Antimutagenic effect of curcumin and its effect on the immune response in mice

Abstract

A wide array of antioxidative and anti-inflammatory substances derived from edible plants have been reported to possess chemopreventive and chemoprotective activities. Among the most extensively investigated and well-defined dietary chemopreventives is curcumin. Using the Ames test and in vivo micronucleus test, chemiluminescence test, blastic transformation test, and comet assay, we examined the antimutagenic effects of the chemically identified chemoprotective substance curcumin (diferuloylmethane) in the pure form on mutagenicity induced by three reference mutagens: aflatoxin B<sub>1</sub> (AFB<sub>1</sub>), 2-amino-3-metylimidazo[4,5-f]quinoline (IQ), and N-nitroso-N-metylurea (MNU), and the effect of curcumin on the immunosuppression caused by these mutagens. Curcumin in the pure form showed a clear antimutagenic and immunomodulatory activities on mutagenicity and immunosuppression induced by reference mutagens.  

Anti-Edematogenic and Anti-Granuloma Activity of a Synthetic Curcuminoid Analog, 5-(3,4-Dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one, in Mouse Models of Inflammation

“…According to Burgos-Morón et al [49], curcumin and its derivatives induces genotoxicity and high levels of toxicity in vitro and in human subjects, and cautioned its use in clinical practice and therapeutic interventions. In contrast, a significant body of research suggested that curcumin and/or its analog demonstrated significant antimutagenic activities [50,51,52,53,54] and inhibitory effect on genotoxicity induced by mutagens in cooked food [55]. However, the doses and concentrations of curcumin and its derivatives used in these studies vary.…”