Antimicrobial susceptibility of clinical isolates of Acinetobacter baumannii

Susceptibility of the Acinetobacter calcoaceticus–A. baumannii complex to imipenem, meropenem, sulbactam and colistin

“…In our strains, MIC 50 and MIC 90 to imipenem were high (4 and 8 mg/l, respectively), and proved similar to those observed by other authors [26,[31][32][33], although higher than those reported in many studies [23][24][25]27,[34][35][36][37][38]. However, significant discrepancies were found among the various biotypes, with noticeably lower MIC for biotypes 9 and 18 than for biotypes 1 and 2.…”

“…All of these were biotype 1, and a high proportion of strains displayed intermediate susceptibility (33.5%), most of which corresponded also to biotype 1. Consequently the susceptibility of our strains (64.3%), and in particular of those of biotype 1 (51%) was lower than reported by most authors [21,[23][24][25][26][27]. Nevertheless, in a recent multicentre study carried out in Spain [28], 28.1% resistance to imipenem in strains of A. baumannii was reported, which is considerably higher than that in our study.…”

Antimicrobial Susceptibility and Mechanisms of Resistance to Quinolones and β-Lactams in Acinetobacter Genospecies 3

“…Although some reports have been published about the antimicrobial susceptibility of these genospecies, mainly A. baumannii (7,9,16,17,19,21), there are no reports concerning the mechanisms of resistance to antimicrobial agents in Acinetobacter genospecies 3. Thus, we herein analyze the antimicrobial susceptibility and mechanisms of resistance to ␤-lactam antibiotics and quinolones in 15 epidemiologically unrelated clinical isolates of Acinetobacter genospecies 3.…”

Identification of Epidemic Strains of Acinetobacter baumannii by Integrase Gene PCR

“…The majority of infections are of epidemic origin, and treatment has become difficult because many strains are resistant to a wide range of antibiotics, including broad-spectrum ␤-lactams, aminoglycosides, and fluoroquinolones (13,20,24,27). Studies of antibiotic resistance mechanisms in A. baumannii have demonstrated the presence of specific genes located on transferable plasmids and transposons (1,22,26).…”