Antimicrobial susceptibility of Escherichia coli from community-acquired urinary tract infections in Europe: the ECO·SENS study revisited

Kahlmeter, Gunnar; Poulsen, Hanna Odén

doi:10.1016/j.ijantimicag.2011.09.013

Cited by 222 publications

(200 citation statements)

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“…Less than 5% of E. coli strains are resistant to nitrofurantoin, whereas other strains are often resistant to it. The rate of E. coli resistance to fluoroquinolones, even in uncomplicated UTIs, varies between countries with rates reported as 0.5-7.6% in Europe, 45 15% in Korea, 46 and up to 35% in some parts of India. 47 Penicillins and cephalosporins are considered safe during pregnancy, but trimethoprim, sulphonamides, and fluoroquinolones should be avoided.…”

Section: A N T I M I C R O B I a L T H E R A P Ymentioning

confidence: 99%

Recurrent Urinary Tract Infections Management in Women : A Review = الإلتهابات المتكررة للمسالك البولية عند النساء و طرق علاجها : مراجعة

Al‐Badr

Al‐Shaikh

2013

SQUMJ

187

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U rinary tract infections (UTIs) occur more often in women than in men, at a ratio of 8:1. Approximately 50-60% of women report at least one UTI in their lifetime, and one in three will have at least one symptomatic UTI necessitating antibiotic treatment by age 24. [1][2][3] Normally, the urinary tract is sterile, but bacteria may rise from the perianal region, possibly leading to UTI. Pathogens in the bladder may stay silent or can cause irritative symptoms like urinary frequency and urgency, and 8% of women may have asymptomatic bacteriuria. If bacteria enter the blood stream, they could cause severe complications, including septicaemia, shock and, rarely, death. 4,5 The definition of recurrent urinary tract infection (RUTI) is three UTIs with three positive urine cultures during a 12-month period, or two infections during the previous 6 months. [5][6][7][8] This article provides an up-to-date review of the epidemiology, pathophysiology, risk factors, diagnosis, management and prevention of RUTIs in women. Classification of Urinary Tract InfectionsUTIs are classified into 6 categories. The first category is an uncomplicated infection; this is when the urinary tract is normal, both structurally and physiologically, and there is no associated disorder that impairs the host defense mechanisms. The second category is an complicated infection; this is Escherichia coli is the organism that causes UTIs in most patients. Recurrent UTIs (RUTI) are mainly caused by reinfection by the same pathogen. Having frequent sexual intercourse is one of the greatest risk factors for RUTIs. In a subgroup of individuals with coexisting morbid conditions, complicated RUTIs can lead to upper tract infections or urosepsis. Although the initial treatment is antimicrobial therapy, use of different prophylactic regimens and alternative strategies are available to reduce exposure to antibiotics.

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Section: A N T I M I C R O B I a L T H E R A P Ymentioning

confidence: 99%

Recurrent Urinary Tract Infections Management in Women : A Review = الإلتهابات المتكررة للمسالك البولية عند النساء و طرق علاجها : مراجعة

Al‐Badr

Al‐Shaikh

2013

SQUMJ

187

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“…Previous studies during 1999-2012 in many countries such as Russia, 3 Greece, 4 Sweden, 5 and Rwanda 6 found that E. coli was the most common pathogen causing UTIs, and 97.0%, 93.0%, 85.3%, 62.1%, respectively, of the isolated pathogens in these studies were susceptible to nitrofurantoin. In Greece 4 and Rwanda, 6 99.0% and 92.3%, respectively, of the isolated pathogens were susceptible to fosfomycin.…”

Section: Introductionmentioning

confidence: 74%

Nitrofurantoin and Fosfomycin Susceptibility Among Outpatient Uropathogens in a Tertiary Care Center in Southern Thailand

Sangsuwan

Jamulitrat

Phengmak

2018

J Health Sci Med Res

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Abstract:Objective: To document susceptibility to fosfomycin and nitrofurantoin among uropathogens isolated from the Out Patient Department and Emergency Room of Songklanagarind Hospital. Material and Methods: From October 2011 to May 2012, bacteria isolated from urine specimens of outpatients with pyuria were evaluated for susceptibility to nitrofurantoin and fosfomycin. The medical records of the patients were reviewed for uropathogens and other antimicrobial susceptibilities. The urinary tract infections (UTIs) were classified into complicated and uncomplicated. Factors associated with fosfomycin and nitrofurantoin susceptibilities were also studied. Results: The study included 324 patients with positive urine cultures. Complicated UTIs and uncomplicated UTIs were found in 72.8% and 27.2%, respectively. The most common causative uropathogen was Escherichia coli (E. coli) (71.9%) followed by Klebsiella pneumoniae (16.7%). The susceptibility of E. coli to fosfomycin was 98.7%, and the susceptibilities of E. coli, K. pneumoniae, and overall pathogens to nitrofurantoin were 91.0%, 24.1% and 74.1% respectively. Conclusion: The uropathogens in Songklanagarind Hospital have higher susceptibilities to fosfomycin than to nitrofurantoin.

