Effect of Hydroalcoholic Leaves Extract of Rhus Coriaria on Pain in Male Rats

Abstract

Background:The drive toward the use of medicinal plants has been increasing in recent years. They have few side effects and a large variety of efficient components.Objectives:This study was designed to investigate the analgesic effects of hydroalcoholic Rhus coriaria leaf extract (HRCLE) in a rat model.Materials and Methods:A total of 42 adult male rats were divided into seven groups: a control group (the animals did not receive any drug), three HRCLE groups, (receiving 80, 100, and 300 mg/kg, intraperitoneally [ip]), a morphine group (1 mg/kg, ip) an aspirin group (1 mg/kg, ip), and a group that received 300 mg/kg of HRCLE plus naloxone (1 mg/kg, ip). The analgesic effects of HRCLE were assessed via writhing, tail flick, and formalin tests, and the data obtained were compared with the control group using one-way analysis of variance and Tukey post hoc tests.Results:HRCLE significantly inhibited the number of contractions induced by acetic acid in the writhing test at all doses, while anti-nociceptive activity was only shown at the 100 mg/kg dose (in the chronic phase) and at the 300 mg/kg dose (in the chronic-acute phase) in the formalin test. Interestingly, the greatest effect was observed at the 300 mg/kg HRCLE dose in the tail flick test. Simultaneous utilization of naloxone and HRCLE inhibited the anti-nociceptive effect of the extract in all tests. It is worth mentioning that aspirin and morphine revealed anti-nociceptive effects in all tests.Conclusions:Our findings suggest that the analgesic effect of HRCLE may be mediated via both peripheral and central mechanisms. The presence of flavonoids might be responsible for the anti-nociceptive activity of this plant.

Pharmacological and Antioxidant Activities of Rhus coriaria L. (Sumac)

“…This sumac-modulated reduction in writhing was concomitant with the increase in the tail-flick time and inhibition of both phases of the formalin test, suggestive of an antinociceptive effect of Rhus coriaria . Hence, these results allude to the notion that the pain-relieving effect of sumac may be mediated through both peripheral and central mechanisms [ 101 ]. Based on these findings, Rhus coriaria can be a potential source for the novel, natural, and safe compounds with an analgesic effect and thus deserves further investigation in clinical trials.…”

“…Therefore, the focus toward the use of medicinal plants has been increasing in recent years. A study investigating the analgesic effects of Rhus coriaria hydroalcoholic leaf extract showed a significant reduction in writhing in Wistar rats pretreated with sumac extract [ 101 ]. This sumac-modulated reduction in writhing was concomitant with the increase in the tail-flick time and inhibition of both phases of the formalin test, suggestive of an antinociceptive effect of Rhus coriaria .…”

Evaluation of Anti-inflammatory Activity of Methanol Extract of Rhus coriaria L. in Diabetic Rats

“…This agrees with previous study that showed the extract is non-toxic even at doses higher than 800 mg/kg body weight. 43 Antiproliferative assay Fibroblast cell proliferation was stimulated when treated with 100 mg/mL of R. coriaria extract after 24 hours compared to the control group. The cytotoxicity activity of methanol extract of R. coriaria against fibroblasts revealed that 100 µ/mL of R. coriaria extract resulted in very low cytotoxicity against fibroblasts with 40.12%, and IC50 of 108.4 µ/mL.…”

Untitled

“…Potentilla anserina (Rosaceae) is traditional medicinal plant available in India and Northern hemispheres often on river shores and grassy habitats. Plants which are reported to have antiinflammatory and antinociception activity include Syzygium cerasoideum 3 , Potentilla reptans 4 , Inula britannica 5 , Coriandrum sativum 6 , Clinacanthus nutans 7 , Borreria verticillata 8 , Sonchus asper 9 , Inula helenium 10 , Erigeron acer 11 , Rhus coriaria 12 , Ducrosia anethifolia 13 , Eryngium pyramidal Boiss 14 , Pimpinella anisum 15 , Tanacetum balsamita 16 , Echinophora platyloba 17 and Lemon verbena 18, etc. There is a growing interest in the pharmacological evaluation of various plants used in traditional Indian systems of medicine.…”