Antinociceptive activity of Inula britannica L. and patuletin: In vivo and possible mechanisms studies

Zarei, Mohammad; Mohammadi, Seyed Abolghasem; Komaki‬, Alireza

doi:10.1016/j.jep.2018.03.021

Cited by 37 publications

(22 citation statements)

References 39 publications

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“…The tandem mass analysis of the medicinal herb extracts is shown in Table 2. The phenolic and other phytochemical compounds detected here are in accordance with the results reported in previous studies [12–20, 33–42]. Five compounds were detected in the B. juncea extracts , including sinigrin, a member of the glucosinolate family [34].…”

Section: Resultssupporting

confidence: 91%

“…Forsythia suspensa is known for its high saponin content and is used to treat various inflammatory symptoms, such as carbuncles or abscesses associated with swelling, common cold, and fever [11]. Inula britannica, a rich source of flavonoids [12–20], is used as a traditional medicine to treat bronchitis, digestive disorders, and inflammation in Korea [12]. Considering these phytochemical properties, its antimicrobial effects against Helicobacter pylori [21] and its potential as a food additive in cheddar-type cheese [22] have been studied previously.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Brassica juncea, Forsythia suspensa, and Inula britannica: phytochemical properties, antiviral effects, and safety

Bae

Kim

Choi

et al. 2019

BMC Complement Altern Med

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Background General antiviral agents such as oseltamivir are associated with certain adverse effects and the emergence of resistance. This study investigated the phytochemical properties, antiviral activities, and safety of three herbs used in traditional Korean medicine. Methods Extracts of three medicinal herbs (Brassica juncea, Forsythia suspensa, and Inula britannica) were prepared using ethanol or water. The total phenolic, flavonoid, and saponin content, condensed tannin content, and reducing sugar content of the herb extracts were determined via phytochemical screening. Tandem mass analysis was performed using an ultra-performance liquid chromatography (UPLC)-electrospray ionization (ESI)-Q/Orbitrap instrument. Virus titrations were determined via tissue culture infective dose (TCID50) and cytotoxicity assays. Hemolysis and hepatotoxicity were measured to determine safety. Results Among the three medicinal herbs, F. suspensa showed the highest concentration of phenolic compounds, flavonoids, and saponins. The number of phytochemical compounds detected via tandem mass analysis of B. juncea, F. suspensa, and I. britannica was 5 (including sinigrin, m/z [M-H] = 358.02), 14 (including forsythoside A, m/z [M-H] = 623.19), and 18 (including chlorogenic acid, m/z [M-H] = 353.20), respectively. The antiviral effects of the B. juncea extracts (ethanol and water) and I. britannica extract (ethanol) were further investigated. The ethanol extract of B. juncea showed a 3 Log TCID50/25 μL virus titration reduction and the water extract showed a selectivity index of 13.668 against infected influenza H1N1 virus A/NWS/33. The B. juncea extracts did not show hemolysis activities and hepatotoxicity (< 20%). The ethanol extract of I. britannica showed the most effective virus titration decrease, whereas its hemolytic and hepatotoxicity values were the most significantly different compared to the control. Despite the high concentration of phytochemicals detected in F. suspensa, the extract showed approximately 1 Log TCID50/25 μL at the highest concentration. Conclusion B. juncea may show antiviral effects against H1N1 in a host. In addition, B. juncea may also show decreased disadvantages compared to other antiviral agents.

