Antinociceptive activity of the monoterpene <i>α</i>-phellandrene in rodents: possible mechanisms of action

Lima, David Fernandes; Brandão, Marcela S.; Moura, Joelma B; Leitão, Joseana M R S; Carvalho, Fernando Aécio de Amorim; Miura, Leiz M. C. V.; Leite, José Roberto S. A.; Sousa, Damião Pergentino de; Almeida, Fernanda Campos Sousa de

doi:10.1111/j.2042-7158.2011.01401.x

Cited by 69 publications

(53 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most of the components identified for these two EOs has proven antinociceptive effects in different animal models. 1,8‐cineole, α‐terpineol, phellandrene and others presented depressant effects on the central nervous system, suggesting an anaesthetic property (Santos & Rao ; Lima, Brandão, Moura, Leitão, Carvalho, Miúra, Leite, Sousa & Almeida ; Watt, Betts, Kotey, Humbert, Griffith, Kelly, Veneskey, Gill, Rowan, Jenkins & Hall ). However, the pharmacological mechanisms of this action still needs to be elucidated, since, according to Guimarães, Quintans and Quintans‐Junior (), many terpenes presented more than one mechanism of action to produce their effects.…”

Section: Discussionmentioning

confidence: 99%

Anaesthetic and antioxidant effects ofMyrcia sylvatica(G. Mey.)DC. andCurcuma longaL. essential oils on tambaqui (Colossoma macropomum)

et al. 2016

View full text Add to dashboard Cite

Anaesthetic substances are necessary to reduce fish stress during aquaculture activities. The objectives of this study were: (i) to determine the efficacy of essential oils (EOs) of Myrcia sylvatica (EOMS) and Curcuma longa (EOCL) as anaesthetics for Colossoma macropomum and (ii) to evaluate the effects of rapid anaesthesia and long-term sedation (6 h) with these oils. Therefore, the main primary stress indicator (cortisol) and secondary factors (biochemical indices, hepatic metabolism, oxidative biomarkers) were measured. Sedation with the EOCL resulted in lower cortisol levels compared to control group. Total cholesterol levels were lower in fish sedated with EOMS than in control. Lactate levels were higher in fish anaesthetized with both EOs and sedated with EOCL compared to control. Both EOs increased hepatic glycogen levels after anaesthesia and EOMS increased this parameter after sedation compared to control. Anaesthesia and sedation with EOs resulted in lower levels of lipid peroxidation (LPO) compared to control. In turn, the activity of some antioxidant enzymes evaluated (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase), the content of non-protein thiols and total reactive antioxidant potential were higher in tissues of fish anaesthetized and sedated with EOs compared to control. This induction of antioxidant capacity in the tissues could be due to the antioxidant property exerted by these EOs. Thus, EOMS and EOCL are recommended for anaesthesia and sedation of fish because in spite of inducing anaerobic metabolism, these EOs did not alter most biochemical parameters, reduced the LPO and increased the antioxidant capacity in vital tissues.

show abstract

Section: Discussionmentioning

confidence: 99%

Anaesthetic and antioxidant effects ofMyrcia sylvatica(G. Mey.)DC. andCurcuma longaL. essential oils on tambaqui (Colossoma macropomum)

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Germacrenes are known for their cytotoxic and anticancer, anti-parasites and anti-inflammatory activities (Adio, 2009;Vandermoten et al, 2011). Phellandrenes are recognized for their antimicrobial, pain-inhibition and promotion of immune responses (Iscan et al, 2012;Lima et al, 2012;Lin et al, 2013). The presence of these new compounds or the change of other volatiles' concentration could add more medicinal and pharmacological properties for Eucalyptus.…”

Section: Reuse and Recycle Of Attacked Eucalyptusmentioning

confidence: 99%

The interaction between the gall wasp Leptocybe invasa and Eucalyptus camaldulensis leaves: A study of phyto-volatile metabolites

Mohamed¹

2016

J. Pharmacognosy Phytother.

View full text Add to dashboard Cite

A comparative study of the volatile terpene fraction isolated from the leaves of Eucalyptus camaldulensis attacked by the gall wasp (Leptocybe invasa) and from the healthy leaves of the plant was carried out using gas chromatography-mass spectrometry. A total of 59 components representing 89.13 and 88.6%, respectively, of their total volatile fraction contents were analyzed. Of these volatiles, 26 compounds with concentrations greater than (0.1± 0.02%) have been used for statistical comparison. A number of 21of these compounds were identified, in different concentrations, in the leaves volatile fraction of both healthy plants and plants attacked by the wasps. The other 5 volatiles: p-mentha-2-4(8) diene, δ-elemene, β-elemene, E-caryophyllene and bicyclogermacrene, were exclusively found in the volatile fraction of the attacked leaves. The newly produced compounds in the attacked leaves or the change in concentration of those commonly found in that fraction, could be part of the plant defense mechanisms, or/and an element of the plant allelopathic and communication mechanisms. Identifying the components of the gall wasp-damaged leaves can help in their recycling for different physiological, pharmacological and medicinal uses.

show abstract

“…3,4 Assim, a fitoterapia é um método racional e alopático, baseado em evidências científicas, empregado no tratamento médico de váriaspatologias. 5 Um levantamento bibliográfico cobrindo apenas os primeiros meses de 2012 e considerando apenas o mecanismo de ação dos princípios ativos envolvidos, mostra a eficácia das plantas medicinais no tratamento da doença de Alzheimer [6][7][8] , de doenças cardíacas [9][10][11][12] , da malária 13,14 , da leishmania 15 , da esquistossomose 16 , do câncer [17][18][19][20][21][22] , do herpes anti-inflamatório [26][27][28] , como antiúlcera 28,29 ,como antinociceptivo 30 , como antidiabético 31,32 e antidiurético 33 .…”

Section: Introductionunclassified

Production of Phytotherapeutics in Brazil: History, Problems and Perspectives

Alves¹

2013

Revista Virtual De Química

View full text Add to dashboard Cite

Antinociceptive activity of the monoterpene α-phellandrene in rodents: possible mechanisms of action

Abstract: α-PHE has an antinociceptive effect and it possibly involves the glutamatergic, opioid, nitrergic, cholinergic and adrenergic systems.

Cited by 69 publications

References 50 publications

Anaesthetic and antioxidant effects ofMyrcia sylvatica(G. Mey.)DC. andCurcuma longaL. essential oils on tambaqui (Colossoma macropomum)

Anaesthetic and antioxidant effects ofMyrcia sylvatica(G. Mey.)DC. andCurcuma longaL. essential oils on tambaqui (Colossoma macropomum)

The interaction between the gall wasp Leptocybe invasa and Eucalyptus camaldulensis leaves: A study of phyto-volatile metabolites

Production of Phytotherapeutics in Brazil: History, Problems and Perspectives

Contact Info

Product

Resources

About