Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid

Nascimento, Marcus Vinícius Mariano; Galdino, Pablinny Moreira; Florentino, Iziara Ferreira; Sampaio, Bruno Leite; Vanderlinde, Frederico Argollo; Paula, José Realino de; Costa, Élson Alves

doi:10.1007/s11418-011-0517-y

Cited by 19 publications

(15 citation statements)

References 37 publications

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“…In fact, the broad community access to Amazon or Pantanal biome, and the close relationship with the indigenous native populations, promotes a variety of possibilities of ethnobotanical indications. Examples of other popular uses of L. pacari that have been experimentally confirmed includes weight loss [145], anorectic effect [142], antipyretic activity [146], anti-inflammatory [147], antiallergic [148], and analgesic property [149]. …”

Section: Discussionmentioning

confidence: 99%

Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)

Bieski

Rios-Santos

Oliveira

et al. 2012

Evidence-Based Complementary and Alternative Medicine

143

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Traditional knowledge is an important source of obtaining new phytotherapeutic agents. Ethnobotanical survey of medicinal plants was conducted in Nossa Senhora Aparecida do Chumbo District (NSACD), located in Poconé, Mato Grosso, Brazil using semi-structured questionnaires and interviews. 376 species of medicinal plants belonging to 285 genera and 102 families were cited. Fabaceae (10.2%), Asteraceae (7.82%) and Lamaceae (4.89%) families are of greater importance. Species with the greater relative importance were Himatanthus obovatus (1.87), Hibiscus sabdariffa (1.87), Solidago microglossa (1.80), Strychnos pseudoquina (1.73) and Dorstenia brasiliensis, Scoparia dulcis L., and Luehea divaricata (1.50). The informant consensus factor (ICF) ranged from 0.13 to 0.78 encompassing 18 disease categories,of which 15 had ICF greater than 0.50, with a predominance of disease categories related to injuries, poisoning and certain other consequences of external causes (ICF = 0.78) having 65 species cited while 20 species were cited for mental and behavioral disorders (ICF = 0.77). The results show that knowledge about medicinal plants is evenly distributed among the population of NSACD. This population possesses medicinal plants for most disease categories, with the highest concordance for prenatal, mental/behavioral and respiratory problems.

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Section: Discussionmentioning

confidence: 99%

Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)

Bieski

Rios-Santos

Oliveira

et al. 2012

Evidence-Based Complementary and Alternative Medicine

143

View full text Add to dashboard Cite

show abstract

“…On the other hand, the high dose bufalin (0.6 mg/kg) inhibited both phases of the formalin test, but its effect was more pronounced in the inflammatory phase. This result suggested that a high dose of bufalin also modulates acute neurogenic pain, which is sensitive to drugs with a central action [26, 27, 30]. …”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents

Wen

Huang

Xie

et al. 2014

Mediators of Inflammation

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The aims of this study were to evaluate the anti-inflammatory and analgesic effects of bufalin, a major component of “Chan-su.” We used a carrageenan-induced paw edema model to assess the anti-inflammatory activity of this compound, and Western blot analysis detected NF-κB signaling during this effect. The antinociceptive activities were evaluated by acetic acid-induced writhing, formalin, and hot-plate tests; open-field test investigated effects on the central nervous system. Our data showed that bufalin (0.3 and 0.6 mg/kg, i.p.) potently decreased carrageenan-induced paw edema. Bufalin down regulated the expression levels of nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) during these treatments. Further studies demonstrated that bufalin significantly inhibited the activation of NF-κB signaling. Bufalin also reduced acetic acid-induced writhing and the licking time in the formalin test and increased hot-plate reaction latencies. Naloxone pretreatment (2 mg/kg, i.p.) in the early phases of the formalin test and hot-plate test significantly attenuated the bufalin-induced antinociception effects, which suggests the involvement of the opioid system. A reduction in locomotion was not observed in the open-field test after bufalin administration. Taken together, bufalin treatment resulted in in vivo anti-inflammatory and analgesic effects, and bufalin may be a novel, potential drug for the treatment of inflammatory diseases.

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“…EA has been reported to be effective as an antinociceptive compound in several nociceptive assays. [111221] Moreover, in our previous work, we demonstrated the participation of both central and peripheral antinociception induced by EA in several pain models, which was mediated through opioidergic and NO-cGMP pathways. [13]…”

Section: Discussionmentioning

confidence: 99%

“…[11] Moreover, Corbett et al ., (2010) showed that EA decreases paw edema induced by 3% carrageenan and may interact with ketorolac as a potent inhibitor of COX enzyme. [12] In a previous study, we demonstrated that EA produces antinociceptive effects in different experimental models of nociception via the opioidergic and NO-cGMP pathways in different animal models of pain.…”

Section: Introductionmentioning

confidence: 99%

Sildenafil enhances the peripheral antinociceptive effect of ellagic acid in the rat formalin test

2014

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Objective:Ellagic acid (EA), a major polyphenolic compound of pomegranate juice, produces antinociceptive effects, which are mediated through opioidergic and nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathways. The present study was conducted to elucidate the peripheral antinociceptive effect of EA alone and in combination with sildenafil in the rat formalin test.Materials and Methods:Pain was produced by intraplantar injection of formalin (2.5%) in rats and nociceptive behavior was measured as the number of flinches every 5 min in 60 min after injection.Results:Local administration of EA and sildenafil dose-dependently increased the nociception threshold in both phases of the test. Moreover, sub-effective doses of sildenafil (25 or 50 mcg/paw, i.p.) significantly and dose-dependently enhanced the antinociception induced by a sub-effective dose of EA (60 mcg/paw, i.pl.) in both phases of the test. The antinociception produced by these drugs alone, or in combination, was due to a peripheral site of action, since the administration in the contralateral paw was ineffective.Conclusion:Our results suggest that EA has local peripheral antinociceptive activity, and enhancement of this effect with sildenafil probably occurs through the inhibition of cGMP metabolism.

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Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid

Cited by 19 publications

References 37 publications

Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)

Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)

Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents

Sildenafil enhances the peripheral antinociceptive effect of ellagic acid in the rat formalin test

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