No abstract

Background:The drive toward the use of medicinal plants has been increasing in recent years. They have few side effects and a large variety of efficient components.Objectives:This study was designed to investigate the analgesic effects of hydroalcoholic Rhus coriaria leaf extract (HRCLE) in a rat model.Materials and Methods:A total of 42 adult male rats were divided into seven groups: a control group (the animals did not receive any drug), three HRCLE groups, (receiving 80, 100, and 300 mg/kg, intraperitoneally [ip]), a morphine group (1 mg/kg, ip) an aspirin group (1 mg/kg, ip), and a group that received 300 mg/kg of HRCLE plus naloxone (1 mg/kg, ip). The analgesic effects of HRCLE were assessed via writhing, tail flick, and formalin tests, and the data obtained were compared with the control group using one-way analysis of variance and Tukey post hoc tests.Results:HRCLE significantly inhibited the number of contractions induced by acetic acid in the writhing test at all doses, while anti-nociceptive activity was only shown at the 100 mg/kg dose (in the chronic phase) and at the 300 mg/kg dose (in the chronic-acute phase) in the formalin test. Interestingly, the greatest effect was observed at the 300 mg/kg HRCLE dose in the tail flick test. Simultaneous utilization of naloxone and HRCLE inhibited the anti-nociceptive effect of the extract in all tests. It is worth mentioning that aspirin and morphine revealed anti-nociceptive effects in all tests.Conclusions:Our findings suggest that the analgesic effect of HRCLE may be mediated via both peripheral and central mechanisms. The presence of flavonoids might be responsible for the anti-nociceptive activity of this plant.

Background: The fundamental problems with the personality disorders diagnostic system in DSM-IV led to the revision of the DSM approach and proposition of a dimensional model for DSM-5. The DSM-5 Personality and personality disorders workgroup developed the personality inventory for DSM-5 (PID-5) to assess the pathological personality traits within this new model. Objectives: The purpose of this study was to investigate the psychometric properties of PID-5 in psychiatric patients. Methods: In a cross-sectional study, the Persian translation of the PID-5 was administered to 400 psychiatric patients admitted to the Roozbeh Hospital. After data collection, the reliability of the inventory was investigated using internal consistency and test-retest methods. In addition, confirmatory factor analysis and convergent validity methods were used to evaluate the validity of the scale. Results: Adequate internal consistency coefficients were obtained for domains and facets. In addition, the test-retest coefficients (up to 0.70) suggested scale stability. Confirmatory factor analysis supported the original five-factor model of the inventory. The convergent validity of the inventory with the TCI-R scale was appropriate. Conclusions: The results of the study supported the psychometric properties of the Persian version of PID-5 in psychiatric populations.

No abstract