Antinociceptive activity of Hypericum grandifolium Choisy in mice

Bonkanka, C.X.; Sánchez-Mateo, Candelaria Del Carmen; Rabanal, Rosa M.

doi:10.1007/s11418-010-0473-y

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…Furthermore, some Hypericum species, such H. montbretii (Can and Ozkay, ), H. perforatum , and Hypericum hircinum (Diana et al ., ), have been reported to have sedative activity in relation to the CNS. Another CNS‐related activity, centrally mediated antinociception, has been reported in rodents after administration of extracts of Hypericum grandifolium (Bonkanka et al ., ), H. caprifoliatum , Hypericum polyanthemum (Viana et al ., ), H. canariense , H. glandulosum (Rabanal et al ., ), and Hypericum reflexum (Sánchez‐Mateo et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Central Nervous System Activities of Hypericum origanifolium Extract via GABAergic and Opioidergic Mechanisms

Yaşar

Can

Öztürk

et al. 2012

Phytotherapy Research

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Pharmacological effects of hydroalcoholic extract prepared from Hypericum origanifolium Willd. (Guttiferae) on behavioral parameters and pain perceptions of mice were investigated in this study. Depression, anxiety, spontaneous locomotor activity, and motor coordination parameters of mice were assessed by modified forced swimming, hole board, activity cage, and rota-rod tests, respectively. In addition, antinociceptive effect was evaluated by performing hot-plate, tail-clip, and formalin tests. Reboxetine (20 mg/kg), diazepam (1 mg/kg), and morphine (10 mg/kg) were used as reference antidepressant, anxiolytic, and analgesic drugs, respectively. Phytochemical analyses exhibited that chlorogenic acid (2317.12 ppm) and rutin (2108.79 ppm) were the main phenolic compounds in the H. origanifolium extract. The extract (50, 100, and 250 mg/kg) induced significant antidepressant, anxiolytic, and antinociceptive activities following the acute administrations. Anxiolytic effect was antagonized by flumazenil (a benzodiazepine receptor antagonist, 2.5 mg/kg, i.p.) pre-treatment, which indicated the participation of GABA(A)-benzodiazepine receptor complex in the activity. Moreover, centrally and peripherally mediated antinociception reversed by naloxone (a non-selective opioid receptor antagonist, 5 mg/kg, i.p.) pre-treatment, indicating the involvement of opioid system in the pharmacological action. These findings are the first to indicate the pharmacological effects of the H. origanifolium extract on the emotional state and pain perceptions of mice.

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Section: Introductionmentioning

confidence: 99%

Central Nervous System Activities of Hypericum origanifolium Extract via GABAergic and Opioidergic Mechanisms

Yaşar

Can

Öztürk

et al. 2012

Phytotherapy Research

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“…After 5 min, each mouse was placed in a transparent observation cage, and the number of writhing events within 20 min was counted. Body writhing was defined as a contraction of the abdominal muscles together with stretching of the handsaw (Bonkanka et al, 2011).…”

Section: Acetic Acid-induced Writhing Testmentioning

confidence: 99%

Anti-nociceptive effects of Paecilomyces hepiali via multiple pathways in mouse models

Wang

Jia

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Paecilomyces hepiali (PH), a well-known medicinal fungus, has various pharmacological efficacies. In our study, the antinociceptive effects of PH and underlying mechanisms were evaluated using various mouse models. An acetic acid-induced writhing test, hot plate test, and formalin test were employed to evaluate the antinociceptive activities of PH. The levels of neuronal nitric oxide synthase (nNOS) in the hypothalamus and monoamine neurotransmitters in the serum and hypothalamus of experimental mice were examined. Additionally, hot plate tests using mice pretreated with various antagonists were used to determine the mechanisms of PHmediated antinociception. The PH-enhanced latency period of mice in the hot plate test was significantly blocked by pretreatment with atropine and glibenclamide. PH shortened the phase I and phase II reaction times of formalin-treated mice. Strongly reduced writhing and stretching induced by acetic acid were observed in PH-treated mice, indicating that PH mainly exerts antinociceptive activity on neurogenic pain. After thermal pain stimulation for 30 s, compared to control mice, 7-day PH-treated mice had lower nNOS and dopamine levels, and increased levels of serotonin in both the serum and hypothalamus. Collectively, our data showed that PH mediated antinociceptive activities via multiple pathways, including monoamines, nNOS/ATPsensitive K + channels, and M-type acetylcholine receptors.

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“…Furthermore, some Hypericum species, such as H. hircinum and H. perfoliatum (Diana et al, 2007), have been reported to have sedative activity in relation to the CNS. Another CNS-related activity, centrally mediated antinociception, has been reported in rodents after administration of extracts of H. perforatum, H. caprifoliatum, H. polyanthemum (Viana et al, 2003), H. brasiliense (Rieli Mendes et al, 2002), H. triquetrifolium (Apaydin et al, 1999), H. empetrifolium (Trovato et al, 2001), H. reflexum (Sánchez-Mateo et al, 2006), H. canariense, H. glandulosum and H. grandifolium (Bonkanka et al, 2011).…”

Section: Introductionmentioning

confidence: 98%

Effects of Hypericum montbretti Extract on the Central Nervous System and Involvement of GABA (A)/Benzodiazepine Receptors in its Pharmacological Activity

Can

Özkay

2012

Phytotherapy Research

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The present study was undertaken to investigate the putative activity of a methanol extract of Hypericum montbretti (Guttiferae) on the central nervous system. Rutin (1519 ppm) and quercitrin (784 ppm) were identified as the major phenolic compounds in the extract. When administered at 25, 50 and 100 mg/kg doses, the extract decreased the total number of head-dipping behaviours performed by mice during a hole-board test. Administration of both the extract and diazepam (2 mg/kg) reduced spontaneous locomotory activity, potentiated hexobarbital (60 mg/kg)-induced sleeping parameters and prevented pentylenetetrazole (80 mg/kg)-induced seizures relative to the controls. These findings are the first to indicate the sedative and anticonvulsant activities of H. montbretti extract. Atropine (2 mg/kg) and naloxone (5 mg/kg) pre-treatment did not reverse the sedative effect, indicating that muscarinic and opioidergic mechanisms did not contribute to the pharmacological action. However, pre-treatment with flumazenil (a benzodiazepine receptor antagonist) reversed both the sedative and anticonvulsant effects induced by a 100 mg/kg dose of the extract, indicating the involvement of the GABA(A)-benzodiazepine receptor complex. In conclusion, H. montbretti extract is a novel candidate as a sedative and anticonvulsant drug for the treatment of sleep disorders and for the prevention of epileptic seizures.

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Antinociceptive activity of Hypericum grandifolium Choisy in mice

Cited by 9 publications

References 33 publications

Central Nervous System Activities of Hypericum origanifolium Extract via GABAergic and Opioidergic Mechanisms

Central Nervous System Activities of Hypericum origanifolium Extract via GABAergic and Opioidergic Mechanisms

Anti-nociceptive effects of Paecilomyces hepiali via multiple pathways in mouse models

Effects of Hypericum montbretti Extract on the Central Nervous System and Involvement of GABA (A)/Benzodiazepine Receptors in its Pharmacological Activity

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