Antimicrobial susceptibility of clinical isolates of Actinomyces and related genera reveals an unusual clindamycin resistance among Actinomyces urogenitalis strains

Barberis, Claudia; Budia, Mabel; Palombarani, Susana; Rodríguez, Carlos Hernán; Ramírez, María Soledad; Arias, Bárbara; Bonofiglio, Laura; Famiglietti, Ángela; Mollerach, Marta; Almuzara, Marisa; Vay, Carlos

doi:10.1016/j.jgar.2016.11.007

Cited by 41 publications

(25 citation statements)

References 28 publications

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“…Our A. urogenitalis strains were widely susceptible to several classes of antibiotics, as previously reported (15). Actinomyces urogenitalis exhibited low minimal inhibitory concentrations (MIC) to b-lactams, erythromycin, daptomycin, rifampicin, tigecycline, and linezolid ( Table 1).…”

Section: Discussionsupporting

confidence: 76%

“…Actinomyces urogenitalis exhibited low minimal inhibitory concentrations (MIC) to b-lactams, erythromycin, daptomycin, rifampicin, tigecycline, and linezolid ( Table 1). The strain exhibited high MICs to fluoroquinolones, that is, moxifloxacin and ciprofloxacin, as previously reported (3,6,15). In the study by Barberis et al (15), 11 of 11 strains of A. urogenitalis were highly resistant to ciprofloxacin and levofloxacin and 8 of 11 strains resistant to clindamycin, though without the definite resistance mechanism being outlined.…”

Section: Discussionsupporting

confidence: 72%

“…The strain exhibited high MICs to fluoroquinolones, that is, moxifloxacin and ciprofloxacin, as previously reported . In the study by Barberis et al , 11 of 11 strains of A. urogenitalis were highly resistant to ciprofloxacin and levofloxacin and 8 of 11 strains resistant to clindamycin, though without the definite resistance mechanism being outlined. It would appear that A. urogenitalis is very susceptible to a wide range of antibiotics used in treating urinary tract infections.…”

Section: Discussionsupporting

confidence: 69%

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Bacteremia and urogenital infection with Actinomyces urogenitalis following prolonged urinary retention

Holmgaard

Marina

Hansen

et al. 2019

APMIS

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A case of bacteremia with the fastidious bacteria Actinomyces urogenitalis following lengthy urinary retention is reported in a sixty‐year‐old man. In 2013, the first case of bacteremia due to A. urogenitalis was presented, secondary to a tubo‐ovarian abscess following transvaginal oocyte retrieval. To the best of our knowledge, this is the first male bacteremic episode involving A. urogenitalis related to a urinary tract focus. The patient had no prior urogenital medical history. Extensive susceptibility testing was done on isolates from urinary and blood cultures. The organism exhibited fluoroquinolone resistance but was susceptible to most other antibiotics used in the treatment of urinary infections. Due to its unusual growth requirements infections with A. urogenitalis are most likely an underdiagnosed entity.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 72%

Section: Discussionsupporting

confidence: 69%

See 1 more Smart Citation

Bacteremia and urogenital infection with Actinomyces urogenitalis following prolonged urinary retention

Holmgaard

Marina

Hansen

et al. 2019

APMIS

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“…This rare infection was cured with prolonged amoxicillin therapy. Penicillin derivatives are the best treatment for Actinomyces infections (Russo, 2010;Barberis et al, 2017), but the effectiveness of β-lactam therapy in prostatic infections is disputable.…”

Section: Discussionmentioning

confidence: 99%

Repetitive urinary tract infections and two prostatic masses: Prostatic soft tissue infection with Actinomyces neuii

Groeneveld

Veldkamp

Dissel

2019

International Journal of Infectious Diseases

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Actinomyces infection is a tissue destructive, low-grade infection that often resembles malignancy. We report the case of a 70-year-old male with repeated, culture-negative urinary tract infections while intermittently catheterized. At presentation, the patient reported a new episode of urinary tract infection with white discharge in his urine. Transrectal ultrasonography showed two lesions in the prostate, suspect for prostate cancer. However, biopsy did not show cancer, and anaerobic culture grew Actinomyces neuii. A 3-month antibiotic course of amoxicillin eventually cured the infection. This is a case of prostatic soft tissue infection with A. neuii. It is important to consider Actinomyces infection in patients with a non-malignant prostatic mass. Although β-lactam antibiotics do not penetrate the prostate well, the Actinomyces infection was cured by prolonged amoxicillin treatment in this case. It is possible that the tissue damage enhanced the amoxicillin concentration in the infected prostate.

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“…The first report of this organism causing clinical infection was in a case of a large subcutaneous abscess 12. Barberis et al analysed the antimicrobial susceptibility of 113 clinical isolates of actinomyces including eight isolates of A. odontolyticus , finding that all of the isolates were susceptible to penicillin, ceftriaxone, vancomycin and linezolid 13. Once recognised, treatment of these infections requires long courses of parenteral and oral therapy.…”

Section: Discussionmentioning

confidence: 99%

Gossypiboma: a ghastly find

Rico¹,

Krishna

Devlin

et al. 2018

BMJ Case Reports

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A gossypiboma is a mass within a patient’s body comprising a cotton matrix surrounded by a foreign body granuloma. We describe an unusual presentation of a gossypiboma presenting in a 32-year-old man with acute epigastric pain and haematemesis. His surgical history revealed an emergency laparotomy following a road traffic accident 16 years ago. Initial gastroscopy showed extrinsic stomach compression. An abdominal ultrasound scan followed by a CT scan evidenced a large, well-defined, predominantly cystic mass with some solid areas occupying the left hypochondrium. Conservative management with insertion of a percutaneous drain proved to be inefficient. A laparotomy was performed; intraoperatively, the cyst was found to be ruptured and within it, a large surgical gauze was found. This was removed but required a distal pancreatectomy and gastrectomy for complete excision. He was discharged on day 74 of admission with outpatient follow-up.

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Antimicrobial susceptibility of clinical isolates of Actinomyces and related genera reveals an unusual clindamycin resistance among Actinomyces urogenitalis strains

Cited by 41 publications

References 28 publications

Bacteremia and urogenital infection with Actinomyces urogenitalis following prolonged urinary retention

Bacteremia and urogenital infection with Actinomyces urogenitalis following prolonged urinary retention

Repetitive urinary tract infections and two prostatic masses: Prostatic soft tissue infection with Actinomyces neuii

Gossypiboma: a ghastly find

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