Antineoplastic Effects of N6-(△2-Isopentenyl)adenosine against L-1210 Mouse Lymphocytic Leukemic Cells Using a Polymeric Delivery System

Antiproliferative Activity of N6-Isopentenyladenosine on HCT-15 Colon Carcinoma Cell Line

“…Recently, we demonstrated that iPA inhibits the growth of MCF-7 breast cancer cells in a dosedependent manner with interference on cell cycle, which showed that iPA-induced growth arrest could be associated to apoptosis . iPA has been reported to induce differentiation of human leukemia cells (Ishii et al, 2002), to inhibit proliferation of a Kras-transformed rat thyroid cell line (Laezza et al, 2006) and to exert anti-leukemic activity against a mouse leukemia cell line (Chang and Hacker, 1982). Laezza et al (1997) demonstrated that iPA influenced cAMPdependent organization of the microfilaments in a thyroid cell line (FRTL-5 cells) by decreasing cAMP levels, subsequently by inhibiting DNA synthesis.…”

N6‐isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation

“…Moreover, it is known that i 6 A and its analogs show anti-neoplastic activity in vitro, where it can inhibit cell proliferation of several mammalian cell lines. i 6 A induces apoptosis in tumor cells, including myeloid and lymphoblastic cells lines (5)(6)(7)(8)(9)(10)(11)(12)(13).…”

N6‐isopentenyladenosine: A potential therapeutic agent for a variety of epithelial cancers

“…i 6 A has been reported to induce differentiation of human leukemia cells 10 to inhibit proliferation of a Kras-transformed rat thyroid cell line 11 and to exert anti-leukemic activity against a mouse leukemia cell line. 12 Together, the available evidence suggests that the biochemical activity of the human IPT protein encoded by the TRIT1 gene and its possible byproduct i 6 A can inhibit tumor growth. Here, we describe our analysis of the effect of i 6 A on the growth of several human epithelial cancer cell lines and of the mechanisms by which it exerts its effects.…”