Antimycobacterial Activity of (<i>E</i>)-Phytol and Derivatives: A Preliminary Structure-Activity Study

Rajab, Mohamed S.; Cantrell, Charles L.; Franzblau, Scott G.; Fischer, Nikolaus H.

doi:10.1055/s-2006-957354

Cited by 126 publications

(65 citation statements)

References 1 publication

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“…Very similar patterns of activity of α-and β-ionones compared with the activity of E. arvense oil against P. aeruginosa, E. coli, S. aureus and C. albicans were observed previously and their activity correlated with their solubility in water, due to the great importance of the diffusion ability of the compounds in the disk diffusion assay (Griffin et al, 1999). trans-Phytol was the principal active component responsible for the antimycobacterial activity of the methanol extract of Leucas volkensii (Rajab et al, 1998).…”

Section: Resultssupporting

confidence: 73%

Composition and antimicrobial activity ofEquisetum arvense L. essential oil

2006

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The volatile constituents of the sterile stems of Equisetum arvense L. (Equisetaceae) were investigated for the first time using GC, GC/MS and (13)C-NMR. Twenty-five compounds were identified. Hexahydrofarnesyl acetone (18.34%), cis-geranyl acetone (13.74%), thymol (12.09%) and trans-phytol (10.06%) were the major constituents. A disk diffusion method was used for the evaluation of the antimicrobial activity of this oil against a panel of microorganisms (bacteria: Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteritidis; fungi: Aspergillus niger and Candida albicans). The 1:10 dilution of the essential oil of Equisetum arvense L. was shown to possess a broad spectrum of a very strong antimicrobial activity against all tested strains.

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Section: Resultssupporting

confidence: 73%

Composition and antimicrobial activity ofEquisetum arvense L. essential oil

2006

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“…Phytol, a diterpene found in F. thonningii has been shown to possess antibacterial effects. The mean inhibitory concentration of phytol (2 mg/ml) against Mycobacterium tuberculosis was comparable to that of ethambutol (0.95-3.8 mg/ml) (Rajab et al, 1998).…”

Section: Pharmacological Activity Antimicrobial Effectsmentioning

confidence: 75%

Phytochemistry, pharmacology and ethnomedicinal uses of Ficus thonningii (Blume moraceae): A review

Dangarembizi¹,

Erlwanger²,

Moyo³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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The common wild fig, Ficus thonningii, is extensively used in African ethnomedicine for treating a number of disease conditions which include diarrhoea, urinary tract infections, diabetes mellitus, gonorrhoea, respiratory infections, and mental illnesses. This review aims to present a logical analysis of the nutritional, phytochemical and pharmacological properties of F. thonningii in relation to its therapeutic applications. A bibliographic analysis of the uses, phytochemical constituents and phytophamacological properties of Ficus thonningii was carried out using published papers, medicinal plant databases and various ethnobotanical and ethnopharmacological books. Ficus thonningii contains various bioactive compounds which include alkaloids, terpenoids, flavonoids, tannins and active proteins, all of which contribute to its curative properties. In vitro and in vivo pharmacological studies revealed that F. thonningii possesses antimicrobial, antidiarrhoeal, antihelmintic, antioxidant, anti-inflammatory and analgesic properties. Acute and sub-chronic toxicity studies have shown that Ficus thonningii is non-toxic if administered orally in low doses. Scientific research has validated the ethnomedicinal claims that Ficus thonningii is useful in disease management. However, there is need to continue identifying, isolating and quantifying the active principles and possibly determine the mechanisms underlying its curative properties.

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“…Among the compounds identified by GC-MS (Table 2), phytol has been reported to have antimicrobial [26,27] and anti-inflammatory activities [28]. Shukla and Dwivedi [29] described the inhibitory effect of phenol against growth of Fusarium oxysporum.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Bamboo Leaf on the Growth of Pyricularia grisea Fungus

Toan

Xuan

et al. 2018

Agriculture

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Abstract:In this study, the effects of bamboo leaf were examined on mycelial growth of Pyricularia grisea, a fungus of rice blast disease that causes a great loss in rice production. The hexane extract exhibited maximal reduction on growth of P. grisea (IC 50 = 0.62 mg/mL), followed by aqueous and ethyl acetate extracts, while the methanol extract was least effective (IC 50 = 9.71 mg/mL). At 0.5-1.0 mg/mL doses, all extracting solvents showed inhibition on the growth of P. grisea, but at a 0.1 mg/mL concentration, the antifungal activity was solely observed on hexane and ethyl acetate extracts. By GC-MS (gas chromatography-mass spectrometry), 25 constituents were identified, principally belonging to long-chain fatty acids, sterols, phenols, phenolic acids, volatile oils, and derivatives of terpenes. It was suggested that compounds originated from hexane and ethyl acetate extracts such as fatty acids, oils, and phenols, and their derivatives were responsible for the antifungal activity of bamboo leaf. Non-polar constituents were accountable for the antifungal activity, although water-soluble compounds may play a role. Bamboo leaf appears to be a potent natural source to manage the infestation of P. grisea in rice cultivation.

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Antimycobacterial Activity of (E)-Phytol and Derivatives: A Preliminary Structure-Activity Study

Cited by 126 publications

References 1 publication

Composition and antimicrobial activity ofEquisetum arvense L. essential oil

Composition and antimicrobial activity ofEquisetum arvense L. essential oil

Phytochemistry, pharmacology and ethnomedicinal uses of Ficus thonningii (Blume moraceae): A review

Inhibitory Effects of Bamboo Leaf on the Growth of Pyricularia grisea Fungus

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