Antinociceptive and Anti-inflammatory Activities of the Lectin from Marine Red Alga Solieria filiformis

Abstract

Lectins are proteins that bind to specific mono- or oligosaccharides. This study aimed to evaluate the antinociceptive and anti-inflammatory effects of the lectin from the red marine alga Solieria filiformis. The animals (n = 6) were pretreated with S. filiformis lectin 30 min before they were given the nociceptive or inflammatory stimulus. The antinociceptive activity was evaluated in Swiss mice using the abdominal writhing, formalin, and hot plate tests. The anti-inflammatory properties were evaluated in Wistar rats using carrageenan-induced peritonitis and paw edema induced by different phlogistic agents. The S. filiformis lectin toxicity was assayed through its application in mice (7 days). S. filiformis lectin significantly reduced the number of abdominal writhings and reduced the paw licking time in the second phase of the formalin test (p < 0.05), but it did not prolong the reaction time in the hot plate test (p > 0.05). Furthermore, S. filiformis lectin reduced neutrophil migration in a peritonitis model and reduced paw edema induced by carrageenan, dextran, and serotonin (p < 0.05). Additionally, the administration of S. filiformis lectin resulted in no signs of systemic damage. Thus, S. filiformis lectin appears to have important antinociceptive and anti-inflammatory activities and could represent a potential therapeutic agent for future studies.

Lectins from red algae and their biomedical potential

“…SfL and PcL lectins are effective in controlling inflammatory processes as they are not cytotoxic, promotes increased cell viability and induces Th2 immune response in mouse spleenocytes (Abreu et al 2012). Lectin from S. filiformis can also act as a therapeutic agent owing to its anti-nociceptive and anti-inflammatory potential (Abreu et al 2016). Anti-nociceptive and antiinflammatory activity of S. filiformis lectin was evaluated in Swiss mice and Wistar rats, respectively, which showed reduced number of abdominal writhings, reduced paw licking times and reduced neutrophil migration in a peritonitis model along with no signs of systemic damage (Abreu et al 2016).…”

Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care

“…The final highlight of the results in Table 2 should be given to a relevant number of studies that were condcted in vivo using mice and rats. Most of the reports described the reduction of paw oedema [115,121,126,141,157,[162][163][164][165][166][167] and reduced leukocyte influx/migration [168], or even both [116,[122][123][124][125]169,170], proving that red seaweed-derived compounds are effectively anti-inflammatory. Though a significant number of compounds isolated from Rhodophyta have proven to be anti-inflammatory, both in vitro and in vivo, the opportunity to investigate how these compounds behave in individuals suffering from AV remains open.…”

Research Progress in Anti-Inflammatory Bioactive Substances Derived from Marine Microorganisms, Sponges, Algae, and Corals

“…Marine lectins are glycoproteins or peptides that bind to specific mono or oligosaccharides, which can promote cell recognition and adhesion, and some of them also showed strong anti-inflammatory activity. A lectin from the red marine alga Solieria filiformis reduced neutrophil migration in a peritonitis model and decreased paw edema induced by carrageenan, dextran, and serotonin with no signs of systemic damage in mice [ 67 ]. The anti-inflammatory mechanism of a lectin from the green seaweed Caulerpa cupressoides var.…”