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“…Ülkemizden bildirilen çeşitli çalışmalarda da E.coli % 43 ile % 80.4 arasında değişen oranlar¬da en fazla karşılaşılan ÜSİ etkeni olduğu belirtilmiştir [2,[7][8][9][10][11][12][13]. Kanada ve on altı Avrupa ülkesinin ortak verileri olan ECO-SENS 2000 Projesi'nde de % 79.5 oranı ile E.coli en fazla izole edi¬len etken olarak rapor edilmiştir [11]. Çalışmamız-da E.coli'yi sı¬rasıyla Klebsiella spp., Enterococcus spp., Proteus spp.takip et¬miştir.…”

Section: Discussionunclassified

Distribution of Gram Negative Bacteria and Evaluation of Resistance Profiles

Pamukcuoglu¹

2015

Ann Clin Anal Med

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ÖzetAmaç: Bu çalışmada Afyonkarahisar Devlet Hastanesi poliklinik hastalarının idrar kültürlerinde üreyen Gram negatif etkenlerin dağılımı ve antibiyotik direnç durumunun incelenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmamız-da 2012-2013 yılları arasında hastanemiz mikrobiyoloji laboratuvarına gön-derilen poliklinik hastalarının idrar örnekleri retrospektif olarak incelenmiştir. Üreyen bakteriler konvansiyonel ve/veya otomatik Vitec 2.0 sistemi ile çalı-şılmıştır. Antibiyotik duyarlılıkları Kirby-Bauer disk difüzyon yöntemiyle veya Vitec sistemiyle değerlendirilmiş; Clinical and Laboratory Standards Institute (CLSI) kriterlerine göre yorumlanmıştır. Genişlemiş spektrumlu beta-laktamaz (GSBL) varlığı çift disk sinerji testi (ÇDST) veya otomatik sistem ile araştırıl-mıştır. Bulgular: Çalışmaya poliklinik hastalarından 671 izolat dahil edilmiş-tir. İzole edilen suşların 427'sinin (% 63.6) Escherichia coli, 165'inin (% 24.6) Klebsiella spp., 22'sinin (% 3.3) Pseudomonas spp., dokuzunun (% 1.3) Acinetobacter spp., 41'inin (%6.1) Proteus spp., yedisinin (% 1.0) Serratia spp. olduğu saptanmıştır. E.coli izolatlarının 97'sinde (% 22.8), Klebsiella spp. izolatlarının 41'inde (% 24.8) GSBL pozitifliği izlenmiştir. En sık izole edilen tür olan E.coli için, suşların % 31.1'i trimetoprim-sülfametoksazole, % 16'sı siprofloksasine, % 3.6'sı nitrofrontoine dirençli olarak saptanmıştır. Enterobactericeae suşlarında karbapenem grubu antibiyotiklere direnç saptanmazken, aminoglikozid grubu antibiyotiklere duyarlılık oranı yüksek bulunmuştur. Tartış-ma: Üriner sistem infeksiyonlarının sağaltımında; her geçen gün artan antimikrobiyal direnç oranlarına sahip mikroorganizmaları göz önünde bulundurmak, GSBL üretimini ve direnç gelişimini önlemek için; hastanede yatan hastalarda olduğu gibi ayaktan hastalara da doğru endikasyonda antibiyotik kullanılmasına büyük bir titizlik gösterilmesi, uygunsuz ve gereksiz antibiyotik kullanımından kaçınılması gerekmektedir. Anahtar KelimelerAntimikrobiyal Direnç; E.coli; ESBL; İdrar Kültürü; Enfeksiyon Abstract Aim: In this study, we aimed to examine the distributon of Gram negative bacteria isolated from urine cultures of out-patients in Afyonkarahisar State Hospital and evaluate the antimicrobial resistance rates of these pathogens. Material and Method: Urine samples of out-patients which were sent to microbiology laboratory between 2012-2013 were retrospectively evaluated. The isolates were identified using conventional methods and/or automated Vitec 2.0 system. Antibiogram sensitivities were determined by Kirby-Bauer disc diffusion method or automated system and interpreted on the basis of Clinical and Laboratory Standards Institute (CSI) criteria. Double disc sinergy test (DDST) or Vitec 2.0 system was used to detect extended spectrum betalactamase (ESBL).When conventional methods could't be clarified according to their colony morphologies, gram staining patterns, biochemical test; automated system has been used. Results: A total of 671 isolates acquired from urine samples were studied. 427 Es...

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Antimicrobial susceptibility of Escherichia coli from community-acquired urinary tract infections in Europe: the ECO·SENS study revisited

Cited by 222 publications

References 21 publications

Recurrent Urinary Tract Infections Management in Women : A Review = الإلتهابات المتكررة للمسالك البولية عند النساء و طرق علاجها : مراجعة

Recurrent Urinary Tract Infections Management in Women : A Review = الإلتهابات المتكررة للمسالك البولية عند النساء و طرق علاجها : مراجعة

Nitrofurantoin and Fosfomycin Susceptibility Among Outpatient Uropathogens in a Tertiary Care Center in Southern Thailand

Distribution of Gram Negative Bacteria and Evaluation of Resistance Profiles

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