Antimutagenic Effect of Selenium and Vitamins Against the Genotoxicity Induced by Cobalt Chloride in Mice

Hassan, Neveen A.; Fahmy, Maha A.; Farghaly, Ayman A.; Hassan, Entesar E.

doi:10.1508/cytologia.71.213

Cited by 16 publications

(13 citation statements)

References 23 publications

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“…The effect of cobalt chloride in inducing chromosomal aberrations has been observed in mice in vivo (Palit et al, 1991), and its genotoxic activities have been tested in vivo in Drosophila melanogaster by Ogawa et al (1994) and in mice somatic and germ cells by Hassan et al (2006). In M. scutellaris, we found no changes in the number and morphology of the chromosomes after treatment with cobalt chloride, and the micronucleus assay showed that the applied concentration of cobalt chloride was not mutagenic in bees.…”

Section: Resultssupporting

confidence: 55%

Cobalt chloride induces metaphase when topically applied to larvae and pupae of the stingless bee Melipona scutellaris (Hymenoptera, Apidae, Meliponini)

Ueira-Vieira

Tavares²,

Morelli³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. In order to optimize preparations of bee metaphases, we tested cobalt chloride, which has been used as a metaphase inducer in other organisms, such as hamsters and fish. Four microliters of 65 mM cobalt chloride aqueous solution was topically applied to larval and pupal stages of the stingless bee Melipona scutellaris. The cerebral ganglion was removed after treatment and prepared for cytogenetic analysis. Identically manipulated untreated individuals were used as controls. The number of metaphases was increased 3-fold in treated individuals compared to controls. The micronucleus test showed no mutagenic effects of cobalt chloride on M. scutellaris cells. We concluded that cobalt chloride is a metaphase-inducing agent in M. ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (2): 2032-2037 (2013 Cobalt chloride induces metaphase in stingless bees 2033 scutellaris, thus being useful for cytogenetic analyses.

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Section: Resultssupporting

confidence: 55%

Cobalt chloride induces metaphase when topically applied to larvae and pupae of the stingless bee Melipona scutellaris (Hymenoptera, Apidae, Meliponini)

Ueira-Vieira

Tavares²,

Morelli³

et al. 2013

Genet. Mol. Res.

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“…For chromosomal preparations from mouse spermatocytes, the method of Hassan et al (2006) was followed.…”

Section: Cytological Preparations Chromosomal Aberrationmentioning

confidence: 99%

Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide

et al. 2020

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Background The genus Albizia (Leguminoseae) is used in folk medicine for the treatment of a wide range of ailments. Recently, saponins from plant origin have attracted much attention. Saponins are recorded to have a broad range of biological and pharmacological activities. This study was performed to evaluate the protective role of Albizia chinensis bark methanolic extract (MEAC) against the genotoxicity induced by cyclophosphamide (CP) using different mutagenic parameters. Results The results showed that MEAC induced an inhibitory effect against chromosomal aberrations of CP in mouse bone marrow and spermatocytes. Such effect was found to be significant (p < 0.01) with a dose of 100 mg/kg treated once for 24 h and also after repeated treatment at a dose of 25 mg/kg for 7 days. In sperm abnormalities, the protective effect of Albizia extract showed a dose-related relationship. Different doses of MEAC (25, 50, and 100 mg/kg) significantly (p < 0.01) ameliorated sperm abnormalities induced by CP dose-dependently. The percentage of sperm abnormalities was decreased to 5.14 ± 0.72 in the group of animals treated with CP plus MEAC (100 mg/kg) indicating an inhibitory effect of about 50%. Conclusion MEAC at the doses examined was non-genotoxic compared to control (negative) and exhibited a protective role against CP genotoxicity.

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“…High level of vitamin C in camel milk offered nucleophilic, anticlastogenic and antimutagenic role [60][61][62][63][64][65]. Selenium and zinc protect against the genotoxic effect of toxic compounds [66][67][68][69]. Casein and its product formed during pepsin hydrolysis protect mammalian cells against certain genotoxic compounds [70][71][72].…”

Section: Cytotoxic Effectmentioning

confidence: 99%

Therapeutic Applications of Camel’s Milk and Urine against Cancer: Current Development Efforts and Future Perspectives

Alebie¹,

Yohannes²,

Worku³

2017

J Cancer Sci Ther

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Antimutagenic Effect of Selenium and Vitamins Against the Genotoxicity Induced by Cobalt Chloride in Mice

Cited by 16 publications

References 23 publications

Cobalt chloride induces metaphase when topically applied to larvae and pupae of the stingless bee Melipona scutellaris (Hymenoptera, Apidae, Meliponini)

Cobalt chloride induces metaphase when topically applied to larvae and pupae of the stingless bee Melipona scutellaris (Hymenoptera, Apidae, Meliponini)

Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide

Therapeutic Applications of Camel’s Milk and Urine against Cancer: Current Development Efforts and Future Perspectives

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