Antimutagenic and Anticancer Activity of Al Madinah Alhasawy Mint (Mentha longifolia) Leaves Extract

Al-Ali, Khalil; Abdelrazik, Mohamad; Alghaithy, Abdulaziz A.; Diab, Atef M.; El-Beshbishy, Hesham A.; Baghdadi, Hussam

doi:10.3923/pjbs.2014.1231.1236

Cited by 18 publications

(6 citation statements)

References 10 publications

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“…The M. longifolia extracts revealed an effectual antimutagenic action regarding NP, IQ [27] and NaN3 [30]. In another study, luteolin [31] and apigenin derivatives [28,29] were isolated from M. longifolia extracts show significant antimutagenic activity.…”

Section: Discussionmentioning

confidence: 99%

“…longifolia did not display mutagenic activity. In a study M. longifolia extract has shown the ability to counteract the 2-amino-3-methylimidazo-quinolidine (IQ) and nitrosopiperidine (NP) mutagenic effects [27]. Similarly, apigenin derivatives isolated M. longifolia ssp.…”

Section: Discussionmentioning

confidence: 99%

“…The antimutagenic activity of the M. longifolia was previously assayed by scrutinizing the organic extracts from the various parts of the plant [27,30]. The M. longifolia extracts revealed an effectual antimutagenic action regarding NP, IQ [27] and NaN3 [30].…”

Section: Discussionmentioning

confidence: 99%

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Mentha longifolia (L.) ssp. longifolia Essential Oil: Source of Natural Antioxidant and Antimutagen as Food Additive

Boran¹,

Uğur²

2017

SDÜ Fen Bil Enst Der

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Abstract:This research was performed to control the antioxidant activity, mutagenicity and antimutagenic effect of Mentha longifolia (L.) ssp. longifolia essential oil (EO), which is considered as a possible ingredient when producing healthy food. The antiradical activity was established using DPPH (2,2-diphenyl-1-picrylhydrazyl radical) and β-carotene/linoleic acid bleaching assays. The total phenolic content in the EO was evaluated by Folin Ciocalteau method (FCR). Ames Salmonella/microsome mutagenicity assay was applied to detect possible mutagenic and antimutagenic behavior. Our observations reveal that the IC50 value for DPPH radicals was 5.27 ± 0.13 mg/mL. The total antioxidant efficiency increased with an increase in the concentration of the EO, and IC50 value 11.7 ± 0.21 mg/mL. The total of phenolics was 186 ± 8.9 mg/g gallic acid equivalent/EO. Also, any concentrations of the EO used did not show mutagenic action but exhibited strong antimutagenic effects at 10.0-4.0 µg/plate concentrations. This research proposes that because of the antioxidant and antimutagenic characteristics, the EO is very advantageous and significant to the company's manufacturing food additives.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Mentha longifolia (L.) ssp. longifolia Essential Oil: Source of Natural Antioxidant and Antimutagen as Food Additive

Boran¹,

Uğur²

2017

SDÜ Fen Bil Enst Der

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“…Another cytotoxic study showed that methanolic extract of M. longifolia at a dose of 50 0 μg/ml resulted in 25% cell death and this cytotoxic effect was dose‐dependent, that is, further increasing the extract doses up to 1,000, 1,500, and 2,000 μg/mL produced 25, 50, and 62.5% deaths, respectively (Rahmat et al, ). In another recent study, Al‐Ali et al () reported that water and methanolic extracts of M. longifolia have significant antimutagenic and anticancer activities as depicted by different bioassays such as Brine shrimp bioassay, Ames mutagenicity bioassay. It reflects that Mentha species contain bioactive constituents having anticancer activity that can act as lead molecule for discovery of some new anticancer drugs with additional protective role against different pathogens.…”

