Antimicrobial susceptibility of Haemophilus influenzae and Moraxella catarrhalis isolates in eight Central, East and Baltic European countries in 2005-06: results of the Cefditoren Surveillance Study

Gracia, Matilde; Díaz, C. Caramelo; Coronel, Pilar; Gimeno, Mercedes; García-Rodas, Rocío; Prado, Gema del; Huelves, Lorena; Ruiz, Vicente Ausina; Naves, Plínio Lázaro Faleiro; Ponte, M.C.; Granizo, Juan José; Soriano, Francisco

doi:10.1093/jac/dkn083

Cited by 15 publications

(10 citation statements)

References 7 publications

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“…Data on the prevalence of BLNAR H. influenzae isolates are variable, but the prevalence is usually low ( ! 10%), although up to 20% have been reported in Poland [19,20,22] . In our study, the ␤ -lactamase production rate was 5.7%, and this was consistent with a recent multicenter study in Turkey performed in 2004-2005 [13] .…”

Section: Discussionmentioning

confidence: 94%

Comparison of in vitro Activities of Tigecycline with Other Antimicrobial Agents against Streptococcus pneumoniae,Haemophilus influenzae and Moraxella catarrhalis in Two University Hospitals in Istanbul, Turkey

Gönüllü

Catal²,

Küçükbasmacı³

et al. 2009

Chemotherapy

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Background: We compared the in vitro activities of tigecycline with those of other agents against 97 Streptococcus pneumoniae, 140 Haemophilus influenzae and54 Moraxella catarrhalis strains isolated in two large university hospitals in Istanbul. Methods: For analysis, the agar dilution method was used. Results: For S. pneumoniae isolates, 32% were not susceptible to penicillin (28.9% intermediate and 3.1% resistant). Cefotaxime, telithromycin, moxifloxacin and linezolid were fully active. Tigecycline had a 90% minimum inhibitory concentration (MIC₉₀) of 0.12 μg/ml. For H. influenzae, 8.57% were not susceptible to ampicillin, among which 8 possessed β-lactamase (5.7%). Four (2.87%) H. influenzae isolates with β-lactamase-negative and ampicillin-resistant phenotype were found. All isolates were susceptible to ceftriaxone, azithromycin, ciprofloxacin, levofloxacin and moxifloxacin. MIC₉₀ for tigecycline was 0.5 μg/ml. Of 54 M. catarrhalis isolates, 88.9% possessed β-lactamase. Tigecycline and fluoroquinolones were highly active (MIC₉₀ ≤0.12 μg/ml). Conclusions: Linezolid, telithromycin, newer fluoroquinolones and tigecycline all have excellent in vitro activities against the 3 respiratory pathogens.

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Section: Discussionmentioning

confidence: 94%

Comparison of in vitro Activities of Tigecycline with Other Antimicrobial Agents against Streptococcus pneumoniae,Haemophilus influenzae and Moraxella catarrhalis in Two University Hospitals in Istanbul, Turkey

Gönüllü

Catal²,

Küçükbasmacı³

et al. 2009

Chemotherapy

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“…26,33,38-43 Cefditoren's activity is comparable to that of the injectable cephalosporins tested and to levofloxacin, while it is higher than that of all the oral beta-lactams. [25][26][38][39][40][41][42][43] Cefditoren has maintained the same level of intrinsic strength against H. influenzae shown in the previous study 26 , independently of the production of beta-lactamases or ampicillin resistance. it should be noted that the increase in resistance to cefaclor compared with the study of 2008 26 confirms the data of Johnson et al, 41 and of more recent observations.…”

Section: Discussionmentioning

confidence: 74%

“…42,43 Our results on the activity of the antibiotics tested against M. catarrhalis are in agreement with the literature data. [11][12][13][25][26]29,38,[40][41][42][43] There has been an increase in MiC values among beta-lactamase-positive and -negative strains for all the beta-lactams. in agreement with the breakpoints suggested for cefditoren, M. catarrhalis should be considered susceptible.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Susceptibility of Respiratory Pathogens Recently Isolated in Italy: Focus on Cefditoren

Tempera

Furneri²,

Carlone³

et al. 2010

Journal of Chemotherapy

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The aim of this study was to evaluate the in vitro antibiotic susceptibility of respiratory pathogens recently isolated in Italy to commonly used antibiotics including cefditoren. Six clinical microbiological laboratories collected, between January and September 2009, a total of 2,510 respiratory pathogens from subjects with community-acquired respiratory tract infections (CARTI). Ceftditoren, out of all the beta-lactams studied, had the lowest MIC(90 )against 965 strains of Streptococcus pneumoniae examined, followed by cefotaxime and ceftriaxone (2% resistance in penicillin-resistant S. pneumoniae (PRSP)). Against 470 Haemophilus influenzae , independently of their production of beta-lactamases or ampicillin resistance, cefditoren was the oral cephalosporin with the best in vitro activity, comparable to that of the injectable cephalosporins and levofloxacin. Higher MIC(90)s were found for the macrolides (4 - 16 mg/l) and cefaclor (4 - 32 mg/l). As was foreseeable, Streptococcus pyogenes (225 strains) was uniformly sensitive to all the beta-lactam antibiotics, but the elevated MIC(90 )values reduced (<75%) susceptibility of this pathogen to macrolides. Beta-lactamase-negative Moraxella catarrhalis (100 strains) had reduced susceptibility only to the macrolides, while the 250 beta-lactamase-producing strains also had reduced susceptibility to cefuroxime. Levofloxacin showed the lowest MIC(50)/MIC(90 )values in the producing strains, whereas cefditoren, cefotaxime and ceftriaxone in the non-producers. As regards the enterobacteriaceae, cefditoren and levofloxacin had the lowest MIC(90)s against Klebsiella pneumoniae. Cefditoren and the third-generation injectable cephalosporins had the lowest MIC(90)s against Escherichia coli (100% susceptibility) while levofloxacin was less active (86% susceptibility).In conclusion, cefditoren's wide spectrum and high intrinsic activity, as well as its capacity to overcome most of the resistance that has become consolidated in some classes of antibiotics widely used as empiric therapy for CARTI, allows us to suggest that cefditoren might be included in the european guidelines as one of the first-choice antibiotics in the treatment of CARTI.

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“…В свою очередь, широкое назначение антибактери-альных препаратов приводит к росту антибиотикорези-стентности [14][15][16][17][18][19].…”

Section: таблица критерии постановки диагноза обрс (Idsa)unclassified

Complex therapy of acute bacterial rinosinusis

Кочетков¹,

Мокоян²

2018

Med. sov.

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Antimicrobial susceptibility of Haemophilus influenzae and Moraxella catarrhalis isolates in eight Central, East and Baltic European countries in 2005-06: results of the Cefditoren Surveillance Study

Cited by 15 publications

References 7 publications

Comparison of in vitro Activities of Tigecycline with Other Antimicrobial Agents against <i>Streptococcus pneumoniae,</i><i>Haemophilus influenzae</i> and <i>Moraxella catarrhalis </i>in Two University Hospitals in Istanbul, Turkey

Comparison of in vitro Activities of Tigecycline with Other Antimicrobial Agents against <i>Streptococcus pneumoniae,</i><i>Haemophilus influenzae</i> and <i>Moraxella catarrhalis </i>in Two University Hospitals in Istanbul, Turkey

Antibiotic Susceptibility of Respiratory Pathogens Recently Isolated in Italy: Focus on Cefditoren

Complex therapy of acute bacterial rinosinusis

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