Antimyocardial antibodies in patients with coronary heart disease

Bauer, Heinz; Waters, Theresa; Talano, James V.

doi:10.1016/0002-8703(72)90400-0

Cited by 19 publications

(4 citation statements)

References 14 publications

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“…This may depend upon certain factors which may potentiate cardiotoxic effects of antibodies: two of these have been reported in experimental studies, isoprenaline (Chaturvedi and Mehrotra, 1969), and Coxsackie B4 infection (Chaturvedi et al, 1971a), but it is not known how far these experimental observations can be extrapolated to human patients. Bauer et al (1972) found no difference in anticardiac antibody titres in complicated compared with uncomplicated cases of myocardial infarction. There was no relation between antibody titre and the occurrence of the post-cardiotomy syndrome (to be published).…”

Section: Discussionmentioning

confidence: 64%

Leucocyte migration inhibition test in cases of ischaemic heart disease.

Sharma¹,

Ahuja²,

Op³

et al. 1978

Heart

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SUMMARY Cases of ischaemic heart disease have been studied for the cell-mediated immune response against human heart antigen by using the leucocyte migration inhibition test. In 30 cases of acute myocardial infarction, the leucocyte migration inhibition values started increasing from the first week reaching a peak in 3 to 4 weeks and then declining but still above control values 12 months after infarction. The leucocyte migration inhibition values were significantly higher than control values in another 10 patients with late complications of previous infarction and in those patients with acute myocardial infarction who were less than 40 years of age, who had extensive anterior infarction, or who had a past history ofangina pectoris. The leucocyte migration inhibition values were negligible in all the 12 patients with stable angina pectoris, but were high in 2 of the 8 with unstable angina and in 3 of the 4 with the intermediate coronary syndrome. The leucocyte migration inhibition values were much higher inpatients with complications, which may be the result of cardiac damage by a cell-mediated immune response.

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Section: Discussionmentioning

confidence: 64%

Leucocyte migration inhibition test in cases of ischaemic heart disease.

Sharma¹,

Ahuja²,

Op³

et al. 1978

Heart

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“…Bauer et al [1] reported the presence of anticardiac anti body in 45% of patients with acute my ocardial infarction with complications in comparison with 36% of patients with un complicated myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

T Lymphocytes and Anticardiac Antibodies in Patients with Ischemic Heart Diseases

Agrawal¹,

Gupta²,

Chaturvedi³

et al. 1978

Int Arch Allergy Immunol

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85 patients with a variety of ischemic heart diseases were examined for the proportion of T cells and the presence of anticardiac antibodies. Patients with acute myocardial infarction during the 2nd and 3rd week of initial acute episode had a higher proportion of T lymphocytes and a higher proportion of patients developed anticardiac antibody. Similar was the case with patients with angina. The extent of infarction and accompanying complications did not change the immune parameters studied. The relationship of anticardiac antibodies and T lymphocytes in context of ischemic heart diseases is discussed.

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“…2 Their presence in ischaemic heart disease3 4 and in the post-cardiotomy state5 presumably merely reflects cardiac damage, while their presence in other disorders6 7 suggests they may be a non-specific finding.…”

mentioning

confidence: 99%

Heart antibodies in cardiomyopathies.

Trueman¹,

Thompson²,

Cummins³

et al. 1981

Heart

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SUMMARY The reported frequency of circulating heart reactive antibodies in cardiomyopathies has varied and their significance is unknown. In this study such antibodies were sought in patients with primary congestive and hypertrophic cardiomyopathies and other heart diseases.Standard "single sandwich" and the more sensitive "double sandwich" indirect immunofluorescence techniques failed to disclose a significant difference between any cardiomyopathic group and controls in repeated experiments.With both techniques results were subject to considerable method-specific artefacts and observer variation. No published work associating heart antibodies detected by immunofluorescence methods with cardiomyopathies adequately takes these into account.

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Antimyocardial antibodies in patients with coronary heart disease

Cited by 19 publications

References 14 publications

Leucocyte migration inhibition test in cases of ischaemic heart disease.

Leucocyte migration inhibition test in cases of ischaemic heart disease.

T Lymphocytes and Anticardiac Antibodies in Patients with Ischemic Heart Diseases

Heart antibodies in cardiomyopathies.

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