Antinociceptive effects of ethanolic extract from the flowers of Acmella oleracea (L.) R.K. Jansen in mice

Nomura, Ellen Cristine Ogata; Rodrigues, Melissa Raboni Alves; Silva, Carla Francielle da; Hamm, Letícia Alencar; Nascimento, Adamara Machado; Souza, Lauro Mera de; Cipriani, Thales R.; Baggio, Cristiane Hatsuko; Werner, Maria Fernanda de Paula

doi:10.1016/j.jep.2013.09.007

Cited by 81 publications

(32 citation statements)

References 33 publications

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“…After 8 weeks of alloxan-induced diabetes, the mice showed evidence of thermal hyperalgesia (8.49 ± 0.19 S at baseline to 4.80 ± 0.20 S in hot plate latency and 5.29 ± 0.02 S at baseline to 2.16 ± 0.02 S in tail flick latency) and mechanical allodynia (9.10 ± 0.20 g at baseline to 2.55 ± 0.19 g using Von Frey filaments), comparable to those illustrated before in literature [12,20,29,30]. We investigated the antinociceptive potentials of AC, SARF, and compound 3 against hot plate and tail flick thermal hyperalgesia.…”

Section: Groupsupporting

confidence: 89%

“…However, the highest dose of AC showed more amelioration of tactile allodynia than those of SARF and compound 3. Thus, AC showed more powerful antinociceptive activity against thermal hyperalgesia and mechanical allodynia than its most active fraction (SARF) and constituent glaucine (3), showing that there is an apparent additive effect between AC constituents potentiating its activity as concluded before in literature [12,20,29,30].…”

Section: Groupsupporting

confidence: 53%

“…DN is a common complication of T1DM and may cause serious pain. This pain might happen spontaneously, as hyperalgesia associated with mild painful stimuli, or as allodynia with non-noxious stimuli [12].…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical and Antinociceptive Investigations of Anemone coronaria Active Part Ameliorating Diabetic Neuropathy Pain

Raafat

El-Lakany

2018

PMIO

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Phytochemicals might offer economic therapies, which are an alternative especially for low-income developing countries. Anemone coronaria has been used extensively as antineuralgic and antirheumatic in the folk medicine of Lebanon. Thus, the aim of this study was to investigate the antinociceptive potential of A. coronaria and its active principles against diabetic-neuropathy pain in a mouse-model. The study also aimed to achieve a bio-guided fractionation and to isolate the most active principles in A. coronaria herb. Bio-guided fractionation used reversed phase-HPLC, and 1H and 13C NMR for the identification of the most active fraction of A. coronaria, which was rich in alkaloids. This isolated alkaloid rich fraction contained catalin (21.1%), thaliporphine (14.1%), and glaucine (compound 3) (63.4%). A. coronaria extract (50, 100, and 200 mg/kg), the isolated alkaloid rich fraction (70 mg/kg), and glaucine (25, 50, and 100 mg/kg) showed significant reduction in acute and subchronic hyperglycemia, with significant increase in glutathione and catalase levels, along with normalization of HbA1c and LPO levels (n=7 per group, p≤0.05). A. coronaria extract (50, 100, and 200 mg/kg), the isolated alkaloid rich fraction (70 mg/kg), and glaucine (25, 50, and 100 mg/kg) also showed significant antinociceptive amelioration in thermal hyperalgesia pain latencies utilizing hot plate and tail flick tests. The highest doses of A. coronaria extract (200 mg/kg), isolated alkaloid rich fraction (70 mg/kg), and glaucine (100 mg/kg) showed a significant elevation in mechanical allodynia pain thresholds using Von-Frey-filaments. The results revealed that A. coronaria herb along with its most active alkaloid rich fraction and constituent (glaucine) possessed significant antihyperglycemic and antinociceptive potentials. These findings may lead to a future use of A. coronaria in the management of diabetic-neuropathy pain.

