Antinociceptive effect of methanol extract of<i>Capparis ovata</i>in mice

Arslan, Rana; Bektaş, Nurcan

doi:10.3109/13880201003629323

Cited by 33 publications

(10 citation statements)

References 25 publications

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“…Both tail immersion and hot plate test measure the latency time of mice to thermal stimuli. Tail immersion monitors a spinal reflex involving μ 2 - and δ-opioid receptors, whereas the hot plate demonstrates supraspinal reflex mediated by μ 1 - and μ 2 -opioid receptors [29]. Therefore, the results of the present study indicate that the central antinociceptive effect of C. rotundus may be prominent on μ-opioid receptors.…”

Section: Resultsmentioning

confidence: 64%

Evaluation of antinociceptive activity of hydromethanol extract of Cyperus rotundus in mice

Imam

Sumi

2014

BMC Complement Altern Med

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BackgroundCyperus rotundus Linn. (Cyperaceae) is used to treat inflammation, pain, fever, wounds, boils and blisters in folk medicine. This study evaluated the antinociceptive effect of the hydromethanol extract of whole plant of C. rotundus (HMCR).MethodsThe antinociceptive activity of HMCR was investigated in thermal-induced (hot plate and tail immersion) and chemical-induced (formalin) nociception models in mice at three different doses (50, 100 and 200 mg/kg; p.o.). Morphine sulphate (5 mg/kg, i.p.) and diclofenac sodium (10 mg/kg, i.p.) were used as reference analgesic agents.ResultsIn the hot-plate and tail-immersion tests HMCR significantly increased the latency period to the thermal stimuli at all the tested doses (50, 100 and 200 mg/kg) (p < 0.05). The significant increase in latency is clear from the observations at 60 and 90 min. In formalin-induced paw licking test oral administration of HMCR at 100 and 200 mg/kg doses decreased the licking of paw in early phase. All the tested doses (50, 100 and 200 mg/kg) significantly decreased the licking of paw in late phase of the test (p < 0.001). The dose 200 mg/kg was most effective showing maximum percentage of inhibition of licking in both early (61.60%) and late phase (87.41%).ConclusionThese results indicate the antinociceptive effect of C. rotundus and suggest that this effect is mediated by both peripheral and central mechanisms. These results support the traditional use of this plant in different painful conditions.

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Section: Resultsmentioning

confidence: 64%

Evaluation of antinociceptive activity of hydromethanol extract of Cyperus rotundus in mice

Imam

Sumi

2014

BMC Complement Altern Med

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“…The central antinociceptive effect of MEDS may arise through opioid receptors of spinal as well as a supraspinal system. Both tail immersion and hot plate tests are based on measuring the response of the animal to thermal stimuli where the tail immersion check a spinal reflex, and the hot plate is used for supraspinal reflex [48]. Reach an agreement with this suggestion that μ2- and δ-opioid receptors are involved in spinal mechanism, while μ1/μ2-opioid receptors may mediate principally supraspinal analgesia [49].…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice

Mannan

Khatun

Khan

2017

BMC Complement Altern Med

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Background Dalbergia sissoo DC. (Family: Fabaceae) is a medium to large deciduous tree, is locally called “shishu” in Bangladesh. It is used to treat sore throats, dysentery, syphilis, bronchitis, inflammations, infections, hernia, skin diseases, and gonorrhea. This study evaluated the antinociceptive effect of the methanol extract of D. sissoo leaves (MEDS) in mice.MethodsThe extract was assessed for antinociceptive activity using chemical and heat induced pain models such as hot plate, tail immersion, acetic acid-induced writhing, formalin, glutamate, and cinnamaldehyde test models in mice at the doses of 100, 200, and 400 mg/kg (p.o.) respectively. Morphine sulphate (5 mg/kg, i.p.) and diclofenac sodium (10 mg/kg, i.p.) were used as reference analgesic drugs. To confirm the possible involvement of opioid receptor in the central antinociceptive effect of MEDS, naloxone was used to antagonize the effect.ResultsMEDS demonstrated potent and dose-dependent antinociceptive activity in all the chemical and heat induced mice models (p < 0.001). The findings of this study indicate that the involvement of both peripheral and central antinociceptive mechanisms. The use of naloxone verified the association of opioid receptors in the central antinociceptive effect.ConclusionsThis study indicated the peripheral and central antinociceptive activity of the leaves of D. sissoo. These results support the traditional use of this plant in different painful conditions.

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“…Its antinociceptive effect is at the dose of 50 mg/kg. In our study, antinociceptive effect of caper was at the dose of 100 mg/kg (18). It is argued that the main cause of orofacial pain is the release of inflammatory mediators in the region.…”

Section: Discussionmentioning

confidence: 53%

Pain modulation and Histopathological effects of the Hydroalcoholic extract of Capparis spinosa on mice model of Orofacial formalin test: an experimental study

Rayyani¹,

Seifi²,

Askian³

et al. 2019

Electron. physician

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Background: Orofacial pain is a form of inflammatory pain usually treated with corticosteroids, which have many side effects. Objective: The aim of this study was to investigate the clinical and histological profile of antinociceptive effects of hydroalcoholic extract of caper (Capparis spinosa) for the first time in the orofacial region. Methods: This experimental study was carried out at Babol University of Medical Sciences in 2018. Thirty-six male Wistar mice were divided into 6 groups: The first group received saline, the second group received dexamethazone, and four groups received different doses (10, 20, 50, 100 mg/kg) of caper extract. In the formalin test, 1% formalin solution was injected into the right submucosal layer of the lip and lateral area of the nose. Pain intensities were recorded at 5-min blocks for 60 min after injection. Dose effect of caper on pain was recorded. The mice were euthanized and the oral area was biopsied and stained with Hematoxylin-eosin, Toluidine blue, and Congo red. Data were analyzed using repeated measures ANOVA and t-test by IBM-SPSS version 20. Results: Caper produced antinociceptive effects in comparison with saline groups (p<0.001). Dose effect on pain was significant (p<0.001). The highest antinociceptive effect was observed in the caper group receiving 100 mg/kg of agent 15-20 minutes after injection. The highest pain level was observed in the group that received 20 mg/kg of caper (p<0.001). Dexamethazone antinociceptive effect was greater than that of the saline and the dose of 20 mg/kg of caper (p<0.001). Antinociceptive effects in two groups (100 mg caper and dexamethazone) were equal (p>0.999). Histopathologic examination revealed the highest thickness of epithelium, fibrous, and muscular tissue density and the lowest inflammatory infiltration at the dose of 100 mg/kg of caper. Conclusion:The results of the present study suggest that hydroalcoholic extract of caper possesses antinociceptive activity in a dose-dependent manner and caper-induced antinociception might be mediated, at least in part, by anti-inflammatory effects.

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Antinociceptive effect of methanol extract ofCapparis ovatain mice

Abstract: Based on the results obtained, it can be concluded that CME is a potentially antinociceptive agent which acts as both at the peripheral and central levels.

Cited by 33 publications

References 25 publications

Evaluation of antinociceptive activity of hydromethanol extract of Cyperus rotundus in mice

Evaluation of antinociceptive activity of hydromethanol extract of Cyperus rotundus in mice

Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice

Pain modulation and Histopathological effects of the Hydroalcoholic extract of Capparis spinosa on mice model of Orofacial formalin test: an experimental study

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