Antinociceptive effect of 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole. A Celecoxib structural analog in models of pathological pain

Oliveira, Sara Marchesan; Silva, Cássia Regina; Wentz, Alexandre P.; Paim, Gisele R.; Correa, Michele S.; Bonacorso, Hélio G.; Prudente, Arthur Silveira; Otuki, Michel Fleith; Ferreira, Juliano

doi:10.1016/j.pbb.2014.07.005

Cited by 46 publications

(18 citation statements)

References 72 publications

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“…Therefore, the use of an intact organism was important to obtain an adequate response to the experimental models used here. In this context, Swiss mice have been used previously in experiments involving postoperative pain (Oliveira et al, ; ), partial sciatic nerve ligation‐induced neuropathic pain (Villarinho et al, ; Oliveira et al, ) and paclitaxel ‐induced neuropathic pain (Brusco et al, ).…”

Section: Methodsmentioning

confidence: 99%

α‐Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice

Brusco

Camponogara

Carvalho

et al. 2017

British J Pharmacology

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Section: Methodsmentioning

confidence: 99%

α‐Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice

Brusco

Camponogara

Carvalho

et al. 2017

British J Pharmacology

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“…MPO activity was determined using an assay described previously [11, 12]. After six hours of application of croton oil, the MPO enzyme activity was assessed in the ear samples.…”

Section: Methodsmentioning

confidence: 99%

Solanum paranense Extracts and Solanine Present Anti‐Inflammatory Activity in an Acute Skin Inflammation Model in Mice

Piana

Camponogara

Boligon

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The aim of the study was to evaluate the anti-inflammatory activity of the S. paranense crude extract, S. paranense alkaloid fraction, and solanine alkaloid. These samples reduce the croton oil-induced ear edema in a dose-dependent manner and a maximum inhibition of 81%, 98%, and 80% in the doses of 1.0, 0.73, and 0.37 mg/ear, respectively. Moreover, the samples inhibit the MPO activity with an inhibition maximum of 51%, 40%, and 46% in the doses of 1.0, 0.73, and 0.37 mg/ear, respectively. Similar results were found for dexamethasone 0.10 mg/ear (positive control), which showed inhibitions of ear edema and MPO activity of 100% and 65%, respectively. These results found probably are related to the presence of solanine which is present in significant quantity in the alkaloid fraction and others as rutin and rosmarinic, chlorogenic, and gallic acids. These results support the use of S. paranense for the treatment of inflammatory skin disorders.

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“…Locomotor activity. The impulsive motor activity was evaluated using SK-25 with actophotometer [35]. Each mouse was placed in a square bunged field arena (30 cm × 30 cm × 30 cm) fitted with six photocells before and after administration of test compounds for 5 min.…”

Section: Assessment Of Adverse Effectsmentioning

confidence: 99%

Antitumour and Acute Toxicity Studies of 4-(pyridin-4-yl)-6-(thiophen-2-yl)pyrimidin-2(1<em>H</em>)-one Against Ehrlich Ascites Carcinoma and Sarcoma-180

Kumar¹,

Sharma²,

Nepali³

et al. 2018

Preprint

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In an effort to discover an effective and selective antitumour agent, synthesis and anti-cancer potential of 4-(pyridin-4-yl)-6-(thiophen-2-yl)pyrimidin-2(1H)-one (SK-25), which has been reported earlier by us with significant cytotoxicity towards MiaPaCa-2 malignant cells, with an IC 50 value of 1.95 μM and was found to instigate apoptosis. In the present study, the antitumour efficacy of SK-25 was investigated on Ehrlich ascites tumour (solid), Sarcoma 180

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Antinociceptive effect of 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole. A Celecoxib structural analog in models of pathological pain

Cited by 46 publications

References 72 publications

α‐Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice

α‐Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice

Solanum paranense Extracts and Solanine Present Anti‐Inflammatory Activity in an Acute Skin Inflammation Model in Mice

Antitumour and Acute Toxicity Studies of 4-(pyridin-4-yl)-6-(thiophen-2-yl)pyrimidin-2(1<em>H</em>)-one Against Ehrlich Ascites Carcinoma and Sarcoma-180

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