Antimutagenic effect of Lentinula edodes (BERK.) Pegler mushroom and possible variation among lineages

Anticlastogenic activity exhibited by botryosphaeran, a new exopolysaccharide produced by Botryosphaeria rhodina MAMB-05

“…The work reported herein demonstrated no significant statistical differences in the experimental treatments assessing chromosome damage and anticlastogenic activities in relation to the body weight of the animals, thus concluding botryosphaeran did not serve as an energy source. These results were furthermore corroborated by the findings of other studies evaluating antimutagenic activity (e.g., mushroom of Lentinula edodes [48] incorporated into diets fed mice likewise did not influence body weight gains and reduced the frequency of MNPCEs induced by N-ethyl-N-nitrosourea), and antitumour activity (e.g., ␤-glucans extracted from the cell wall of C. albicans administered to mice infected with P815 mastocytoma cells resulted in suppression of tumour growth, and enhanced host-defense response to the tumour [35]). …”

Therapy of Myeloma In Vivo Using Marine Phospholipid in Combination with Agaricus blazei Murill as an Immune Respond Activator

“…A. blazei fed in dry powdered form to Wister rats at 10% of the diet exhibited significant chemopreventive influence on the promoting phase of the rat chemical hepatocarcinogenesis 36) . Similar antimutagenic effects were reported for diets containing powder of other mushroom Lentinula edodes 37,38) . It was observed that the NK cell activity was maintained at a more significant level in the gynecological cancer patient groups undergoing chemotherapy when A. blazei was orally consumed.…”

Genomic instability in blood cells is able to predict the oral cancer risk: an experimental study in rats

“…The bone marrow micronucleus test was performed according to Sugui et al (2003). One thousand polychromatic erythrocytes were analyzed per animal.…”