Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care

Abstract

Acne vulgaris (AV) is a chronic skin disease of the pilosebaceous unit affecting both adolescents and adults. Its pathophysiology includes processes of inflammation, increased keratinization, sebum production, hormonal dysregulation, and bacterial Cutibacterium acnes proliferation. Common AV has been treated with antibiotics since the 1960s, but strain resistance has emerged and is of paramount concern. Macroalgae are known producers of substances with bioactive properties, including anti-viral, antibacterial, antioxidant, and anti-inflammatory properties, among several others. In particular, red algae are rich in bioactive compounds such as polysaccharides, phenolic compounds, lipids, sterols, alkaloids, and terpenoids, conferring them antioxidant, antimicrobial, and anti-inflammatory activities, among others. Thus, the exploration of compounds from marine resources can be an appealing approach to discover new treatment options against AV. The aim of this work is to provide an overview of the current knowledge of the potentialities of red macroalgae in the treatment of AV by reviewing the main therapeutic targets of this disease, and then the existence of compounds or extracts with bioactive properties against them.

In-Vivo Pharmacological Studies of Hypnea Musciformis Found in the Coast of Saint Martin Island of Bangladesh

“…According to the approach described by Januário et al, the analgesic efficacy of Hypnea musciformis extract was assessed (Januário et al, 2021). Three groups of mice, each with four mice, were selected at random.…”

Marine natural products

“…402,403 A review of new Laurencia -derived sesquiterpenoids from 2015–2020 has been published, 404 as has a review of red algal compounds with potential as anti-acne treatments. 405 A review of developments in synthetic methodology to produce the important neuromodulatory compound kainic acid was also published. 406 Two separate reports have identified anti-angiogenesis activity for red algal compounds.…”

Efficacy of alpha hydroxy acid combined with intense pulsed light in the treatment of acne vulgaris: A meta‐analysis

“…There were several limitations to the study: (1) The included studies' limited sample sizes, the fact that the literature is all in Chinese and covers a small area. Most of the studies that met the outcome indicators were conducted on Asian populations, and the geographical differences that may affect the accuracy and reliability of the results.…”

“…It often occurs in adolescents and is characterized by acne, papules, pustules, nodules, cysts, and mainly affects the face, chest, and back. Many factors contribute to the development of acne, most notably the overproduction of androgens, which leads to high sebum production, hyperkeratosis of the hair follicles, and the proliferation of Propionibacterium acnes, causing an inflammatory response in the skin 1 . Currently, there are many clinical treatments for acne, mainly based on traditional medications such as benzoyl peroxide, retinoids, and antibiotics, but with some limitations such as long treatment times, risk of drug resistance, and intolerable side effects for patients 2,3 …”

“…skin. 1 Currently, there are many clinical treatments for acne, mainly based on traditional medications such as benzoyl peroxide, retinoids, and antibiotics, but with some limitations such as long treatment times, risk of drug resistance, and intolerable side effects for patients. 2,3 Studies have shown that IPL (Intense Pulsed Light) has excellent bactericidal and anti-inflammatory effects on Propionibacterium acnes, improves global acne-grading system (GAGS) levels in acne vulgaris, and inhibits sebum production.…”