Antinociceptive and anti-inflammatory activities of Phlomis umbrosa Turcz extract

Shang, Xiaofei; Wang, Jinhui; Li, Maoxing; Miao, Xiangshui; Hu, Pan; Yang, Yaoguang; Wang, Yu

doi:10.1016/j.fitote.2011.03.001

Cited by 59 publications

(37 citation statements)

References 14 publications

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“…The basal reaction time was recorded by observing tail flick response [27] in animals when the tail was immersed in water maintained at constant temperature (55°C). Normally, animals show such response in 3-5 s. A cut-off period of 10 s was observed to avoid tissue damage.…”

Section: Tail Immersion Methodsmentioning

confidence: 99%

Anti-inflammatory and antinociceptive activities of H. schulli seed extracts

Kannur¹,

Paranjpe²,

Dongre³

et al. 2012

Int J Green Pharm

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The study was undertaken to investigate and compare in vitro anti inflammatory activities of five varieties of hexane and methanol seed extracts each, specifically Artocarpus heterophyllus, Artocarpus integrifolia, Artocarpus hirsitus, Artocarpus inciscus and Artocarpus integer of Artocarpus species belonging to the family Moraceae by means of most prominent membrane stability assay. Results revealed that, the percentage of membrane stability exhibited by the test samples were concentration dependent and compared constructively with that of standard Diclofenac. Amongst two extracts methanolic seed extracts had highest percentage of inhibition and in both extracts Artocarpus integer had uppermost membrane stabilization capacity. The statistical analysis with student 't' test showed significant difference for tested factors in between hexane and methanolic seed extract groups. The study disclosed that Artocarpus seed extracts could be seen as a potential natural source of membrane stabilizer and was capable of providing an alternative remedy for the management and source of membrane stabilizer and further studies were suggested to isolate the active principles responsible for the bustle.

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Section: Tail Immersion Methodsmentioning

confidence: 99%

Anti-inflammatory and antinociceptive activities of H. schulli seed extracts

Kannur¹,

Paranjpe²,

Dongre³

et al. 2012

Int J Green Pharm

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“…또한 전문에 걸쳐 다른 생약제제와 같이 사용하여 난 소적출 동물 모델에서 골밀도 증가효과를 확인한 논문도 보고되 어 있다 (11). 한속단(Phlomis umbrosa)은 꿀풀과(Lamiaceae)과에 속 하는 다년생식물로 진통 (12), 염증 (13), 알레르기(14-15) 등에 효과 가 있는 것으로 알려져 있으며 이 외에도 골밀도를 증가시키고 골절에 의한 뼈 손상을 돕는다는 연구결과가 알려져 있다 (16)(17) Fig. 1).…”

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Mixture of Extracts of Cynanchum wilfordii and Phlomis umbrosa Turcz. Does Not Have an Estrogenic Effect in Ovariectomized Rats

Han¹,

Lee²,

Jang³

et al. 2015

Korean Journal of Food Science and Technology

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Cynanchum wilfordii and Phlomis umbrosa Turcz. are known to contain isoflavone, a representative phytoestrogen. This study was performed to determine whether the extract mixture of C. wilfordii and P. umbrosa Turcz. would induce an estrogenic effect in ovariectomized rats. The extracts were administered to the ovariectomized rats at 30, 60, 120 mg/ kg per day for 4 weeks, respectively. They showed no estrogenic effect, which was indicated by the decrease in uterus wall thickness as well as the increase in body weight and the level of cholesterol and triglyceride. The extracts also had no effect on the concentrations of estrogen and growth hormone in the serum. However, the increase in alkaline phosphatase activity, which leads to protection against the bone loss caused by ovariectomy, was noted on administration of the extract. Therefore, it seemed that the extracts of C. wilfordii and P. umbrosa Turcz. had no estrogenic effect in rats.

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“…Based on the essential oils and metabolites, Phlomis species have been reported for both anti-inflammatory and tonic properties (Aligiannis et al, 2004;Amor et al, 2009;Shang et al, 2011;Tammaro & Xepapadakis 1986;Ullah et al, 2011). Studies on P. lanata are also limited to essential oils (Couladis et al, 2000(Couladis et al, , 2003.…”

Section: Resultsmentioning

confidence: 99%

“…Phlomis species have been reported for both anti-inflammatory and tonic properties (Aligiannis et al, 2004;Amor et al, 2009;Shang et al, 2011;Tammaro & Xepapadakis, 1986;Ullah et al, 2011). In fact, tonic properties have been reported for many other plant species.…”

Section: Discussionmentioning

confidence: 99%

T cell regulation byPhlomis lanataprotein extracts in mice

Karali

Georgescu

Pirintsos

et al. 2015

Pharmaceutical Biology

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Context: Phytopharmacology is a complex but very promising research area. The different plant parts and extraction methods may result in opposed effects. Phlomis species have been reported for both anti-inflammatory and tonic properties. Objective: The effect of Phlomis lanata Willd. (Lamiaceae) protein extracts on immune cell reactivity was studied in the experimental mouse model. Materials and methods: Protein extracts from P. lanata aerial parts were fractionated by Q-sepharose ion-exchange chromatography and applied to whole spleen cells or T-cell subsets at 5 mg/ml. Cell growth and cytokine production were evaluated after 4 and 2 d of culture using 3 H-thymidine-uptake and ELISA techniques, respectively. Results: Among the protein fractions tested, column wash proteins (W1) and the fraction eluted using 600 mM NaCl (F6) reduced by 76% and increased by 78% spleen cell proliferation, respectively. W1 suppressed proliferation of effector T-cells, but stimulated the growth of suppressor/regulatory cells by 62-148%. Although W1 stimulated IL-2 and IL-10 production from total spleen cells, it significantly increased IL-10 (50%) and reduced IL-2 (30-50%) production from T-cells, while TNF-a release was enhanced in CD25 + CD4 + by 92% and reduced by 50% in CD25 + CD8 + cells. F6 stimulated whole spleen cell growth, reduced proliferation of CD8 + and CD25 + cells by approximately 50%, while decreasing by 60-80% TNF-a production from CD25À and CD25 + CD8 + cells. Discussion and conclusion: The suppressive activity of W1 could be attributed to IL-10 and TNF-a, while the stimulatory effect of F6 could be attributed to the inhibition of T-regulatory cells. In the same plant, coexisting protein fractions induce both immunostimulatory and immunosuppressive activities.

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Antinociceptive and anti-inflammatory activities of Phlomis umbrosa Turcz extract

Cited by 59 publications

References 14 publications

Anti-inflammatory and antinociceptive activities of H. schulli seed extracts

Anti-inflammatory and antinociceptive activities of H. schulli seed extracts

Mixture of Extracts of Cynanchum wilfordii and Phlomis umbrosa Turcz. Does Not Have an Estrogenic Effect in Ovariectomized Rats

T cell regulation byPhlomis lanataprotein extracts in mice

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