheale strains from wild and domesticated birds in Hungary

“…The MIC of erythromycin against B. avium isolates obtained in our study was similar to the results obtained by Mortensen et al (1989).…”

“…Resistance to enrofloxacin and gentamicin was consistently high. In another study, B. avium isolates were consistently resistant to penicillin and cefuroxime but susceptible to gentamicin and cefoperazone (Mortensen et al, 1989). Beach et al (2012) observed high or intermediate levels of resistance to the third-generation cephalosporins and ampicillin.…”

Virulence and molecular aspects of Bordetella avium isolated from cockatiel chicks (Nymphicus hollandicus) in Brazil

“…The strains analyzed in this study were susceptible to most of the antimicrobial agents tested, with the exception of tetracycline, lincomycin and sulfadimethoxine. These data are in accordance with the results obtained by Mortensen et al (1989) who evaluated the antimicrobial susceptibility of B. avium and B. bronchiseptica isolates. The turkey isolate showed a wide spectrum of antimicrobial resistance that was comparable to that of the cockatiels isolates, most likely due to the greater selective pressure from the antimicrobial use in commercial flocks.…”

Isolation ofBordetella aviumand NovelBordetellaStrain from Patients with Respiratory Disease

“…Clinicians should be aware that human infections with B. avium may pose some antimicrobial drug treatment challenges. A previous report demonstrated that cultures of B. avium were consistently resistant to penicillin and cefuroxime but susceptible to mezlocillin, piperacillin, gentamicin, amikacin, and cefoperazone (6). Although B. avium has been shown to share several virulence factors with B. pertussis, B. parapertussis, and B. bronchiseptica, it does not carry genes that encode pertussis toxin or adenylate cyclase toxin (7).…”