Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors

Jin, Wu-Yang; Liu, Zhuo; Liu, Dong; Yu, Long-Chuan

doi:10.1016/j.brainres.2009.12.060

Cited by 38 publications

(40 citation statements)

References 32 publications

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“…In this context, it should be also recalled that galanin antagonizes substance P-evoked hyperalgesia (23,70; see Ref. 69 also for further references) and that its antinociceptive effects involve opioid receptors and display positive interactions with NMDA receptor antagonists (22,25,62,66; see Ref. 69 also for further references).…”

Section: Discussionmentioning

confidence: 99%

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Inhibitory control of the cough reflex by galanin receptors in the caudal nucleus tractus solitarii of the rabbit

Mutolo

Cinelli

Bongianni

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

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The caudal nucleus tractus solitarii (NTS) is the main central station of cough-related afferents and a strategic site for the modulation of the cough reflex. The similarities between the characteristics of central processing of nociceptive and cough-related inputs led us to hypothesize that galanin, a neuropeptide implicated in the control of pain, could also be involved in the regulation of the cough reflex at the level of the NTS, where galanin receptors have been found. We investigated the effects of galanin and galnon, a nonpeptide agonist at galanin receptors, on cough responses to mechanical and chemical (citric acid) stimulation of the tracheobronchial tree. Drugs were microinjected (30 -50 nl) into the caudal NTS of pentobarbital sodium-anesthetized, spontaneously breathing rabbits. Galnon antitussive effects on cough responses to the mechanical stimulation of the airway mucosa via a custom-built device were also investigated. Bilateral microinjections of 1 mM galanin markedly decreased cough number, peak abdominal activity, and increased cough-related total cycle duration. Bilateral microinjections of 1 mM galnon induced mild depressant effects on cough, whereas bilateral microinjections of 10 mM galnon caused marked antitussive effects consistent with those produced by galanin. Galnon effects were confirmed by using the cough-inducing device. The results indicate that galanin receptors play a role in the inhibitory control of the cough reflex at the level of the caudal NTS and provide hints for the development of novel antitussive strategies. airway defensive reflexes; galanin; galanin receptors; galnon; nucleus tractus solitarii COUGH IS A VERY IMPORTANT airway protective reflex and is one of the most common reason why patients seek medical attention. Cough is purposeful and useful under many circumstances, but in case of persistent or chronic cough (e.g., 15) is without an apparent aim and benefit and can results in a wide range of physical and psychological complications including urinary incontinence, insomnia, depression, and anxiety. The efficacy of antitussive drugs is far from clear from the available evidence and, in addition, limited by important side effects. Therefore, further research to find better antitussive approaches is necessary (for reviews see Refs. 4 and 15). Studies undertaken to provide insights into the neural mechanisms subserving the cough reflex may also provide useful suggestions for novel antitussive therapeutic strategies. The cough reflex involves several brain stem structures that also underlie respiratory rhythm generation (e.g., 7,9,10,19,24,27,[47][48][49]55).In particular, the nucleus tractus solitarii (NTS), especially in its caudal aspects, is the main central terminus of cough-related afferents (14, 39 -41, 43, 53 also for further references) and, in addition, a possible strategic site of synaptic plasticity, where cough-related sensory inputs can be modulated (e.g., 10,14,34,39,40,43).In recent years, we and other researchers have focused our attention on the s...

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Section: Discussionmentioning

confidence: 99%

“…Only one of these drugs was tested in each preparation unless otherwise stated. Microinjections of galanin and galnon with similar concentrations have been performed in previous studies in in vivo preparations (1,25,52,62,68). Galanin was dissolved in 0.9% NaCl solution.…”

Section: Microinjection Proceduresmentioning

confidence: 99%

Inhibitory control of the cough reflex by galanin receptors in the caudal nucleus tractus solitarii of the rabbit

Mutolo

Cinelli

Bongianni

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Similarly, administration of high doses of galanin into the ARC decreases nociception by a PKC-and opioiddependent mechanism, probably by influencing the PAG Sun et al, 2003Sun et al, , 2007Sun and Yu, 2005). Administration of galanin into the central nucleus of the amygdala (possibly by a GAL 1 -and opioid-dependent mechanism) (Jin et al, 2010), the tuberomammillary nucleus (Sun et al, 2004), and the nucleus accumbens (Xu et al, 2012a) decreases painrelated behaviors. These effects are inhibited by the putative galanin receptor antagonist galantide, which blocks all galanin receptors.…”

Section: Painmentioning

confidence: 99%

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

Lang

Gundlach

Holmes

et al. 2015

Pharmacological Reviews

276

310

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“…functions, such as pain regulation, learning and memory, osmotic equilibrium, nerve injury and nerve protection, food intake and metabolism, anxiety-like behavior regulation (Cheng and Yu 2010;Gu et al 2007;Hua et al 2004;Jimenez-Andrade et al 2006;Jin et al 2010;Wang et al 2000;Wu and Yu 2006). Many studies demonstrated that galanin induced significant antinociceptive effects in the spinal cord, as well as in the brain (Gu et al 2007;Hua et al 2004;Jin et al 2010;Fu et al 2011;Liu and Hökfelt 2002).…”

mentioning

confidence: 98%

“…Many studies demonstrated that galanin induced significant antinociceptive effects in the spinal cord, as well as in the brain (Gu et al 2007;Hua et al 2004;Jin et al 2010;Fu et al 2011;Liu and Hökfelt 2002).…”

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confidence: 99%

Antinociceptive effects induced by intra-lateral habenula complex injection of the galanin receptor 1 agonist M617 in rats

et al. 2015

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The present study was performed to explore the antinociceptive effects of the galanin receptor 1 agonist M617 in lateral habenula complex in rats. Intra-lateral habenula injection of 0.1, 0.5, 1 or 2 nmol of galanin induced dose-dependent increases in hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulations in rats. Furthermore, intra-lateral habenula injection of 0.1, 0.5, 1 or 2 nmol of the galanin receptor 1 agonist M617 also induced dose-dependent increases in HWLs to noxious thermal and mechanical stimulations in rats. Interestingly, there were no significant differences between the antinociceptive effects induced by intra-lateral habenula injection of 2 nmol of M617 and 2 nmol of galanin. The results indicate that galanin receptor 1 may be involved in the galanin-induced antinociceptive effects in the lateral habenula.

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Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors

Cited by 38 publications

References 32 publications

Inhibitory control of the cough reflex by galanin receptors in the caudal nucleus tractus solitarii of the rabbit

Inhibitory control of the cough reflex by galanin receptors in the caudal nucleus tractus solitarii of the rabbit

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

Antinociceptive effects induced by intra-lateral habenula complex injection of the galanin receptor 1 agonist M617 in rats

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