Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract

Ham, Seung-Shi; Kim, Soohyun; Moon, Sun-Young; Chung, Mi Ja; Cui, Chengbi; Han, Eun-Kyung; Chung, Cha-Kwon; Choe, Myeon

doi:10.1016/j.mrgentox.2008.10.002

Cited by 68 publications

(40 citation statements)

References 16 publications

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“…To some extents, it is therefore, logical to say that there is a direct relationship between phenolic contents, antioxidant and antimutagenic activities. This is in line with the opinions of some investigators who previously used Ames test to evaluate mutagenicity and antimutagenicity of plant extracts and fruit juices (Zahin et al, 2010;Schneider et al, 1997;Cherdshewasart et al, 2008;Ham et al, 2009;Karekar et al, 2000;Oh et al, 2008;Rauscher et al, 1998;Son et al, 2003). In the other of FDFJ except M. fragrans, induction of negative percentage reduction of CP-induced CA or total arrest of cell division by the mixture of the FDFJ and CP at certain concentrations may be due to prooxidative activity of phenoilc compounds, causing generation of ROS to cause more DNA damages.…”

Section: Effects Of the Fdfj On A Cepa Chromosomessupporting

confidence: 85%

Mutagenic and antimutagenic potentials of fruit juices of five medicinal plants in Allium cepa L.: Possible influence of DPPH free radical scavengers

Akinboro¹,

Mohamed²,

Asmawi³

et al. 2011

Afr. J. Biotechnol.

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Mutagenic and antimutagenic activities of freeze dried fruit juices (FDFJ) ofTesting the mutagenic activity, onions were suspended in solution of different concentrations of FDFJ alone in tap water for 48 h. Thereafter, root tips were prepared and observed for dividing cells and chromosomal aberrations using a light microscope. Antimutagenicity screening was similar to the mutagenic evaluation, except that the solution of FDFJ was combined with 0.1% cylophosphamide-CP. Free radicals (2,2-diphenyl-1-picrylhyrazyl) scavenging activity of the FDFJ was tested using butylated hydroxylanisole (BHA) and butylated hydroxytoluene (BHT) as the standards and their phenolic contents were evaluated by comparing with gallic acid equivalents (GAE). The free radicals scavenging power of M. fragrans at 1 mg/ml was almost similar to that of BHA and BHT and its phenolic content was 21 ± 6.0 mg GAE/g, the highest among the tested juices. A. cepa cell division was inhibited in a dose-dependent manner by the FDFJ of M. fragrans, while the induced chromosomal aberrations were non dose dependent. The cytotoxicity and chromosomal aberrations of CP were suppressed throughout the tested concentrations of M. fragrans, unlike the effects of other four juices. These results suggest that the observed activities of FDFJ of M. fragrans may be due to the quantity and quality of phenolic compounds with antioxidant activity, suggesting its use in preventing the DNAdamaging effects of mutagens.

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Section: Effects Of the Fdfj On A Cepa Chromosomessupporting

confidence: 85%

Mutagenic and antimutagenic potentials of fruit juices of five medicinal plants in Allium cepa L.: Possible influence of DPPH free radical scavengers

Akinboro¹,

Mohamed²,

Asmawi³

et al. 2011

Afr. J. Biotechnol.

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“…In northwestern Russia, Siberia and Finland, the fruiting body of I. obliquus is decocted to treat cancer patients. At the year of 1955, the Medical Academy of Science in Moscow announced I. obliquus as anticancer substance, Ham et al, 2009;Lu et al, 2009 3β-Hydroxylanosta-8, 24-diene-21-al (4) Antimutagenic; (IC 50 , 232 mol ratio/32 pmol/TPA) antioxidant; hypoglycemic, Anticancer Ham et al, 2009;Lu et al, 2009;Chung et al, 2010 Lanosta-8, 23E-diene-3β, 22R, 25-triol (6) Antitumor promoting(IC 50 , 231 mol ratio/32 pmol/TPA) Taji et al, 2005 Lanosta-7, 9(11), 23E-triene-3β, 22R, 25-triol (8) Antitumor (Zhukovich et al, 2010).…”

Section: Tumor Inhibition Effects Of I Obliquusmentioning

confidence: 99%

Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus

Song¹,

Liu²,

Kong³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Of these, hispidin analogues are thought to be the bioactive constituents responsible for treating oxidativestress-induced human diseases, including cancer, hypertension, neurodegenerative diseases and autoimmune diseases (Zheng et al, 2009a). In nature, this fungus is restricted to cold habitats (45 u N-50 u N latitude) and is found growing primarily on the trunks of Betula trees, forming sclerotia, the medically active fungal structures, after 10 to 15 years growth (Ham et al, 2009). Its prominent bioactive metabolite synthesis has meant that demand for this fungus for pharmaceutical purposes has increased and sclerotia are no longer an adequate source of such compounds (Zheng et al, 2009a).…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide mediates the fungal-elicitor-enhanced biosynthesis of antioxidant polyphenols in submerged cultures of Inonotus obliquus

et al. 2009

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A fungal elicitor prepared from the cell debris of the plant-pathogenic ascomycete Alternaria alternata induces multiple responses by Inonotus obliquus cells, including an increase in generation of nitric oxide (NO), activity of phenylalanine ammonia lyase (PAL) and accumulation of total mycelial phenolic compounds (TMP), but does not trigger production of oxylipins or jasmonic acid (JA). The role of NO in TMP production was investigated via the effects of the NO-specific scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPITO) and the nitric oxide synthase (NOS) inhibitor aminoguanidine (AG). TMP profiles were assayed using 1 H NMR spectroscopy combining multivariate pattern recognition strategies. Pretreatment of I. obliquus mycelia with cPITO or AG suppressed not only elicitor-enhanced NO generation and PAL activity, but also the elicitor-induced increase in TMP production. This TMP reduction by either a NO scavenger or a NOS inhibitor was reversed by exogenous addition of either a NO donor, sodium nitroprusside, or JA separately. NMR-based metabonomic analysis of TMP profiles showed that the induced TMP were hispidin analogues including inoscavins, phelligridins, davallialactone and methyldavallialactone, which possess high antioxidant activities. Thus, NO mediates an elicitor-induced increase in production of antioxidant polyphenols in I. obliquus via a signalling pathway independent of oxylipins or JA, a mechanism which differs from those in some higher plants.

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Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract

Cited by 68 publications

References 16 publications

Mutagenic and antimutagenic potentials of fruit juices of five medicinal plants in Allium cepa L.: Possible influence of DPPH free radical scavengers

Mutagenic and antimutagenic potentials of fruit juices of five medicinal plants in Allium cepa L.: Possible influence of DPPH free radical scavengers

Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus

Nitric oxide mediates the fungal-elicitor-enhanced biosynthesis of antioxidant polyphenols in submerged cultures of Inonotus obliquus

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