Antineoplastic potential of curcumin (cooperative study in Bulgaria and Germany)

Ilieva, Yana; Kaloyanov, Kaloyan; Yosifov, Deyan Yordanov; Robev, Bozhil; Zhelezova, Ivelina; Genova, Michelle; Mihova, Antoaneta; Balatzenko, Gueorgui; Zaharieva, Maya M.; Berger, Martin R.; Konstantinov, Spiro

doi:10.1007/s11101-014-9351-7

Cited by 7 publications

(7 citation statements)

References 79 publications

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“…These findings are in line with previous investigations of the drug in HL-60/Dox, and could be ascribed to active unilateral efflux of the drug via the xenobiotic efflux pump overexpressed in this cell line (Alaikov et al, 2007;Ilieva et al, 2014).…”

Section: Discussionsupporting

confidence: 92%

“…While in the parent HL-60 there was recruitment of caspase-9 especially after exposure to free curcumin or the pH-sensitive system, only the latter induced some disappearance of the procaspase-8 band. These data are indicative for activation of the mitochondrial, intrinsic-apoptotic signaling pathway, in unison with preceding reports (Kuo et al, 2011;Liao et al, 2008), albeit the recruitment of the extrinsic pathway by the pH-sensitive system is in line with published data for free curcumin as well (Bush et al, 2001;Ilieva et al, 2014).…”

Section: Discussionsupporting

confidence: 92%

“…Curcumin has been also documented to exert chemopreventive and drug-resistance modulating activities (Ilieva et al, 2014;Shehzad et al, 2010;Singh and Khar, 2006).…”

mentioning

confidence: 99%

“…Curcumin is characterized by an exceptionally low aqueous solubility (11 ng/ml), and by marked chemical instability (t 1/2 in buffer solution at pH 7.4 at 37°C is less than 10 min) (Priyadarsini, 2009;Wang et al, 1997;Zhongfa et al, 2012). It is well appreciated that the cytotoxic and apoptogenic properties of curcumin are concentrationdependent and require continuous exposure of cancer cells to 5-50 μ M of curcumin (Ilieva et al, 2014;Sou, 2012). Unfortunately, even applied at extensive oral doses of several grams daily, curcumin has a very low bioavailability.…”

mentioning

confidence: 99%

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Curcumin loaded pH-sensitive hybrid lipid/block copolymer nanosized drug delivery systems

Jelezova

Drakalska

Momekova

et al. 2015

European Journal of Pharmaceutical Sciences

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Curcumin is a perspective drug candidate with pleiotropic antineoplastic activity, whose exceptionally low aqueous solubility and poor pharmacokinetic properties have hampered its development beyond the preclinical level. A possible approach to overcome these limitations is the encapsulation of curcumin into nano-carriers, incl. liposomes. The present contribution is focused on feasibility of using hybrid pH-sensitive liposomes, whereby curcumin is entrapped as a free drug and as a water soluble inclusion complex with PEGylated tertbutylcalix[4]arene, which allows the drug to occupy both the phospholipid membranes and the aqueous core of liposomes. The inclusion complexes were encapsulated in dipalmithoylphosphathydilcholine:cholesterol liposomes, whose membranes were grafted with a poly(isoprene-b-acrylic acid) diblock copolymer to confer pH-sensitivity. The liposomes were characterized by DLS, ζ-potential measurements, cryo-TEM, curcumin encapsulation efficacy, loading capacity, and in vitro release as a function of pH. Free and formulated curcumin were further investigated for cytotoxicity, apoptosis-induction and caspase-8, and 9 activation in chemosensitive HL-60 and its resistant sublines HL-60/Dox and HL-60/CDDP. Formulated curcumin was superior cytotoxic and apoptogenic agent vs. the free drug. The mechanistic assay demonstrated that the potent proapoptotic effects of pH-sensitive liposomal curcumin presumably mediated via recruitment of both extrinsic and intrinsic apoptotic pathways in both HL-60 and HL-60/CDDP cells.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

“…Curcumin has been also documented to exert chemopreventive and drug-resistance modulating activities (Ilieva et al, 2014;Shehzad et al, 2010;Singh and Khar, 2006).…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Curcumin loaded pH-sensitive hybrid lipid/block copolymer nanosized drug delivery systems

Jelezova

Drakalska

Momekova

et al. 2015

European Journal of Pharmaceutical Sciences

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show abstract

“…Curcumin was reported a strong NF-jB inhibitor and apoptosis inducer with antioxidant, cholesterol-lowering, anti-inflammatory, and antimicrobial potential. Ilieva et al (2014) covers the wide spectrum of pleiotropic activities of curcumin, including antitumor effects and protection of the normal bone marrow, besides its antineoplastic property in various malignant cell lines, such as cutaneous T cell lymphoma, acute myeloid leukemia and urinary bladder cancer cells.…”

mentioning

confidence: 99%

Natural products utilization

Georgiev

2014

Phytochem Rev

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Effective co-delivery of doxorubicin and curcumin using a glycyrrhetinic acid-modified chitosan-cystamine-poly(ε-caprolactone) copolymer micelle for combination cancer chemotherapy

Yan

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Antineoplastic potential of curcumin (cooperative study in Bulgaria and Germany)

Cited by 7 publications

References 79 publications

Curcumin loaded pH-sensitive hybrid lipid/block copolymer nanosized drug delivery systems

Curcumin loaded pH-sensitive hybrid lipid/block copolymer nanosized drug delivery systems

Natural products utilization

Effective co-delivery of doxorubicin and curcumin using a glycyrrhetinic acid-modified chitosan-cystamine-poly(ε-caprolactone) copolymer micelle for combination cancer chemotherapy

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