Antimycobacterial activity and phytochemical properties of Eucalyptus camaldulensis (eucalyptus) extracted by deep eutectic solvents

Dheyab, Ali Sami; Ibrahim, Abdul Jabbar Khaleel; Aljumily, Ekremah Kheun; AlOmar, Mohamed Khalid; Bakar, Mohd Fadzelly Abu; Sabran, Siti Fatimah

doi:10.1016/j.matpr.2022.06.017

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Further, the altered geographical location of sources also affects the levels of UA. As the outer bark of eucalyptus trees present in the Temperate and the Mediterranean regions have higher concentrations of UA compared to the Eucalyptus trees present in the tropical and sub-tropical locations [ 24 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Ursolic acid: a natural modulator of signaling networks in different cancers

et al. 2022

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Incidence rate of cancer is estimated to increase by 40% in 2030. Furthermore, the development of resistance against currently available treatment strategies has contributed to the cancer-associated mortality. Scientists are now looking for the solutions that could help prevent the disease occurrence and could provide a pain-free treatment alternative for cancers. Therefore, efforts are now put to find a potent natural compound that could sever this purpose. Ursolic acid (UA), a triterpene acid, has potential to inhibit the tumor progression and induce sensitization to conventional treatment drugs has been documented. Though, UA is a hydrophobic compound therefore it is usually chemically modified to increase its bioavailability prior to administration. However, a thorough literature indicating its mechanism of action and limitations for its use at clinical level was not reviewed. Therefore, the current study was designed to highlight the potential mechanism of UA, its anti-cancer properties, and potential applications as therapeutic compound. This endeavour is a valuable contribution in understanding the hurdles preventing the translation of its potential at clinical level and provides foundations to design new studies that could help enhance its bioavailability and anti-cancer potential for various cancers.

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Section: Introductionmentioning

confidence: 99%

Ursolic acid: a natural modulator of signaling networks in different cancers

et al. 2022

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Chemical Composition, In Silico Investigations and Evaluation of Antifungal, Antibacterial, Insecticidal and Repellent Activities of Eucalyptus camaldulensis Dehn. Leaf Essential Oil from ALGERIA

Barboucha,

Rahim,

Boulebd

et al. 2024

Plants

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This study investigated the phytochemical profile and evaluated the antimicrobial and insecticidal properties of Eucalyptus camaldulensis Dehn. essential oil (EC-EO) from Algeria, using in vitro and in silico approaches. The yield of EC-EO was 0.27%, with gas chromatography-mass spectrometry (GC-MS) revealing spathulenol (58.24%), cryptone (17.22%), and o-cymene (15.53%) as the major compounds. EC-EO exhibited notable antibacterial activity, particularly against Salmonella typhimurium (14 ± 1.00 mm) and Staphylococcus aureus (14.5 ± 0.50 mm). It also showed effective antifungal activity against Penicillium sp. (11.5 ± 0.49 mm), Candida albicans (11.2 ± 0.29 mm), and Aspergillus fumigatus (9.8 ± 0.27 mm). Insecticidal assays against Tribolium castaneum were conducted using contact toxicity, fumigation toxicity, and repellent activity methods. The median lethal concentration (LC50) for contact toxicity was 0.011 μL/insect after 72 h, while the fumigation test had an LC50 of 122.29 μL/L air. Repellent activity tests showed percentage repellency (PR) values exceeding 80% after 6 h. The molecular geometry and electronic properties of the main compounds were studied using density functional theory (DFT) calculations. In addition, the interaction mode and binding affinity of these molecules with three key enzymes involved in antimicrobial activity, DNA gyrase, dihydrofolate reductase (DHFR) and Tyrosyl-tRNA synthetase (TyrRS), were explored by molecular docking.

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Antimycobacterial activity and phytochemical properties of Eucalyptus camaldulensis (eucalyptus) extracted by deep eutectic solvents

Cited by 2 publications

References 28 publications

Ursolic acid: a natural modulator of signaling networks in different cancers

Ursolic acid: a natural modulator of signaling networks in different cancers

Chemical Composition, In Silico Investigations and Evaluation of Antifungal, Antibacterial, Insecticidal and Repellent Activities of Eucalyptus camaldulensis Dehn. Leaf Essential Oil from ALGERIA

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