Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia mangostana

Suksamrarn, Sunit; Suwannapoch, Narisara; Phakhodee, Wong; Thanuhiranlert, Janthana; Ratananukul, Piniti; Chimnoi, Nitirat; Suksamrarn, Apichart

doi:10.1248/cpb.51.857

Cited by 215 publications

(137 citation statements)

References 20 publications

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“…In contrast, the same study reported only low inhibitory activity towards Escherichia coli, Klebsiella spp and Proteus spp. More recent studies have reported Mycobacterium tuberculosis 45 , S. aureus (including MRSA) 46 , Propionibacterium acnes and S. epidermidis 47 inhibitory activities of mangosteen xanthones. Numerous studies have also documented the anticancer effects of xanthones isolated from G. mangostana fruit pericarp.…”

Section: Discussionmentioning

confidence: 99%

An examination of the antimicrobial and anticancer properties of Garcinia cambogia fruit pericarp extracts

Hart

Cock

2016

BEMS Reports

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Background:Garcinia cambogia (synonym Garcinia gummi-gutta) is commonly known as brindleberry and Malabar tamarind. It has received considerable recent interest due to its potential in the prevention and treatment of obesity and obesity related diseases. The fruit pericarp also has traditional uses in the treatment of a wide variety of diseases and medical conditions, yet these have received relatively little investigation to date. Methods: Garcinia cambogia fruit extracts were investigated for their ability to inhibit the growth of a panel of bacteria of medicinal importance. The extracts were also tested for their ability to block the proliferation of the CaCo 2 and HeLa human carcinoma cell lines. Results: Garcinia cambogia methanolic, aqueous and ethyl acetate extracts displayed broad spectrum antimicrobial activity, inhibiting the growth of between 16 (64 %; ethyl acetate extract) and 22 (88 % aqueous extract) of the 25 bacterial species tested. Strong inhibitory activity was detected with minimum inhibitory concentration (MIC) values <1000 µg/ml against many bacteria. All extracts were effective against both Gram negative and Gram positive bacteria, although Gram negative bacteria were more sensitive. All extracts displayed anti-proliferative activity against CaCo 2 and HeLa carcinoma cells, yet were non-toxic in the Artemia franciscana bioassay, with LC50 values greatly in excess of 1000 µg/ml. Conclusion: The inhibitory bioactivity against a range of microbes, the anti-proliferative activity against CaCo 2 and HeLa cells, as well as the lack of toxicity, indicate the potential for G. cambogia in the discovery and development of new natural pharmaceuticals.

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Section: Discussionmentioning

confidence: 99%

An examination of the antimicrobial and anticancer properties of Garcinia cambogia fruit pericarp extracts

Hart

Cock

2016

BEMS Reports

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“…This family is known to be a rich source of polycyclic polyprenylated acylphloroglucinols (PPAPs) with a large spectrum of biological activities (Cuesta-Rubio et al, 2005;Marti et al, 2009). Besides, some plants of Clusiaceae family have their pharmacological properties associated with the presence of xanthone derivatives, which has antioxidant and anticarcinogenic activities (Sundaram et al, 1983;Chen et al, 1996;Iinuma et al, 1996;Suksamrarn et al, 2003;Ee et al, 2008;Chomnawang et al, 2009;Hung et al, 2009).…”

Section: Platonia Insignismentioning

confidence: 99%

“…Among the Clusiaceae family, Platonia insignis Mart., commonly known as "bacuri," is a timber and fruit native species of the Brazilian Amazon (Sundaram et al, 1983;Chen et al, 1996;Iinuma et al, 1996;Suksamrarn et al, 2003;Ee et al, 2008;Chomnawang et al, 2009;Hung et al, 2009). The bacuri fruit has a thick-skin, and is 7-15 cm long and 5-15 cm in diameter, weighing 200-1000 g, containing a large quantity of resins.…”

Section: Platonia Insignismentioning

confidence: 99%

Superoxide dismutase and catalase activities in rat hippocampus pretreated with garcinielliptone FC fromPlatonia insignis

Júnior

Almeida

Costa

et al. 2011

Pharmaceutical Biology

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“…It is one of the most popular fruits named 'the queen of fruits'. It has been known to be of good medicinal value and is traditionally used in folk medicines for treatment of abdominal pain, diarrhea, dysentery, infected wounds, suppuration, chronic ulcer, leucorrhoea and gonorrhoea 4 . Phytochemical studies showed that hulls of this plant contained various secondary metabolites, such as tannins, triterpenes, anthocyanins, xanthones, polysaccharides, phenolic compounds, vitamins B1, B2 and C, and other bioactive substances 5 .…”

Section: Garcinia Mangostana Linn (Mangosteen) Familymentioning

confidence: 99%

Untitled

Kosem¹,

Han²,

Moongkarndi³

2007

ScienceAsia

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Garcinia mangostana has been documented in Thai traditional medicine in various aspects. Although many benefits have been claimed, few scientific reports are available in the literature. In the present study, the methanolic extract from G. mangostana hulls (GME) was assessed for antioxidant and cytoprotective activities. The results showed that GME contained phenolic compounds and possessed reducing power as well as Fe 2+ chelating activity. The antioxidant properties were determined by scavenging DPPH, nitric oxide and lipid radicals in dose-dependent manners. In particular, the powerful scavenging activities were found against hydroxyl and superoxide radicals when investigated using ESR spectrometry. GME also enhanced the cell survival by decreasing the oxidative damage in ECV304 endothelial cells after H 2 O 2 exposure. These data indicated that GME played a pivotal role on the antioxidant and chemopreventive activities via a reducing mechanism and inhibition of intracellular oxidative stress, respectively.

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Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia mangostana

Cited by 215 publications

References 20 publications

An examination of the antimicrobial and anticancer properties of Garcinia cambogia fruit pericarp extracts

An examination of the antimicrobial and anticancer properties of Garcinia cambogia fruit pericarp extracts

Superoxide dismutase and catalase activities in rat hippocampus pretreated with garcinielliptone FC fromPlatonia insignis

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