Evaluation of Caesalpinia bonduc seed coat extract for anti-inflammatory and analgesic activity

Abstract

In the present work, Caesalpinia bonduc seed coat extract (CBSCE) has been evaluated for anti-inflammatory and analgesic activity C. bonduc seeds have been attributed with anti-inflammatory and analgesic properties in the folklore medicine. Here in our study, we have tried to carry out the systematic evaluation of the seed coat extract of C. bonduc to substantiate these claims. C. bonduc seed coat was extracted with 95% ethanol and concentrated; further, the extract was screened for anti-inflammatory and analgesic activity. The studies were carried using Carrageenan-induced Paw Edema, Egg albumin-induced paw edema, Eddy's Hot Plate Test, Tail Immersion Method so as to prove acclaimed properties. The data was analyzed statistically by Students’ ‘t’ test. The results indicate that seed coat extract has the ability to decrease the induced inflammation at varied doses in Carrageenan model as well as in the Egg albumin model in rats. The antinociceptive results indicate that the extract has the ability to increase the pain threshold of the animals and reduce the pain factor, thereby inducing analgesia. Thus, it can be concluded that CBSCE posses analgesic and anti-inflammatory activity.

Antibacterial activities of the seed extracts of some indigenous plants

“…Kannur et al (2012) reported that the seed coat extracts of C. bonduc was more effective in controlling the inflammation. Cerqueira et al (2009) extracted, purified and characterized galactomannans from non-traditional sources.…”

Evaluation of Caesalpinia bonducella flower extract for anti-inflammatory action in rats and its high performance thin layer chromatography chemical fingerprinting

“…Potent anti-inflammatory activity of C. bonducella seed coat extract has been reported. [ 19 ] Autacoids are one of the most important mediators of inflammation. They sensitize the nerve ending for pain sensation and enhance the inflammatory mediators to be released at the site of insult.…”

Review on Caesalpinia bonducella

“…aesalpinia bonducella L. plant ( fig.1) is also known as "fever nut", belongs to family caesalpiniaceae. [1][2][3] C. bonducella is a huge thorny shrub known to be a local of South India, Burma and Ceylon, especially along the ocean drift and up to 2500 ft. in hilly regions. 4 C. bonducella used as a herbal medicine derived from Kingdom: Plantae, Order: Febales, Family: Caesalpiniacaeae, Genus: Caesalpinia, Species: C. bonducella; Part used: Seeds (Fig.2) of C. bonducella commonly known as Kakachika, Karanja.…”