Antinociceptive Effects of Bee Venom Acupuncture (Apipuncture) in Rodent Animal Models: A Comparative Study of Acupoint Versus Non-Acupoint Stimulation

Prolonged analgesic effect of PLGA-encapsulated bee venom on formalin-induced pain in rats

“…In the BV acupuncture treatment, BV injection is conducted to stimulate an acupuncture point as well as to exert pharmacological effects by the biologically active compounds in BV (Kwon et al, 2001a). Although BV acupuncture therapy is relevant to treating various chronic pain diseases in Korean traditional medicine, the treatment sometimes results in erythema and eventually edema and pain, because of allergenic components in BV.…”

Bee venom modulates murine Th1/Th2 lineage development

“…Melittin and phospholipase A 2 are the two major ingredients thought to be responsible for inducing irritation and the well known allergic reaction associated with bee stings. Several studies demonstrated that BV administration in the cat or rat animal model produced prolonged and tonic nociceptive responses [2][3][4][5][6][7]. Additionally, this analgesic effect seems to be significantly enhanced by BV injection into specific anatomical locations, so called acupoints [8].…”

Bee Venom Acupuncture for Musculoskeletal Pain: A Review

“…23,24,27,32 Clinical effects in human patients have been reported against arthritis, neuralgia, and chronic inflammation. 15,16,32 A recently published overview of data from 6 human studies [2 randomized clinical trials (RCTs) and 4 uncontrolled studies] concluded that there is limited evidence of the efficacy of BVA against arthritis.…”