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Section: Groupsupporting

confidence: 89%

Section: Groupsupporting

confidence: 53%

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Phytochemical and Antinociceptive Investigations of Anemone coronaria Active Part Ameliorating Diabetic Neuropathy Pain

Raafat

El-Lakany

2018

PMIO

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“…Tacacá is in greatest demand during festival periods, such as Círio de Nazaré and for end-of-year parties (GUSMÃO; GUSMÃO, 2013;SAMPAIO et al, 2018). In addition to its use in local cuisine, it A. oleracea is widely used in folk medicine due to its analgesic, anti-inflammatory and anesthetic properties (NOMURA et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…A maior demanda da cultura é durante os períodos festivos, como o Círio de Nazaré e festas de final de ano (GUSMÃO; GUSMÃO, 2013;SAMPAIO et al, 2018). Além do uso na culinária local, é uma espécie muito utilizada na medicina popular devido sua ação analgésica, anti-inflamatória e anestésica (NOMURA et al, 2013).…”

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Influence of temperature on the germination and root size of Acmella oleracea (L.) R. K. Jansen

Silva¹,

Sampaio²,

Bittencourt³

et al. 2020

AGRO@MBIENTE ON-LINE

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Acmella oleracea is a herbaceous plant native to the Amazon region that is currently arousing industrial interest due to its potential gastronomic, cosmetic and pharmaceutical uses. Accordingly, the objective of the current study was to test the influence of temperatures on A. oleracea seed germination and seedling vigor. A completely randomized design (CRD) with five treatments and five replicates was used. Treatments consisted of temperatures: 23, 26, 29, 32 and 35 ºC. The study was conducted in BODtype climate chambers with relative humidity above 90% and a 12 h photoperiod. Germination, germination speed index (GSI), average germination time, root length and number of normal and abnormal seedlings were recorded. Temperature influenced all analyzed variables, except average germination time and number of normal/abnormal seedlings. A quadratic model best described the relationship between dependent and independent variables. In general, maximum germination values, and GSI and root lengths were obtained at temperatures close to 29 °C, while the lowest observed values for these variables occurred at extreme temperatures (23 and 35 °C). The highest percentage of germinated seeds occurred on the second day. Temperatures above 29 ºC induced a significant reduction in the A. oleracea seedling root lengths.

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Morphological alterations in the ovaries of Amblyomma cajennense semi‐engorged ticks exposed to ethanolic extract of Acmella oleracea

Anholeto

Oliveira

Rodrigues

et al. 2018

Microscopy Res & Technique

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The present study analyzed the effects of different concentrations of Acmella oleracea crude ethanolic extract (EEAO) on the development of germ cells from semi-engorged Amblyomma cajennense females in order to evaluate the potential of this natural chemical as a strategy to control these important ectoparasites. A hundred semi-engorged females were divided into five groups (duplicates) (10 animals/group): Control 1 (distilled water); Control 2 (solvent ethanol 50% and DMSO 1%); and Treatment I to III (3.1, 6.2, and 12.5 mg/mL of EEAO, respectively).For the exposure of the ticks to the extract was used the Adult Immersion Test. After the exposition, the ovaries were removed and submitted to histological analysis using Harris hematoxylin and aqueous eosin. The histochemical tests were performed using PAS and Bromophenol blue staining techniques, for the detection of total polysaccharides and total protein, respectively.The extract caused significant alterations in the oocytes, including changes in the shape of the cells, disorganization, and cytoplasmic vacuolation, decrease in the number of yolk granules and germ vesicle fragmentation. These alterations were more intense in the oocytes in initial developmental stages (I and II). The results obtained in this study confirm the cytotoxic potential of the ethanolic extract of A. oleracea on the germ cells of A. cajennense females, opening up the possibility to use this extract as an alternative to control these ectoparasites.

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Antinociceptive effects of ethanolic extract from the flowers of Acmella oleracea (L.) R.K. Jansen in mice

Cited by 81 publications

References 33 publications

Phytochemical and Antinociceptive Investigations of Anemone coronaria Active Part Ameliorating Diabetic Neuropathy Pain

Phytochemical and Antinociceptive Investigations of Anemone coronaria Active Part Ameliorating Diabetic Neuropathy Pain

Influence of temperature on the germination and root size of Acmella oleracea (L.) R. K. Jansen

Morphological alterations in the ovaries of Amblyomma cajennense semi‐engorged ticks exposed to ethanolic extract of Acmella oleracea

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