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Investigation of Brassica juncea, Forsythia suspensa, and Inula britannica: phytochemical properties, antiviral effects, and safety

Bae

Kim

Choi

et al. 2019

BMC Complement Altern Med

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“…Potentilla anserina (Rosaceae) is traditional medicinal plant available in India and Northern hemispheres often on river shores and grassy habitats. Plants which are reported to have antiinflammatory and antinociception activity include Syzygium cerasoideum 3 , Potentilla reptans 4 , Inula britannica 5 , Coriandrum sativum 6 , Clinacanthus nutans 7 , Borreria verticillata 8 , Sonchus asper 9 , Inula helenium 10 , Erigeron acer 11 , Rhus coriaria 12 , Ducrosia anethifolia 13 , Eryngium pyramidal Boiss 14 , Pimpinella anisum 15 , Tanacetum balsamita 16 , Echinophora platyloba 17 and Lemon verbena 18, etc. There is a growing interest in the pharmacological evaluation of various plants used in traditional Indian systems of medicine.…”

Section: (4)1760-64mentioning

confidence: 99%

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2019

IJPSR

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Potentilla anserina (Rosaceae) is a traditional medicinal plant in India, and it is available throughout the Northern hemisphere. This study was intended to evaluate the antinociceptive activity of methanolic extract of Potentilla anserina in acetic acid-induced writhing test in mice and Eddy's Hot Plate method in Albino rats at the dose level of 75, 150 and 300 mg/kg p.o and the study was compared with the standard drug Indomethacin 10 mg/kg. The data were expressed as mean ± S.E.M. The statistical analysis was done using ANOVA followed by Dunnett"s post hock test. The methanolic extract of Potentilla anserina showed significant antinociceptive activity in the acetic acid-induced writhing method the PAME (75, 150, 300 mg/kg, p.o) 1hr before a pain stimulus significantly reduced the nociceptive response. In the hot plate method, there was no significant difference in nociceptive behavior. The antinociceptive activity could be associated with the presence of several flavonoid-based bioactive compounds and their synergistic action with non-volatile bioactive compounds.

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“…It has been used to treat bronchitis, arthritis and digestive disorders (Zarei et al . 2018). Our previous study showed that I. brtiannica inhibits Helicobacter pylori in gastric conditions, and has effects on urease activity, adhesion and detachment in AGS cell lines (Lee et al .…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial effects of three herbs ( Brassica juncea , Forsythia suspensa , and Inula britannica ) on membrane permeability and apoptosis in Salmonella

Bae

Kim

et al. 2020

J Appl Microbiol

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Aims This study aimed synergistic effects of three herbs in Salmonella via increased membrane permeability and apoptosis. Methods and Results Using high‐performance liquid chromatography, four types of phenylethyl glycosides and a lignan were detected in the herb mixture (Brassica juncea, Forsythia suspensa, and Inula britannica). During treatment with the herb mixture (1×, 2×, or 4× the MIC), viable cells decreased to 1·87 log CFU per ml (Salmonella Gallinarum) and 2·33 log CFU per ml (Salmonella Enteritidis) after 12 h of incubation according to inhibition of tricarboxylic acid cycle (P < 0·01). In addition, N‐phenyl‐1‐naphthylamine uptake increased from 229·00 to 249·67 AU in S. Gallinarum and from 232·00 to 250·67 AU in S. Enteritidis (P < 0·05), whereas membrane potential decreased from 8855·00 to 3763·25 AU and from 8703·67 to 4300·38 AU, respectively. Apoptotic Salmonella cells were observed by confocal laser scanning microscopy and flow cytometry. Transmission electron microscopy observations with negative staining showed protein leakage from damaged Salmonella. Conclusions These results showed the synergistic effect of the three herbs against avian pathogenic Salmonella induced by membrane damage and apoptosis. Significance and Impact of the Study Salmonella causes enormous economic losses in the poultry industry. These results indicated that potency of natural antimicrobial agents due to apoptosis in Salmonella.

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Antinociceptive activity of Inula britannica L. and patuletin: In vivo and possible mechanisms studies

Cited by 37 publications

References 39 publications

Investigation of Brassica juncea, Forsythia suspensa, and Inula britannica: phytochemical properties, antiviral effects, and safety

Investigation of Brassica juncea, Forsythia suspensa, and Inula britannica: phytochemical properties, antiviral effects, and safety

Untitled

Antimicrobial effects of three herbs ( Brassica juncea , Forsythia suspensa , and Inula britannica ) on membrane permeability and apoptosis in Salmonella

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