Section: Biological Activities Of Genus Menthamentioning

confidence: 99%

Mentha: A genus rich in vital nutra‐pharmaceuticals—A review

Anwar

Abbas

Mehmood

et al. 2019

Phytotherapy Research

100

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The genus Mentha comprises several aromatic species, which are cultivated worldover due to their distinct aroma and commercial value. In addition to traditional food flavoring uses, Mentha are well recognized for their folk medicinal uses, especially to treat cold, fever, and digestive and cardiovascular disorders. A number of biological activities such as antioxidant, antimicrobial, biopesticidal, antitumor, anticancer, antiviral, antiallergic, antiinflammatory, antihypertensive, and urease inhibitory activity have been ascribed to Mentha. The traditional pharmacological attributes of Mentha herbs can be linked to the occurrence of bioactive phytochemicals such as terpenoids, alcohols, rosmarinic acid, and antioxidant phenolics among others. A rich source of bioactives, different species of Mentha, can be explored as a promising candidate for the development of nutra-pharmaceuticals. This review covers the nutritional, phytochemical, and traditional medicinal aspects and multiple biological activities of some commonly available species of Mentha so as to explore their potential applications for nutra-pharmaceutical and cosmo-nutraceutical industry. Detailed chemical profile and pharmaceutical attributes of various Mentha essential oils are also covered. Moreover, based on computational analysis, quantitative chemical component-antioxidant activity relationship model is reviewed to predict and correlate structure-activity relationship of potential bioactives in selected Mentha essential oils leading to discovery and developmenmt of novel natural drugs.

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“…Mentha longifolia L. (Madany or Habak), Mentha spicata L. (Balady), and Origanum majorana L. (Doosh) are traditionally used alone or mixed with tea and other herbs as refreshment drinks and in cuisine dishes for their aroma and flavor. Moreover, such mints are used 2 of 14 in folk medicine to treat nausea, bronchitis, anorexia, ulcerative colitis, liver diseases, and other symptoms [2]. The Lamiaceae family contains 236 genera, with M. longifolia and M. spicata belonging to the genus Mentha L. and O. majorana belonging to the genus Origanum L.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and Molecular Docking Study of Volatile Constituents from Different Aromatic Lamiaceous Plants Cultivated in Madinah Monawara, Saudi Arabia

Farouk¹,

Mohsen²,

Ali

et al. 2021

Molecules

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A comparative study of volatile constituents, antioxidant activity, and molecular docking was conducted between essential oils from Mentha longifolia L., Mentha spicata L., and Origanum majorana L., widely cultivated in Madinah. The investigation of volatile oils extracted by hydrodistillation was performed using Gas Chromatography-Mass Spectrometry (GC-MS). A total number of 29, 42, and 29 components were identified in M. longifolia, M. spicata, and O. majorana representing, respectively, 95.91, 94.62, and 98.42, of the total oils. Pulegone (38.42%), 1,8-cineole (15.60%), menthone (13.20%), and isopulegone (9.81%) were the dominant compounds in M. longifolia oil; carvone (35.14%), limonene (27.11%), germacrene D (4.73%), and β-caryophyllene (3.02%) were dominant in M. spicata oil; terpin-4-ol (42.47%), trans-sabinene hydrate (8.52%), γ-terpinene (7.90%), α-terpineol (7.38%), linalool (6.35%), α-terpinene (5.42%), and cis-sabinene hydrate (3.14%) were dominant in O. majorana oil. The antioxidant activity, assessed using DPPH free radical–scavenging and ABTS assays, was found to be the highest in O. majorana volatile oil, followed by M. spicata and M. longifolia, which is consistent with the differences in total phenolic content and volatile constituents identified in investigated oils. In the same context, molecular docking of the main identified volatiles on NADPH oxidase showed a higher binding affinity for cis-verbenyl acetate, followed by β-elemene and linalool, compared to the control (dextromethorphan). These results prove significant antioxidant abilities of the investigated oils, which may be considered for further analyses concerning the control of oxidative stress, as well as for their use as possible antioxidant agents in the pharmaceutical industry.

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Antimutagenic and Anticancer Activity of Al Madinah Alhasawy Mint (Mentha longifolia) Leaves Extract

Cited by 18 publications

References 10 publications

<i>Mentha longifolia</i> (L.) ssp. <i>longifolia</i> Essential Oil: Source of Natural Antioxidant and Antimutagen as Food Additive

<i>Mentha longifolia</i> (L.) ssp. <i>longifolia</i> Essential Oil: Source of Natural Antioxidant and Antimutagen as Food Additive

Mentha: A genus rich in vital nutra‐pharmaceuticals—A review

Antioxidant Activity and Molecular Docking Study of Volatile Constituents from Different Aromatic Lamiaceous Plants Cultivated in Madinah Monawara, Saudi Arabia

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