Antinociceptive, anti-inflammatory and wound healing features in animal models treated with a semisolid herbal medicine based on Aleurites moluccana L. Willd. Euforbiaceae standardized leaf extract

Cesca, Talita Gesser; Faqueti, Larissa; Rocha, Lilian W.; Meira, Nicole Anzanelo; Meyre‐Silva, Christiane; Souza, Márcia María de; Quintão, Nara Lins Meira; Silva, R.M.L.; Filho, Valdir Cechinel; Bresolin, Tania Mari Bellé

doi:10.1016/j.jep.2012.06.051

Cited by 33 publications

(20 citation statements)

References 38 publications

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“…In fact, the resultsobtained shown that after croton oil administration in animals pretreated with A. moluccana extract the neutrophil migration was significantly reduced (41.50±9.30%, Figure 3). Quintão et al (2012) have also demonstrated that the treatment with A. moluccanadried extract, using oral administration route, was capable of drastically reducing the neutrophil migration induced by intraplantar injection of carrageenan. As mentioned before, the neutrophil migration depends on the production and release of chemokines.…”

Section: Resultsmentioning

confidence: 88%

“…The animals pre-treated with the semisolid containing the plant extract or dexamethasone, the drug used as positive control, was able to significantly reduce the edema with inhibition values of 35.77±7.35% and 97.69±2.30%, respectively. Cesca et al (2012) have demonstrated that a semisolid of A. moluccana (1%) significantly prevented the ear thickness increase (64.80±6.20%) when compared with the vehicle. It is important to mention that the semisolid composition previously used by the author was different, what could justify the difference between the achived inhibitions.…”

Section: Resultsmentioning

confidence: 92%

“…The effect promoted by extract was mediated by inhibiting the neutrophil migration and IL-1β release after carrageenan and CFAinduced mechanical nociception (Cechinel-Filho, 2000;Quintão et al 2012;2014).…”

Section: Resultsmentioning

confidence: 99%

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Topical anti-inflammatory activity of semisolid containing standardized Aleurites moluccana L. Willd (Euphorbiaceae) leaves extract

Hoepers

Souza

Quintão

et al. 2015

Journal of Ethnopharmacology

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This study demonstrated for the first time the mechanisms involved in the topical anti-inflammatory effect presented by the semisolid containing A. moluccana dried extract pointing as the main mechanism is the reduction in the leukocyte migration and consequently resulting in diminished levels of cytokins and chemokines, indicating this herbal product as a promissor anti-inflammatory phytomedicine to treat skin inflammatory diseases.

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Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 92%

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Topical anti-inflammatory activity of semisolid containing standardized Aleurites moluccana L. Willd (Euphorbiaceae) leaves extract

Hoepers

Souza

Quintão

et al. 2015

Journal of Ethnopharmacology

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“…Medicinal plants have been identified as a safe and effective alternative for the treatment of dermatological inflammatory diseases, replacing conventional drugs such as corticosteroids and nonsteroidal anti-inflammatory drugs (Bralley et al 2008;Maldini et al 2009;Cesca et al 2012). In this study, we identified polar compounds in S. trilobata hydroethanolic extract and also developed a new topical phytomedicine based on KA content with significant anti-inflammatory effects.…”

Section: Discussionmentioning

confidence: 99%

Topical anti-inflammatory phytomedicine based onSphagneticola trilobatadried extracts

Fucina¹,

Rocha²,

Silva³

et al. 2016

Pharmaceutical Biology

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Context: The aerial parts of Sphagneticola trilobata (L.) Pruski (Asteraceae) are popularly used to treat topical inflammation, but have not been fully investigated. Objective: To identify polar compounds in S. trilobata extracts and develop a new topical phytomedicine based on the kaurenoic acid (KA) content while monitoring and demonstrating its topical anti-inflammatory activity. Materials and methods: Ethanol spray-dried extract of S. trilobata was analysed by LC-MS while the KA content from semisolid was analysed by LC-UV. The extent of ear edema induced by applying 20 lL of croton oil (2.5%), arachidonic acid (AA; 2 mg/ear) and decanoylphorbol-13-acetate (TPA; 2.5 mg/ear) in mice was used to evaluate the biological activity of the semisolids, which were applied 30 min before the phlogistic agents. Results: Eight phenylpropanoids and four oleanane-type triterpenoid saponins were identified, majority of them reported for the first time in this species, in addition to KA. The semisolid containing 1.0% of dried extract reduced the ear edema induced by croton oil [77.2 6 4.5%; ID50 ¼ 0.49 (0.28-0.87%)], TPA (81.5 6 2.4%) and AA (39.1 6 6.9%), with decreasing effect at higher KA concentrations. This was accompanied by neutrophil migration inhibition as investigated by biochemical and histological assays. Discussion and conclusion: The anti-inflammatory effects were (at least in part) due to the interference in protein kinase C (PKC) activation, AA-cascade products and neutrophil migration inhibition, demonstrating the efficacy of the folk topical usage of this plant. The results support the development of a novel topical anti-inflammatory phytomedicine properly standardized to treat inflammatory dermatological diseases. ARTICLE HISTORY

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“…A. mollucanna has also been found to possess antiviral [33] and antimicrobial properties [34] demonstrating how the presence of multiple active compounds in plant extracts can have several benefits to patients. Due to this historical link between A. mullucanna and anti-nociceptive and antiinflammatory therapies, A. mullucanna extracts have been used to produce analgesic and anti-inflammatory phytomedicines [35,36]. The major focus of this work was on the wound healing effects of A. mollucanna extracts, although the use of this plant in traditional remedies for asthma suggests that there is a possibility for the active compounds of A. mullucanna to be adapted to produce a phytomedicine for asthma and its related symptoms.…”

Section: Plant-derived Therapies For Asthmamentioning

confidence: 99%

Herbal treatment in asthma and COPD – current evidence

2015

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Asthma and COPD are chronic inflammatory respiratory diseases affecting millions of people worldwide and increasing in prevalence. Current treatment options for both conditions aim to alleviate symptoms, improve patient quality of life and prevent disease progression rather than cure the underlying condition itself. Treatments available to patients include anti-inflammatory therapies, bronchodilators and inhaled corticosteroids. While these treatments have been deemed effective at alleviating disease symptoms and exacerbations they are not without their limitations. Overuse of some therapies can induce adverse effects in some patients such as increased risk of developing pneumonia and cardiac co-morbidities. Along with the risks of side effects not all patients will respond to the current treatment options and therefore there is an unmet need for additional or alternative treatments for asthma and COPD. One such area showing good promise in providing an alternative or add-on therapy is that of phytomedicine. Phytomedicine is defined as a plant-based traditional medical practice that uses various plant materials in modalities considered both preventive and therapeutic. This review focuses on recent human clinical trials using plant-based medicines for the treatment of asthma and COPD.

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Antinociceptive, anti-inflammatory and wound healing features in animal models treated with a semisolid herbal medicine based on Aleurites moluccana L. Willd. Euforbiaceae standardized leaf extract

Cited by 33 publications

References 38 publications

Topical anti-inflammatory activity of semisolid containing standardized Aleurites moluccana L. Willd (Euphorbiaceae) leaves extract

Topical anti-inflammatory activity of semisolid containing standardized Aleurites moluccana L. Willd (Euphorbiaceae) leaves extract

Topical anti-inflammatory phytomedicine based onSphagneticola trilobatadried extracts

Herbal treatment in asthma and COPD – current evidence

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