Antineoplastic Agents. 551. Isolation and Structures of Bauhiniastatins 1−4 from Bauhinia purpurea

Pettit, George R.; Numata, Atsushi; Iwamoto, Chika; Usami, Yoshihide; Yamada, Takeshi; Ohishi, Hirofumi; Cragg, Gordon M.

doi:10.1021/np058075+

Cited by 105 publications

(79 citation statements)

References 7 publications

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“…This is in agreement with Tomoko Akase et al (2011) [18] who suggested that kaempferol, an active polymethoxyflavone found in Kaempferia parviflora reduced the accumulation of visceral fat in diet induced obese rats by escalating lipid metabolism through down regulation of SREBPs [19]. The antioxidant and anti hyperlipidemic activity of bauhiniastatins falls in line with the work of Pettit et al (2005) [20] who reported the antioxidant, anti inflammatory and antineoplastic activity of bauniniastatins 1-4 in P388 lymphocytic leukemia cell line. It is well known that insulin can indirectly inspire leptin secretion through its collective effects on the metabolism of nutrients, especially on glucose utilization in adipocytes.…”

Section: Discussionsupporting

confidence: 86%

Antiobesity Activity of Bauhinia purpurea Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Padmaja¹,

Naidu²,

Kumar³

et al. 2014

ABB

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Obesity is well recognized as a global public health concern and the quest continues to explore natural product-based novel therapeutics. Bauhinia purpurea finds its place in traditional medicine as an effective anti-ulcer, antiplatelet, wound healing and hypolipidemic agent. The present study investigated the effects of ethanolic extract of Bauhinia purpurea (EEB) on the changes in body weight, lean mass, fat free mass, fat percent, tissue and plasma lipid profiles, plasma glucose, insulin and insulin resistance as well as on the activity of amylase, lipase, leptin and adiponectin levels in high caloric diet (HCD) induced obese rats. After induction of obesity with HCD, rats were administered orally with EEB (100, 200 and 300 mg•kg −1 BW) or orlistat (5 mg•kg −1 BW) once daily for 42 days. HCD substantially increased the body weight, fat free mass, fat percent, glucose, insulin resistance, tissue and plasma lipid profiles (Except HDL), leptin and the activities of amylase and lipase. EEB at a dose of 300 mg•kg −1 BW exerted its therapeutic effects similar to orlistat in decreasing body weight, insulin resistance, levels of glucose, leptin, plasma and tissue lipids, lipase and amylase but increasing HDL and adiponectin in HCD fed obese rats, which could be due to bioactive factors present in EEB, as revealed by LC-MS analysis. These findings suggest that EEB administration suppresses high-caloric-diet-induced obesity and it can be developed as a potential candidate for the treatment of obesity and associated complications.

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Section: Discussionsupporting

confidence: 86%

Antiobesity Activity of Bauhinia purpurea Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Padmaja¹,

Naidu²,

Kumar³

et al. 2014

ABB

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“…The final structural model obtained for pancratistatin is shown in Figure 1. Crystal data and experimental details follow: C 14 H 15 NO 8 , mol wt = 324.27, crystal size 0.32 × 0.13 × 0.03 mm, orthorhombic, space group P2 1 …”

