Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites

Saifullah, Bullo; Zowalaty, Mohamed E. El; Arulselvan, Palanisamy; Fakurazi, Sharida; Webster, Thomas J.; Geilich, Benjamin M.; Hussein, Mohd Zobir

doi:10.2147/dddt.s63753

Cited by 9 publications

(4 citation statements)

References 30 publications

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“…However, in basic conditions, formation precipitation of metal ions as their respective hydroxide can influence the adsorption results, therefore we have selected the maximum adsorption under acidic environment e.g. <pH 7 24–26 . Lead ions showed the highest adsorption of about 95.20% at pH 4 and the remaining three metal ions Cr 6+ , Cd 2+ and Zn 2+ , pH 6 was found to be the optimum with maximum adsorption of 90.20%, 75.50% and 67.30%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Palm Kernel Shell as an effective adsorbent for the treatment of heavy metal contaminated water

Baby

Saifullah

Hussein

2019

Sci Rep

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100

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Heavy metal contamination in water causes severe adverse effects on human health. Millions of tons of kernel shell are produced as waste from oil palm plantation every year. In this study, palm oil kernel shell (PKS), an agricultural waste is utilized as effective adsorbent for the removal of heavy metals, namely; Cr6+, Pb2+, Cd2+ and Zn2+ from water. Different parameters of adsorptions; solution pH, adsorbent dosage, metal ions concentration and contact time were optimized. The PKS was found to be effective in the adsorption of heavy metal ions Cr6+, Pb2+, Cd2+ and Zn2+ from water with percentage removal of 98.92%, 99.01%, 84.23% and 83.45%, respectively. The adsorption capacities for Cr6+, Pb2+, Cd2+ and Zn2+ were found to be 49.65 mg/g, 43.12 mg/g, 49.62 mg/g and 41.72 mg/g respectively. Kinetics of adsorption process were determined for each metal ion using different kinetic models like the pseudo-first order, pseudo-second order and parabolic diffusion models. For each metal ion the pseudo-second order model fitted well with correlation coefficient, R2 = 0.999. Different isotherm models, namely Freundlich and Langmuir were applied for the determination of adsorption interaction between metal ions and PKS. Adsorption capacity was also determined for each of the metal ions. PKS was found to be very effective adsorbent for the treatment of heavy metal contaminated water and short time of two hours is required for maximum adsorption. This is a comprehensive study almost all the parameters of adsorptions were studied in detail. This is a cost effective and greener approach to utilize the agricultural waste without any chemical treatment, making it user friendly adsorbent.

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Section: Resultsmentioning

confidence: 99%

Palm Kernel Shell as an effective adsorbent for the treatment of heavy metal contaminated water

Baby

Saifullah

Hussein

2019

Sci Rep

Self Cite

100

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“…However, the antibacterial property of HA is less obvious, and it could affect the remineralization process since the acidic environment causing the demineralization is produced by specific types of bacteria. It has been reported that zinc inhibits dental plaque formation in vivo due to its antibacterial effect [6]. Considering plaque removal can prevent enamel demineralization, we assume that hydroxyapatite with zinc ions would weaken the demineralization of enamel.…”

Section: Introductionmentioning

confidence: 98%

Zinc-Containing Hydroxyapatite Enhances Cold-Light-Activated Tooth Bleaching Treatment In Vitro

Shi²,

Li³

2017

BioMed Research International

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Cold-light bleaching treatment has grown to be a popular tooth whitening procedure in recent years, but its side effect of dental enamel demineralization is a widespread problem. The aim of this study was to synthesize zinc-substituted hydroxyapatite as an effective biomaterial to inhibit demineralization or increase remineralization. We synthesized zinc-substituted hydroxyapatite containing different zinc concentrations and analysed the product using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and energy dispersive spectrometer (EDS). The biological assessment of Zn-HA was conducted by CCK-8 assay and bacterial inhibition tests. pH cycling was performed to estimate the effect of Zn-HA on the enamel surface after cold-light bleaching treatment. The XRD, FTIR, and EDS results illustrated that zinc ions and hydroxyapatite combined in two forms: (1) Zn2+ absorbed on the surface of HA crystal and (2) Zn2+ incorporated into the lattice of HA. The results indicated that 2% Zn-HA, 4% Zn-HA, and 8% Zn-HA effectively inhibited the growth of bacteria yet showed poor biocompatibility, whereas 1% Zn-HA positively affected osteoblast proliferation. The XRD and scanning electron microscopy (SEM) results showed that the use of Zn-HA in pH cycling is obviously beneficial for enamel remineralization. Zinc-substituted hydroxyapatite could be a promising biomaterial for use in cold-light bleaching to prevent enamel demineralization.

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“…Hybridizing oleanolic acid with 4-aminosalicylic acid resulted in compound 4 with enhanced antibacterial activity against certain strains of bacteria. 4-Aminosalicylic acid has been reported to inhibit E. coli growth (Saifullah et al 2014).…”

Section: Resultsmentioning

confidence: 99%

Design of Oleanolic Acid-based Hybrid Compounds as Potential Pharmaceutical Scaffolds

Khwaza

Oyedeji

Aderibigbe

et al. 2022

LDDD

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Background: Infectious diseases as well as cancer are the leading causes of death worldwide. Drug resistance usually results in their treatment requiring a combination of two or more drugs. Objective: Oleanolic-based hybrid compounds were prepared via esterification and characterized using FTIR, NMR, and LC-MS. In vitro antibacterial and in vitro cytotoxicity studies were performed. Method: Oleanolic acid was hybridized with selected known pharmaceutical scaffolds via the carboxylic acid functionality to develop therapeutics with increased biological activity. Antibacterial activity was determined using the micro-dilution assay against selected Gram-positive and Gram-negative bacteria and cytotoxicity using the sulforhodamine B assay. Results: Compound 8 displayed potent antibacterial effect against five strains of bacteria such as Bacillus subtilis, Staphylococcus aureus, Proteus vulgaris, Klebsiella oxytoca, and Escherichia coli with MIC values of 1.25, 0.078, 0.078, 1.25, 1.25 mg/mL when compared to the control, oleanolic acid (MIC = 2.5 mg/mL). Furthermore, in vitro cytotoxicity, as determined using the SRB assay, against selected cancer cells revealed that compound 7 was the most cytotoxic to MDA, DU145, and MCF-7 cell lines with IC50 values of 69.87±1.04, 73.2±1.08, and 85.27±1.02 µg/mL, respectively, than oleanolic acid with an IC50 ˃200 µg/mL. Conclusion: Hybridization of oleanolic acids was successful, and further development of these potential antibacterial compounds with reduced cytotoxicity is warranted.

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Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites

Cited by 9 publications

References 30 publications

Palm Kernel Shell as an effective adsorbent for the treatment of heavy metal contaminated water

Palm Kernel Shell as an effective adsorbent for the treatment of heavy metal contaminated water

Zinc-Containing Hydroxyapatite Enhances Cold-Light-Activated Tooth Bleaching Treatment In Vitro

Design of Oleanolic Acid-based Hybrid Compounds as Potential Pharmaceutical Scaffolds

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