In the present work, Caesalpinia bonduc seed coat extract (CBSCE) has been evaluated for anti-inflammatory and analgesic activity C. bonduc seeds have been attributed with anti-inflammatory and analgesic properties in the folklore medicine. Here in our study, we have tried to carry out the systematic evaluation of the seed coat extract of C. bonduc to substantiate these claims. C. bonduc seed coat was extracted with 95% ethanol and concentrated; further, the extract was screened for anti-inflammatory and analgesic activity. The studies were carried using Carrageenan-induced Paw Edema, Egg albumin-induced paw edema, Eddy's Hot Plate Test, Tail Immersion Method so as to prove acclaimed properties. The data was analyzed statistically by Students’ ‘t’ test. The results indicate that seed coat extract has the ability to decrease the induced inflammation at varied doses in Carrageenan model as well as in the Egg albumin model in rats. The antinociceptive results indicate that the extract has the ability to increase the pain threshold of the animals and reduce the pain factor, thereby inducing analgesia. Thus, it can be concluded that CBSCE posses analgesic and anti-inflammatory activity.
The study was undertaken to investigate and compare in vitro anti inflammatory activities of five varieties of hexane and methanol seed extracts each, specifically Artocarpus heterophyllus, Artocarpus integrifolia, Artocarpus hirsitus, Artocarpus inciscus and Artocarpus integer of Artocarpus species belonging to the family Moraceae by means of most prominent membrane stability assay. Results revealed that, the percentage of membrane stability exhibited by the test samples were concentration dependent and compared constructively with that of standard Diclofenac. Amongst two extracts methanolic seed extracts had highest percentage of inhibition and in both extracts Artocarpus integer had uppermost membrane stabilization capacity. The statistical analysis with student 't' test showed significant difference for tested factors in between hexane and methanolic seed extract groups. The study disclosed that Artocarpus seed extracts could be seen as a potential natural source of membrane stabilizer and was capable of providing an alternative remedy for the management and source of membrane stabilizer and further studies were suggested to isolate the active principles responsible for the bustle.
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