Section: Crystal Structure Of Pancratistatin (1)mentioning

confidence: 99%

Antineoplastic Agents. 553. The Texas Grasshopper Brachystola magna

et al. 2005

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Bioassay (P388 lymphocytic leukemia cell line and human cancer cell lines) -guided separation of an extract prepared from the previously chemically uninvestigated Texas grasshopper Brachystola magna led to isolation of the cancer cell growth inhibitory pancratistatin (1), narciclasine (2) and ungeremine (3). Pancratistatin (1) was first isolated from the bulbs of Hymenocallis littoralis (a.k.a. Pancratium littorale Jacq) and the original crystal structure was deduced by X-ray analysis of a monomethyl ether derivative. In the present study a crystal of pancratistatin (1) was isolated from an extract of B. magna, which led to the X-ray crystal structure of this anticancer drug. Since isoquinoline derivatives 1-3 are previously known only as constituents of amaryllidaceous plants, some of the interesting implications of their rediscovery in the grasshopper B. magna that does not appear to utilize amaryllis family plants were discussed.In 1965-66 we began the first exploratory survey of terrestrial arthropods as potential sources of new and structurally unique anticancer drugs and by 1968 had uncovered a number of promising leads. 2 Over the relatively short four year period when resources were available, we isolated, e.g. antineoplastic constituents from butterfly wings, 3a an Asian beetle, 3b and a wasp. 3c Recently, this relatively unexplored area 4 for discovering medically useful new drugs has begun to be revisited on a much larger scale. 5 One of the insect leads we began to pursue in 1967 was the lubber grasshopper 6 Brachystola magna collected in Texas, but this foraging generalist ranger moved north to Minnesota and west to Arizona. 7 Most grasshoppers are usually polyphagous and pursue plants from a broad variety of taxa. However, B magna will even consume other insects including grasshoppers alive or dead. 7,8 In this regard, it's believed that insects vary their diet to obtain, e.g. plant constituents important for their own chemical defense. 7 When 2-propanol extracts of B. magna were found to provide a 40% increase in life span (at 200 mg/Kg) against the U.S. National Cancer Institute murine P388 lymphocytic leukemia, we gave increased attention to the lead. By 1970 a combination of negative events occurred, of which the most serious was the untimely passing of our entomologist colleague, D. G. Ford. This coincided with, for practical purposes, the disappearance of B. Magna from the southwest along with the necessary financial resources. Because the extract from the initial collection (less than 1 kg) of B. magna amounted to only 11 g, isolation of the antineoplastic constituent had to await the development of improved bioassays (especially with cancer cell lines), isolation and instrumental techniques. The rather surprising solution to this research objective now follows:The original Texas collection of Brachystola magna provided a 2-propanol extract that upon solvent partitioning between 9:1→1:1 CH 3 OH-H 2 O and hexane→CH 2 CL 2 and the H 2 O * To whom correspondence should be addressed. Te...

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“…For instance, Bauhinia purpurea has shown antidiabetic, analgesic, anti-inflammatory, antipyretic, antimalarial, antifungal, cytotoxic and thyroid hormone-stimulating activities as well as free radical scavenging [6][7][8][9][10][11][12][13][14] . Phytochemical studies with Bauhinia purpurea had related the presence of several molecules which could be potential corrosion inhibitors, such as flavonoids (rutin 7 , isoquercetrin 7 , 5,6-dihydroxy-7-methoxyflavone 6-O-β-D-xylopyranoside 15 , kaempferol 16 , quercetin 16 , isohammetin 16 , strobopinin 6 , demothoxymatteucinol 6 , bauhinoxepin C-J 6 and bauhinistatins1-4 1 ) in addition to phytosterols and fatty acids 17 .…”

Section: Introductionmentioning

confidence: 99%

The inhibitory action of Bauhinia purpurea extracts on the corrosion of carbon steel in sulfuric acid medium

et al. 2016

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The inhibitory effect of Bauhinia purpurea (Fabaceae) extract was studied in the corrosion of carbon steel in 1.0 mol•L -1 sulfuric acid solution. This plant was collected from the Brazilian rainforest. The carbon steel protection was observed by varying the extract concentration from 50 to 500 mg•L -1 . Polarization curves revealed that this extract acted as an adsorption inhibitor decreasing both anodic and cathodic density currents. Weight loss measurements showed that the extract remains stable for at least 72 hours. The adsorption process of this extract obeyed the Langmuir adsorption isotherm. Lastly, Arrhenius plot suggested the physical adsorption of the extract.

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Antineoplastic Agents. 551. Isolation and Structures of Bauhiniastatins 1−4 from Bauhinia purpurea

Cited by 105 publications

References 7 publications

Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Antineoplastic Agents. 553. The Texas Grasshopper Brachystola magna

The inhibitory action of Bauhinia purpurea extracts on the corrosion of carbon steel in sulfuric acid medium

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Antineoplastic Agents. 551. Isolation and Structures of Bauhiniastatins 1−4 from Bauhinia purpurea

Cited by 105 publications

References 7 publications

Antiobesity Activity of &lt;i&gt;Bauhinia purpurea&lt;/i&gt; Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Antiobesity Activity of &lt;i&gt;Bauhinia purpurea&lt;/i&gt; Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Antineoplastic Agents. 553. The Texas Grasshopper Brachystola magna

The inhibitory action of Bauhinia purpurea extracts on the corrosion of carbon steel in sulfuric acid medium

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Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats