Antimicrobial susceptibility patterns of &lt;i&gt;E. coli&lt;/i&gt; from clinical sources in northeast Ethiopia

Kibret, Mulugeta; Abera, B

doi:10.4314/ahs.v11i3.70069

Cited by 146 publications

(118 citation statements)

References 23 publications

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“…Antibiotic resistance in E. coli has emerged and increased in many countries and led to the difficult treatment of infectious bacteria (2). In the present study, 62% of human E. coli strains were resistant to tetracycline, which supported the above hypothesis.…”

Section: Discussionsupporting

confidence: 78%

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Patterns of Efflux Pump Genes Among Tetracycline Resistance Uropathogenic Escherichia coli Isolates Obtained From Human Urinary Infections

Gharajalar

Sofiani

2017

Jundishapur J Microbiol

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Background: Uropathogenic Escherichia coli is one of the most prevalent infectious agents in humans, but its resistance to commonly used antibiotics is growing rapidly. Objectives: The aim of this cross sectional study was to investigate the prevalence of tetracycline resistance determinants in urinary E. coli isolates obtained from patients in Iran. Methods: A total of 50 E. coli isolates from human urinary infections were characterized by cultural, biochemical, and molecular tests from 2014 to 2015. Isolates were tested for resistance to tetracycline by disc diffusion method. Then, the prevalence of tetracycline efflux genes (tetA, tetB, tetC, tetD, tetE, tetG, tetH and tetZ) was detected by means of molecular polymerase chain reaction method (PCR). Results: Of the 50 E. coli isolates tested, tetracycline resistance was identified in 62% of the strains. PCR analysis revealed that 36% of these isolates contained tetB gene, followed by tetA determinant with 32% frequency. The prevalence of tetG, tetZ, tetC, tetE, tetH, and tetD were 16%, 14%, 12%, 12%, 11%, and 8% among the isolates. Conclusions: Tetracycline resistance is widespread among uropathogenic E. coli isolates from human infections. Moreover, the distribution of tetracycline resistance determinants among the studied E. coli was very similar to the findings of the international sourced gallery of clinical E. coli Strains.

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Section: Discussionsupporting

confidence: 78%

“…Among the various extraintestinal infections caused by this bacterium, urinary infections are very important in humans (2). Recent reports have indicated that the rate of antibiotic resistance among E. coli isolates is increasing rapidly (3).…”

Section: Introductionmentioning

confidence: 99%

Patterns of Efflux Pump Genes Among Tetracycline Resistance Uropathogenic Escherichia coli Isolates Obtained From Human Urinary Infections

Gharajalar

Sofiani

2017

Jundishapur J Microbiol

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“…A total of 100, 93.33, and 66.66% of the E. coli isolates exhibited resistance to Erythromycin, Cefuroxime and Tetracycline respectively. A similar result was obtained by Kibret and Abera (2011), where Erythromycin and Tetracycline were resistance to 89.4 and 72.6% to E. coli isolates respectively. A study conducted by Ahmed et al (2015) in Islamabad showed complete resistance of E. coli isolates to Cefuroxime.…”

Section: Discussionsupporting

confidence: 72%

Antibiotic sensitivity patterns of microbial isolates from fish ponds: A study in the Greater Accra Region of Ghana

Apenteng¹,

Osei-Asare²,

Oppong³

et al. 2017

Afr. J. Pharm. Pharmacol.

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Intensive use of antimicrobial agents in aquaculture provides a selective pressure creating reservoirs of drug-resistant bacteria and transferable resistance genes in fish pathogens and other bacteria in the aquatic environment. From these reservoirs, resistance genes may disseminate by horizontal gene transfer and reach human pathogens, or drug-resistant pathogens from the aquatic environment may reach humans directly. This study aims at identifying the antibiotic sensitivity patterns of Pseudomonas aeruginosa, Salmonella typhi, and Escherichia coli isolates from fish ponds in two localities (Ashiaman and Dawhenya) in the Greater Accra region of Ghana. A total of 43 isolates were tested using the KirbyBauer agar disc diffusion method against Ciprofloxacin (5 µg), Erythromycin (15 µg), Cefuroxime (30 µg), Gentamicin (10 µg), and Tetracycline (30 µg).P. aeruginosa was the most isolated organism with 90% prevalence, followed by E. coli (75%) and S. typhi (50%). All the P. aeruginosa isolates were resistant to Erythromycin and Cefuroxime while 90% of the S. typhi isolates were resistant to Tetracycline and Erythromycin. E. coli isolates showed 100, 93.33 and 66.66% resistance to Erythromycin, Cefuroxime and Tetracycline respectively. Gentamicin, Tetracycline and Ciprofloxacin were sensitive to 66.66, 61.10 and 50% of P. aeruginosa isolates respectively. Ciprofloxacin was sensitive to 90% of the S. typhi isolates whiles Gentamicin was sensitive to 70% of the S. typhi isolates. Ciprofloxacin and Gentamicin were more sensitive to E. coli isolates (80 and 66.66% sensitivity respectively). Multi-drug resistant strains were obtained in 77.78% of P. aeruginosa and 70% of S. typhi isolates whiles 66.67% of E. coli isolates were also resistant to more than two classes of the antibiotics tested. High levels of microbial resistance were observed in the isolates with 72.09% of isolates being multidrug resistant strains.

