Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model in rats

Abstract

Neuropathic pain is a chronic neurodegenerative disease. It is well characterized by spontaneous pain, hyperalgesia, hypothesia, dysesthesia and allodynia. The present study was designed to investigate the antinociceptive potential of Butea monosperma on vincristine-induced painful neuropathy in rats. Vincristine was administered for induction of neuropathic pain in experimental animals. Hot plate, acetone drop, paw pressure, Von Frey hair and tail immersion tests were performed to assess the degree of thermal hyperalgesia, cold chemical allodynia, mechanical hyperalgesia and allodynia in the hind paw and tail thermal hyperalgesia, respectively, as an index of peripheral and central pain sensation. Tissue thiobarbituric acid reactive substances (TBARSs), reduced glutathione (GSH) and total calcium levels were estimated to assess the biochemical changes in the sciatic nerve tissue. Microscopically, histopathological changes were also observed in the sciatic nerve tissue. Ethanolic extract of B. monosperma leaves and pregabalin were administered for 14 consecutive days. Vincristine administration resulted in significant reduction in behavioural (i.e. hyperalgesia and allodynic pain sensation) changes along with a rise in the levels of TBARS, total calcium and decrease in GSH levels when compared with the normal control group. Moreover, significant histological changes were also observed. Pretreatment with B. monosperma significantly attenuated vincristine-induced development of painful behavioural, biochemical and histological changes in a dose-dependent manner, which is similar to that of pregabalin-pretreated group. B. monosperma ameliorated vincristine-induced painful neuropathy. It may be due to its potential of antioxidative, neuroprotective and calcium channel inactivation.

The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model

“…21,22 Concentrations of thiobarbituric acid reactive substances (TBARS) and superoxide anions were increased by vincristine treatment. 23,24 It has been reported that lipoic acid treatment reversed indices of oxidative stress, Table 1. Effect of intraperitoneal injection with normal saline or thioctic acid on mechanical allodynia withdrawal threshold in vincristine-induced neuropathy in a rat model.…”

Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy

“…Oral intake of ethanolic extract of B. monosperma (200-400 mg/kg for 14 days) suppressed histological, biochemical, and behavioral changes induced by vincristine in rats. Authors have suggested that the therapeutic benefits might originate from its calcium channel inactivating, anti-oxidative, anti-inflammatory, and neuroprotective effects [29].…”

Essential and Non-Essential Elemental Composition of Five Different Major Parts of Butea monosperma (Palash) by Inductively Coupled Plasma-Optical Emission Spectrometer (ICP-OES)

“…An imbalance in the diet can lead to malnutrition; eating low amounts of certain nutrients can lead to deficiencies while eating too much can lead to toxicities. The elemental distribution in BM was compared to Dietary Reference Intakes (DRIs) (TABLE [5][6][7][8][9][10][11]. If an average serving size of 10 g (dry mass) of BM is consumed it would contribute significantly towards the daily intake of important nutrients.…”

“…The plant has proven efficacy for antioxidant [5] anti-obesity [6] anticancer, and chemoprotective [7] potential. It is also useful against neuropathic [8] and peripheral pain.…”