Antinociceptive and antiinflammatory activities and QSAR studies on 2-substituted-4,5-diphenyl-1H-imidazoles

Synthesis and Antimicrobial Evaluation of Some New Thiazolo Imidazole Analogs

“…Imidazoles are more vital in many biological processes since they are present in many natural compounds. Many synthetic pyrimidine analogs are also known to exhibit a variety of therapeutic uses including antiviral [9], antimycobacterial [10], antitumor [11], anti-inflammatory [12], antidepressant [13], branchodilatory [14], antifungal activity [15], etc.…”

Nano Copper Ferrite Catalyzed Sonochemical, One-Pot Three and Four Component Synthesis of Poly Substituted Imidazoles

“…Because of their wide range of pharmacological importance and significant role in biochemical processes [3] [4], the Biological importance of the poly substituted imidazole ring system has made it a common structure in numerous synthetic compounds, such as fungicides [5], herbicides [5], therapeutic agents [6] and plant-growth regulators [7]. This core also has been utilized in diverse pharmaceutical applications such as anti-inflammatory [8], anti-thrombotic [9] and antitumor [10] agents.…”

“…Later on a first, simple and convenient synthetic methodology has been reported by Radziszewski and japp for the synthesis of 2,4,5-tri phenyl imidazoles by using 1,2 dicarbonyl compounds, ammonia, various aldehydes [14]. Afterward several methods have been reported for the synthesis of tri-substituted imidazoles by cyclo condensation of 1,2 dicarbonyl compounds, various aromatic aldehydes and ammonium acetate using various catalysts such as NiCl 2 •6H 2 O/Al 2 O 3 [15], MoO 3 /SiO 2 [16], Polymer supported zinc chloride [17], trichloro isocyanuric acid (TCCA) [18] under reflux conditions and glyoxalic acid as catalyst under microwave conditions [19] and Zinc (II) (tetra (4-methylphenyl)) porphyrin [20], Magnetic Fe 3 O 4 nano particles [21], Sulfamic acid functionalized magnetic nano particles SA-MNP [22], Ionic liquid (EMIM)OAc [23], Zr(acac) 4 [24], ceric ammonium nitrate [25] as catalysts under ultra sound assisted conditions. In the same way several methods have been reported for the synthesis of tetra substituted imidazoles by cyclo condensation of 1,2 dicarbonyl compounds, various aromatic aldehydes, ammonium acetate and aromatic/aliphatic amines using various catalysts such as nano TiCl 4 •SiO 2 [26] [33] as catalyst under Ultra sound irradiation.…”

“…Afterward several methods have been reported for the synthesis of tri-substituted imidazoles by cyclo condensation of 1,2 dicarbonyl compounds, various aromatic aldehydes and ammonium acetate using various catalysts such as NiCl 2 •6H 2 O/Al 2 O 3 [15], MoO 3 /SiO 2 [16], Polymer supported zinc chloride [17], trichloro isocyanuric acid (TCCA) [18] under reflux conditions and glyoxalic acid as catalyst under microwave conditions [19] and Zinc (II) (tetra (4-methylphenyl)) porphyrin [20], Magnetic Fe 3 O 4 nano particles [21], Sulfamic acid functionalized magnetic nano particles SA-MNP [22], Ionic liquid (EMIM)OAc [23], Zr(acac) 4 [24], ceric ammonium nitrate [25] as catalysts under ultra sound assisted conditions. In the same way several methods have been reported for the synthesis of tetra substituted imidazoles by cyclo condensation of 1,2 dicarbonyl compounds, various aromatic aldehydes, ammonium acetate and aromatic/aliphatic amines using various catalysts such as nano TiCl 4 •SiO 2 [26] [33] as catalyst under Ultra sound irradiation. In extension with these procedures, several methods have been reported for the synthesis of both tri and tetra substituted imidazoels using various catalysts such as molecular Iodine [34], Sodium dihydrogen phosphate [35], BiCl 3 [36], DABCO [37] According to the literature survey, several synthetic protocols have been reported for the synthesis of substituted imidazoles using various type of copper containing catalyst such as synthesis of imidazoles through the Cu 2 O catalyzed cross-cycloaddition between two different isocyanides [43], Synthesis of 1,2,4-trisubstituted imidazoles through the CuCl 2 -catalyzed oxidative diamination of terminal alkynes by amidines [44], Synthesis of multi substituted imidazoles via CuI-catalyzed [3 + 2] cycloadditions [45].…”

DFT Study on 4(5)-Imidazole-carbaldehyde-N(5)-phenylthiosemicarbazone (ImTPh): NMR Shielding Tensors, Thermodynamic Parameters, NBO Analysis, Molecular Electrostatic Potential (MEP), HOMO and LUMO Studies

“…such as antifungal and anti-bacterial activity 1 , anti inflammatory activity and analgesic activity 2 , antitubercular activity 3 , anti depressant activity, anti cancer activity 4 , antiviral activity 5 and antileishmanial activity. Due to their antifungal properties imidazolederived compounds have been used in agriculture as effective ingredients for controlling plants pests.…”