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“…The latter is in concomitant with a recent work where both Imipenem and Amikacin were well effective against gram negative bacilli [28]. The E. coli isolates in our specimens showed various degrees of resistance to Ciprofloxacin, Co-trimoxazole, Tetracycline, Gentamicin which is in agreement with a similar study where E. coli resisted to these antibiotics with a slight differences [29]. While all stains of E coli showed resistance against Ceftazidime, Augmentin, Ampicillin, Piperacillin, Cephalothin; however, some stains showed resistance against Cefixime, Azteroname, Chloramphenicol and Cefotaxime.…”

Section: Discussionsupporting

confidence: 81%

Impact of Some Antibiotics on Bacteria Isolated from Appendices in Kirkuk Province, Iraq

Bazzaz¹,

Lor²,

Mahdi³

2018

ABB

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A bacteriological study of 50 appendectomy cases for patients diagnosed by physicians to be appendicitis, within Kirkuk province was carried out to isolate the habitat bacteria of appendix and to assess the impact of some antibiotics on isolated bacterial species from the appendices. The age of patients ranged between 3 -45 year old (21 male and 29 female). The culture results showed 94% single isolate with 2% negative growth and 4% mixed growth were obtained. The gram positive bacteria isolate formed (11.77%) less than gram negative (88.23%). The total isolates represented 51 included Escherichia coli 34 (66.66%), followed by Enterococcus faecalis 3 (5.89%), Klebsiella pneumonia 3 (5.89%), Citrobacter youngae 2 (3.92%), Raultella terrigena 2 (3.92%), Pseudomonas aeruginosa 2 (3.92%), Enterrobacter cloacae 1 (1.96%), Serratia fonticola 1 (1.96%), Entercoccus faecium 1 (1.92%), Staphylococcus epidermides 1 (1.96%) and Staphylococcus xylosus 1 (1.96%). The Staphylococcus xylosus was the first time to be isolated in Kirkuk city while both of Raultella terrigena and Citrobacter youngae were isolated for the first time in appendix samples. Only 16 various antibiotics were tested against Enterobacteriaceae and Pseudomonas aeruginosa while 12 and 7 against Staphylococcus sp. and Enterococcus sp., respectively. The Imipenem and Amikacin were found to be most effective antibiotics against all Enterobacteriaceae isolates and Pseudomonas aeruginosa while Ampicillin, Piperacillin, Ceftazidime, Augmentin, and Cephalothin were ineffective against all isolated bacteria. The Penicillin and Vancomycin were effective against gram positive bacteria.

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Antimicrobial susceptibility patterns of <i>E. coli</i> from clinical sources in northeast Ethiopia

Abstract: Background: Escherichia coli is the leading cause of urinary tract, ear, wound and other infections in humans. Increasing rates of antimicrobial resistance among E. coli is a growing concern worldwide.

Cited by 146 publications

References 23 publications

Patterns of Efflux Pump Genes Among Tetracycline Resistance Uropathogenic Escherichia coli Isolates Obtained From Human Urinary Infections

Patterns of Efflux Pump Genes Among Tetracycline Resistance Uropathogenic Escherichia coli Isolates Obtained From Human Urinary Infections

Antibiotic sensitivity patterns of microbial isolates from fish ponds: A study in the Greater Accra Region of Ghana

Impact of Some Antibiotics on Bacteria Isolated from Appendices in Kirkuk Province, Iraq

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