Antimicrobial terpenoids fromPterocarpus indicus

Abstract

A mixture of loliolide 1 (> 85%) and paniculatadiol 2 (< 15%) was obtained from the ethyl acetate leaf extract of Pterocarpus indicus by silica gel chromatography, while the air-dried flowers afforded lupeol 3 and phytol esters 4. The structures of 1-4 were determined by NMR spectroscopy. Antimicrobial tests on a mixture of 1 and 2 indicated that it has moderate activity against Candida albicans and low activity against Pseudomonas aeruginosa, Escherichia coli, and Aspergillus niger. It was found inactive against Staphylococcus aureus, Bacillus subtilis, and Trichophyton mentagrophytes.

Phytoconstituent screening and antimicrobial principles of leaf extracts of two variants of Morus alba (S30 and S54)

“…Though, alkaloids, phenolic compounds and flavonoids were present in limited amount. Each of this group of compounds has been reported to possess antimicrobial activity (Ragasa et al, 2005;Cuhnie and Lamb, 2006;Soetan et al, 2006) and reportedly exert their effects by affecting the cell membrane integrity of the bacteria (Hendrich, 2006;Trombetta et al, 2005;Killeen et al, 1998).…”

Acute and sub-chronic oral toxicity studies of an aqueous stem bark extract of Pterocarpus soyauxii Taub (Papilionaceae) in rodents

“…Roxb-(−)-epicatechin, a water soluble benzopyran, stimulates insulin secretion (Hii and Howell, 1984). In addition, the biological activities of crude extracts of Pterocarpus species include hypoglycaemic and antidiabetic properties (Pterocarpus marsupium (Abesundara et al, 2004;Saxena and Vikram, 2004;Vats et al, 2004;Anandharajan et al, 2005;Dhanabal et al, 2006), Pterocarpus santalinus (Nagaraju et al, 1991;Kameswara Rao et al, 2001)) and also, cardiotonic activity (Pterocarpus marsupium (Mohire et al, 2007)), antimicrobial activity (Pterocarpus santalinus (Narayan et al, 2007); Pterocarpus angolensis (Steenkamp et al, 2004;Sami et al, 2009); Pterocarpus indicus (Ragasa et al, 2005)), antiulcerogenic activity (Pterocarpus santalinus (Narayan et al, 2007)). Methanolic extracts of Pterocarpus santalinus have also been reported to induce apoptosis of cancer HeLa cells (Kwon et al, 2006).…”

Photodynamic Inactivation for Phatogenic Bacteria: Adding Chlorophyll and Oxygen

“…One photosensitizer is chlorophyll which can be obtained from leaf extract [7]. Chlorophyll from Pterocarpus indicus was made as an antimicrobial drug [11]. This showed that adding chlorophyll was able to decrease colony, although it was not different with no treatment colony.…”