Antinociceptive and Anti-Inflammatory Properties of Daucus carota Seeds Extract

Abstract

The ethanolic extract of Daucus carota seeds (DCE) was investigated for anti-inflammatory and analgesic activity at the doses [per oral (p.o.)] of 100, 200 and 400 mg/kg body weight. For evaluation of inflammation carrageenan-, histamine-and serotonin-induced paw edema served as acute models and formaldehyde-induced arthritis served as a chronic model in rats. The acetic acid-induced writhing response and formalin-induced paw licking time in the early and late phases of mice were used to assess analgesic activity. The higher doses of DCE (200 and 400 mg/kg, p.o.) were inhibiting carrageenan, histamine and serotonin-induced paw edema as well as formaldehyde-induced arthritis successfully. In addition, DCE (200 and 400 mg/kg, p.o.) significantly attenuated the writhing responses induced by an intraperitoneal injection of acetic acid and late phase of pain response induced by an subplantar injection of formalin in mice.

Chemical Composition and Anti-inflammatory Activity of Algerian Thymus vulgaris Essential Oil

“…30 min after drug administration; edema was induced by injecting 50 µL carrageenan (1%, w/v) into the sub-plantar region of the right hind paw. Paw thickness (mm) was measured using digital vernier calipers before injection and every 60 min for 6 h after induction of the inflammation [31]. Edema inhibition percentage was calculated as follows:…”

Anti-inflammatory effect of Algerian date fruit (Phoenix dactylifera)

“…However, studies have been continuing on inflammatory disease and the side effects of the currently available anti-inflammatory drugs pose a major problem during their clinical use. Therefore, development of newer and more anti-inflammatory drugs with lesser side effects is necessary (Vasudevan, Gunnam, & Parle, 2006). …”

Antinociceptive and anti-inflammatory effects of the ethanol extract ofAlpinia conchigerarhizomes in various animal models

“…Peripheral COX involvement is suggested based on the ability of ACRE to inhibit the writhing response (Deraedt et al, 1980;Berkenkopf & Weichman, 1988) and carrageenan-induced paw edema (Gamache et al, 1986). The writhing test has been associated with an increase of prostanoids (prostagalndins PGE 2 and PGF 2α ) released in peritoneal fluids as well as other lipooxygenase (LO) products (Vasudevan et al, 2006;Choi et al, 2006), while carrageenan-induced inflammation is more effectively controlled with the arachidonate COX, but not arachidonate LO, inhibitors (Gamache et al, 1986). The involvement of central COX in pain response has been reported by Pini et al (1997).…”

“…The development of edema in the paw of the rat after the administration of carrageenan is characterized by a biphasic process. The initial phase observed during the first hour is attributed to the release of histamine and serotonin, while the second phase of edema is due to the release of prostaglandins (Crunkhorn & Meacock, 1971;Vasudevan et al, 2006). Salvemini et al (1996), on the other hand, described the late phase as being the result of neutrophil infiltration as well as the continuous production of arachidonic metabolites.…”