Antinociceptive and anti-inflammatory activities of Schefflera octophylla extracts

Chen, Yanfen; Tao, Shu-Hong; Zeng, Fanlin; Xie, Luwei; Shen, Zhi-Bin

doi:10.1016/j.jep.2015.04.050

Cited by 25 publications

(10 citation statements)

References 20 publications

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“…Now a days researchers are engaged in evaluation of biological activities possessed by these plant derived natural products. 3 The identification of such natural products which possess lesser side effects and no addictive potential like opioids could play an important role in treatment of pain disorders and inflammation.…”

Section: Introductionmentioning

confidence: 99%

Studies on analgesic, anti-inflammatory activities of stem and roots of Inula cuspidata C.B Clarke

Paliwal

Sati

Faujdar

et al. 2017

Journal of Traditional and Complementary Medicine

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The present study was carried out to evaluate analgesic and anti-inflammatory activities in Inula cuspidata stem and root extracts along with heavy metals estimation in stem and root powder.Stem and roots were extracted with chloroform (ICSCE, ICRCE) and methanol (ICSME, ICRME). Acute oral toxicity of all extracts was determined by OECD guidelines 425. Analgesic activity was investigated by using hot plate and acetic acid induced writhing models. Anti-inflammatory activity (acute) of all extracts was evaluated by carrageenan induced paw edema model. In addition, root and stem powder was screened for heavy metals (As, Pb, Cd, Hg) estimation using atomic absorption spectroscopy. In acute toxicity study no mortality was observed when each extract was orally administered with 2.0 g/kg. At the doses (100 and 200 mg/kg) ICRME followed by ICSME showed significant and dose dependent analgesic and anti-inflammatory effects compared with chloroform extracts. The heavy metals concentration in stem and root powders was found to be within the permissible limits as recommended by WHO for herbal raw materials. The findings of the present study validated the folkloric use of Inula cuspidata as analgesic and anti-inflammatory. In addition, the results intimate that heavy metals present in raw material were found to be within the defined limits, and it exhibits that the therapeutic efficacy of plant may not be effected, which can be otherwise possibly effected if the plant sequester high concentration of heavy metals from the polluted environment as well as from the soil rich in pesticides and sewage sludge etc.

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Section: Introductionmentioning

confidence: 99%

Studies on analgesic, anti-inflammatory activities of stem and roots of Inula cuspidata C.B Clarke

Paliwal

Sati

Faujdar

et al. 2017

Journal of Traditional and Complementary Medicine

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“…ACK (3α‐hydroxy‐lup‐20(29)‐ene‐23,28‐dioic acid) is a pentacyclic compound isolated from diverse plants, initially from the leaves of Scheflera octophylla (Araliaceae) used in Vietnamese folk medicine 40,41 . The antinociceptive and anti‐inflammatory activities of S. octophylla extracts have been well characterized, and diverse ACK‐based glycosides (see below) have been isolated from this plant 42–44 . ACK was later found in Schefflera actinophylla , 45,46 in the leaves of Oplopanax horridus , 47 and in the leaves and roots of plants of the Acanthopanax family, such as A. gracilistylus , A. koreanum , and A. trifoliatus (Fig.…”

Section: Ack and Related Sapogeninsmentioning

confidence: 99%

Acankoreagenin and acankoreosides, a family of lupane triterpenoids with anti‐inflammatory properties: an overview

