Antimycobacterial Activity and Safety Profile Assessment of <i>Alpinia galanga</i> and <i>Tinospora cordifolia</i>

Alajmi, Mohamed F.; Mothana, Ramzi A.; Al‐Rehaily, Adnan J.; Khaled, Jamal M.

doi:10.1155/2018/2934583

Cited by 14 publications

(11 citation statements)

References 40 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results agreed with Hemabarathy et al, (2009) observed that the hepatoprotective impact of the extract of A. galanga at 200 and 400 mg kg-1 treated paracetamol induced hepatotoxicity in rats. Alajmi et al, (2018) and Karunarathne et al, (2018) revealed that the oral administration of galangal extract did not produce any significant changes in ALT, AST levels indicating that there is no adverse impact of galangal on hepatocyte functions of rats. Sivakumar et al, (2010) and Sivakumar and Anuradha, (2011) showed that galangin can reduce kidney and liver injury.…”

Section: Discussionmentioning

confidence: 94%

Effect of (Alpinia officinarum) Hance on Sex Hormones and Certain Biochemical Parameters of Adult Male Experimental Rats

Negm

Ragheb

2019

Journal of Food and Dairy Sciences

View full text Add to dashboard Cite

Notwithstanding scientific advances, a significant number of the treatments in male infertility remained stayed vague. This study was aimed to study the impact of Alpinia Officinarum on sex hormones, serum antioxidant and biochemical markers in rats. Forty adult male rats, of (220 ± 10g) were partitioned into five groups (each consists of eight rats). The primary group was negative control group (-ve) and fed on basal diet only. The other four groups were subcutaneously injected with a single dose of lead acetate (200 mg/kg b.w) to reduce fertility, then were divided into 4 subgroups: including control positive group, and 2nd, 3rd and 4th subgroup were fed on basal diet with supplementation of dried A. officinarum at (5, 7.5 and 10%) respectively for two month. The results revealed that, supplementation with A. officinarum caused a significant positive effects on testes which due to a significant increase in the levels of serum total testosterones, Follicular stimulating Hormone (FSH), Luteinizing Hormone (LH) and Superoxide Dismutase (SOD) levels while Malondialdehyde (MDA) level was diminished. In addition, liver functions and serum lipid profiles were significantly improved compared to the positive control group. In conclusion: Our findings provide a scientific evidence to substantiate A. officinarum in improving fertility in human which may be due to its potent antioxidant properties and androgenic activities.

show abstract

Section: Discussionmentioning

confidence: 94%

Effect of (Alpinia officinarum) Hance on Sex Hormones and Certain Biochemical Parameters of Adult Male Experimental Rats

Negm

Ragheb

2019

Journal of Food and Dairy Sciences

View full text Add to dashboard Cite

show abstract

“…Alajmi et al . (2018) also showed that this compound is also helpful in the direct killing of M.tb bacteria.…”

Section: Ethnomedicinal Plants Of India and Their Key Bioactive Molecules On Tb Managementmentioning

confidence: 94%

“…(2018) for the first time reported that dichloromethane extract of T. cordifolia showed 32·3 and 22·7% inhibitory effect on sensitive and INH‐resistant M.tb strain, respectively, whereas ethanolic extract showed 23 and 18·3% anti‐mycobacterial effect on the same strains and same (50 μg ml −1 ) concentration (Alajmi et al . 2018). But they did not resolve any specific compound of Tinospora or the mechanism involved in this anti‐mycobacterial activity.…”

