Antinociceptive and anti-inflammatory effects of the aerial parts ofArtemisia dracunculusin mice

Abstract

Context: Tarragon (Artemisia dracunculus L., Asteraceae) is an ancient herb, which is widely used as a medicine, flavoring, or fragrance. Objective: To determine the antinociceptive and anti-inflammatory effects of aerial parts of tarragon, we investigated the effects of ethanolic extract of the plant in adult male Balb/c mice. Materials and methods: Antinociceptive activity was determined using formalin, hot-plate, and writhing tests. The effect of the ethanolic extract on acute inflammation was evaluated by xylene-induced ear edema in mice. The ethanolic extract was administered at doses of 5, 10, 50, and 100 mg/kg, i.p. The control group received saline as vehicle of ethanolic extract. Results: Our results showed that the ethanolic extract (50 and 100 mg/kg) decreased both phases of pain in the formalin test (ED 50 ¼ 109.66 and 87.13 mg/kg, respectively). In the hot-plate test, the extract (50 and 100 mg/kg) increased pain threshold during 60 min (ED 50 ¼ 81.03 mg/kg). The extract (50 and 100 mg/kg) exhibited antinociceptive activity against acetic acid-induced writhing (ED 50 ¼ 66.99 mg/kg). The extract (50 and 100 mg/kg) showed significant activity in the xylene ear edema test (ED 50 ¼ 78.20 mg/kg). Pretreatment of the animals with naloxone decreased the analgesia induced by the extract in hot-plate and formalin tests; therefore, opioid receptors may be involved, at least partly, in the analgesic effect of tarragon extract. Discussion and conclusion: The results suggested that tarragon have significant analgesic and anti-inflammatory effects in mice, and, therefore, further studies are required to evaluate these effects and additional potential of the plant.

An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes

“…PMI-5011 treatment also led to an inhibition of cytokine-induced activation of inflammatory signaling pathways (Vandanmagsar et al, 2014). Anti-inflammatory effect of ethanol extract was also demonstrated in murine model (Eidi et al, 2016). These data indicate that this PMI-5011 A. dracunculus L. extract represents a promising botanical treatment for patients with diabetes.…”

Effects of tarragon (Artemisia dracunculus) powder on broiler performance parameters and histopathology of internal organs

“…In addition, tarragon has unique biological activity and phytochemicals (Daly et al 2010, Obolskiy et al 2011, Tak et al 2014, Kumlay et al 2015. Tarragon is known to have antibacterial, antifungal, and antitumor properties and has been used in antidiarrheal, analgesic and anti-inflammatory treatments (Obolskiy et al 2011, Meepagala et al 2002a , Lopes-Lutz et al 2008, Jalilzadeh-Amin and Qarehdarvishlu 2014, Eidi et al 2015. For example, due to its level of terpene, tarragon has been used to treat gastrointestinal complaints, such as diarrhoea (Kumlay et al 2015, Jalilzadeh-Amin andMaham 2015).…”

Analgesic, anti-inflammatory and anti-pyretic activities of methanolic extract of Cordyline fruticosa (L.) A. Chev. Leaves

“…Non-steroidal anti-inflammatory drugs (NSAIDs) act by inhibiting PGE2 synthesis. When NSAIDs are used for treating inflammation, pain and fever, then they may show several side effects [7][8]. Gastrointestinal ulceration, fluid retention, bronchospasm, and prolongation of bleeding time are common side effect of NSAIDs, while opioids develop addiction and dependency as a side effect during the clinical use of these drugs [2,9].…”

“…Gastrointestinal ulceration, fluid retention, bronchospasm, and prolongation of bleeding time are common side effect of NSAIDs, while opioids develop addiction and dependency as a side effect during the clinical use of these drugs [2,9]. Therefore, searching of agents with better safety and efficacy profile can overcome the limitation of commonly prescribed NSAID drugs [8]. Under such circumstances, traditional medicinal plants can be a dependable source for the management of various diseases [10].…”