Bailly¹

2021

Annals of the New York Academy of Sciences

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Acankoreagenin (ACK, also known as acankoreanogenin and HLEDA) and impressic acid are two lupane‐type triterpenes that can be isolated from various Acanthopanax and Schefflera species. They efficiently block activation of the NF‐κB signaling pathway and the release of proinflammatory cytokines and/or the action of inflammation mediators (HMGB1, iNOS, and NO). These effects are the basis for the antiviral and anticancer activities reported with these pentacyclic compounds or their various glycoside derivatives. More than 15 acankoreosides (Ack‐A to ‐O, and ‐R) and a few other mono‐ and bidesmosidic saponins (acantrifoside A and acangraciliside S) derive from the ACK aglycone. Compounds like Ack‐A and ‐B are remarkable anti‐inflammatory agents, inhibiting cytokine release from activated macrophages. Despite their effectiveness, ACK and impressic acid are far much less known and studied than the structurally related compounds betulinic acid and 23‐hydroxybetulinic acid (anemosapogenin). The structural differences (notably the R/S stereoisomerism of the 3‐hydroxyl group) and functional similarities of these compounds are discussed. The complete series of acankoreosides is presented for the first time. These natural products deserve further attention as anti‐inflammatory agents, and ACK is recommended as a template for the design of new anticancer and antiviral drugs.

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“…Prostacyclin (PGI 2 ) could effectively inhibit platelet aggregation and blood vessel expansion. TXB 2 and 6-Keto-PGF 1α , which are mutually antagonistic, are the stable metabolites of TXA 2 and PGI 2 , respectively [34]. The dynamic balance of TXB 2 /6-Keto-PGF 1α is important for the regulation of vessel wall intensity and regional flow.…”

Section: Txb2 and 6-keto-pgf 1α In Serummentioning

confidence: 99%

Coagulant Effects and Mechanism of Schefflera heptaphylla (L.) Frodin

et al. 2019

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Schefflera heptaphylla (L.) Frodin, are commonly used in anti-inflammatory, analgesic, traumatic bleeding and hemostasisas. In this paper, the coagulation effect of the ethanol extract (Set), ethyl acetate phase (Sea) and n-butanol phase (Sbu) was evaluated by prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen content (FIB) assays in vitro. Then, Three main lupanine triterpenes (compounds A–C) were isolated and identified from Sea and Sbu by a bioassay-guided method and their structure were identified as 3α-Hydroxy-lup-20(29)-ene-23, 28-dioic acid, betulinic acid 3-O-sulfate and 3α-Hydroxy-lup-20(29)-ene-23, 28-dioic acid 28-O-(α-l-rhamnopyranosyl(1→4)-O-β-d-glucopyranosyl(1→6))-β-d-glucopyranoside) by spectroscopic data analysis. Among of them, compound B was confirmed to have significant coagulant effect in vitro. Furthermore, the pro-coagulation mechanism of S. heptaphylla extracts and compound B were investigated by measuring whole blood viscosity (WBV), plasma viscosity (PV), erythrocyte sedimentetion rate (ESR), pack cell volume (PCV), APTT, PT, TT, and FIB in vivo. Meanwhile, the levels of thromboxane B2 (TXB2), 6-keto prostaglandin F1α (6-keto-PGF1α), endothelial nitric oxide synthase (eNOS) and (endothelin-1) ET-1 were detected. The bleeding time (BT) was tested by tail bleeding method, which proved the traumatic bleeding and hemostasis activities of S. heptaphylla. The pharmacology experiments showed that the Set, Sea, Sbu and compound B has significant pro-coagulation effect. In addition, compound B might be the main constituent of pro-coagulation in S. heptaphylla These results could support the fact that S. heptaphylla could be used traditionally to cure traumatic bleeding, and the pro-coagulation effects were associated with the regulation of vascular endothelium active substance and hemorheology parameters.

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Antinociceptive and anti-inflammatory activities of Schefflera octophylla extracts

Cited by 25 publications

References 20 publications

Studies on analgesic, anti-inflammatory activities of stem and roots of Inula cuspidata C.B Clarke

Studies on analgesic, anti-inflammatory activities of stem and roots of Inula cuspidata C.B Clarke

Acankoreagenin and acankoreosides, a family of lupane triterpenoids with anti‐inflammatory properties: an overview

Coagulant Effects and Mechanism of Schefflera heptaphylla (L.) Frodin

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