Section: Ethnomedicinal Plants Of India and Their Key Bioactive Molecules On Tb Managementmentioning

confidence: 99%

Potent anti‐mycobacterial and immunomodulatory activity of some bioactive molecules of Indian ethnomedicinal plants that have the potential to enter in TB management

et al. 2021

View full text Add to dashboard Cite

Tuberculosis (TB), is one of the deadliest infectious-diseases of human-civilization. Approximately one-third of global-population is latently-infected with the TB-pathogen Mycobacterium tuberculosis (M.tb). The discovery of anti-TB antibiotics leads to decline in death-rate of TB. However, the evolution of antibiotic-resistant, M.tb-strain, and the resurgence of different immune compromised diseases re-escalated the death-rate of TB. WHO has already cautioned about the chances of pandemic-situation in TB endemic countries unless the discovery of new antitubercular drugs, i.e., the need of the hour. Analysing the pathogenesis of TB it was found that M.tb evades the host by altering the balance of immune-response and affects either by killing the cells or by creating inflammation. In the preantibiotic era, traditional medicines were only therapeutic measures for different infectious-diseases including tuberculosis. The ancient-literatures of India or ample Indian traditional knowledge and ethnomedicinal-practices are evidence for the treatment of TB using different indigenous plants. However, in the light of modern scientific approach, anti-TB effects of those plants and their bioactive-molecules were not established thoroughly. In this review, focus has been given on five bioactive-molecules of different traditionally used Indian ethnomedicinal plants for treatment of TB or TB-like symptom. These compounds are also validated with proper identification and their mode of action with modern scientific approaches. The effectiveness of these molecules for sensitive or drug-resistant TB-pathogen in clinical or preclinical studies were also evaluated. Thus, our specific aim is to highlight such scientifically validated bioactive compounds having anti-mycobacterial and immuno-modulatory activity for future use as medicine or adjunct-therapeutic molecule for TB management.

show abstract

“…Commercially available Tinospora powder shows antimicrobial activity against Streptococcus mutans at 2% concentration [67]. Dichloromethane and ethanolic extracts of T. cordifolia have antimycobacterial activity against H37Rv INH-sensitive and resistant INH strains of Mycobacterium tuberculosis [68].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Therapeutic Potential of the Medicinal Plant Tinospora cordifolia–Minireview

Priya¹,

Balasubramanian²,

Shanmugaraj³

et al. 2022

Phyton

View full text Add to dashboard Cite

For thousands of years, plant based herbal medicines have been utilized by millions of people all over the world. Plant materials or products are used in different folk/traditional medical systems, such as the Chinese, African and Indian medical systems, like Siddha, Ayurveda, Unani, and Homeopathy. Tinospora cordifolia (TC) is a medicinal plant belonging to the family Menispermaceae. It is a big deciduous, climbing shrub growing prevalently in the tropical part of Indian subcontinent regions such as India, Pakistan, Nepal, Bhutan, Bangladesh and Srilanka, and in Myanmar, and China. Guduchi, Giloy, Shindilkodi, and Amritha are all the common names for this plant. Extracts from different parts of this herbal plant have been used to treat many diseases. In Ayurvedic medicine, extract from this plant is used for preparing "rasayanas", which is known to cure diabetes, skin diseases, allergic conditions, jaundice, cardiovascular diseases, rheumatoid arthritis, poisoning, and microbial infections. T. cordifolia has a many bioactive phytochemicals that have been isolated from its aerial parts and roots. Many bioactive principles have been reported from this plant which belong to various classes like alkaloids, aliphatic compounds, diterpenoid lactones, phenolics, flavonoids, glycosides, sesquiterpenoids, lignans, steroids and polysaccharides. T. cordifolia possesses medicinal properties such as antioxidant, antiallergic, antiinflammatory, antimicrobial, antiviral, antidote, antitumor, antileprotic, antispasmodic, and antidiabetic properties. The present review will provide a comprehensive therapeutic potential of T. cordifolia.

show abstract

Antimycobacterial Activity and Safety Profile Assessment of Alpinia galanga and Tinospora cordifolia

Cited by 14 publications

References 40 publications

Effect of (Alpinia officinarum) Hance on Sex Hormones and Certain Biochemical Parameters of Adult Male Experimental Rats

Effect of (Alpinia officinarum) Hance on Sex Hormones and Certain Biochemical Parameters of Adult Male Experimental Rats

Potent anti‐mycobacterial and immunomodulatory activity of some bioactive molecules of Indian ethnomedicinal plants that have the potential to enter in TB management

Therapeutic Potential of the Medicinal Plant Tinospora cordifolia–Minireview

Contact Info

Product

Resources

About