Antinociceptive properties of ethanolic extract and fractions of Pterodon pubescens Benth. seeds

Coelho, Luciana P.; Reis, Patrícia Alves; Castro, Fernanda Lima de; Gayer, Carlos Roberto Machado; Lopes, Carlos da Silva; Silva, Maria Cristina da Costa e; Sabino, Kátia Costa de Carvalho; Todeschini, Adriane R.; Coelho, Marsen Garcia Pinto

doi:10.1016/j.jep.2005.01.014

Cited by 76 publications

(74 citation statements)

References 26 publications

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“…The oil extracted from the fruit of the Pterodon sp. has been shown to have several pharmacological properties including anticancer, antinociceptive, and anti-inflammatory activity, and has been studied mainly for its effects on arthritis (Carvalho et al, 1999;Coelho et al, 2005;Vieira et al, 2008;Hoscheid et al, 2013). The raw oil extract is difficult to use in pharmaceutical preparations without protection of its lipophilic constituents, which are easily oxidized by exposure to air and light.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of microcapsules of Pterodon pubescens Benth. by using natural polymers

Reinas¹,

Hoscheid²,

Outuki³

et al. 2014

Braz. J. Pharm. Sci.

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An oleaginous fraction obtained from an alcohol extract of the fruit of Pterodon pubescens Benth. (FHPp) was microencapsulated in polymeric systems. These systems were developed using a complex coacervation method and consisted of alginate/medium-molecular-weight chitosan (F1-MC), alginate/ chitosan with greater than 75% deacetylation (F2-MC), and alginate/low-molecular-weight chitosan (F3-MC). These developed systems have the potential to both mask the taste of the extract, and to protect its constituents against possible chemical degradation. The influence of the formulation parameters and process were determined by chemical profiling and measurement of the microencapsulation efficiency of the oleaginous fraction, and by assessment of microcapsule morphology. The obtained formulations were slightly yellow, odorless, and had a pleasant taste. The average diameters of the microcapsules were 0.4679 µm (F2-MC), 0.5885 µm (F3-MC), and 0.9033 µm (F1-MC). The best formulation was F3-MC, with FHPp microencapsulation efficiency of 61.01 ± 2.00% and an in vitro release profile of 75.88 ± 0.45%; the content of vouacapans 3-4 was 99.49 ± 2.80%. The best model to describe the release kinetics for F1-MC and F3-MC was that proposed by Higuchi; however, F2-MC release displayed firstorder kinetics; the release mechanism was of the supercase II type for all formulations.Uniterms: Pterodon pubescens Benth./pharmacognosy. Sucupira. Microcapsules/preparation. Vouacapans. Alginate. Chitosan. Coacervation method. Natural polymers. Natural products.Uma fração oleaginosa obtida do extrato etanólico de frutos de Pterodon pubescens Benth (FHPp) foi microencapsulada em um sistema polimérico. Estes sistemas foram desenvolvidos utilizando o método de coacervação complexa, constituído de alginato/quitosana massa molecular média (F1-MC), alginato/ quitosana com desacetilação superior a 75% (F2-MC) e alginato/quitosana de massa molecular baixa (F3-MC). Estes sistemas desenvolvidos têm o potencial tanto de mascarar o sabor do extrato, quanto de protegê-lo de possível degradação química. A influência dos parâmetros de formulação e processo foram determinadas por caracterização química, determinação da eficiência de microencapsulação da fração oleaginosa e por avaliação morfológica da microcápsula. As formulações mostraram-se ligeiramente amareladas, inodoras e com sabor agradável. Os diâmetros médios das microcápsulas foram de 0,4679 µm (F2-MC), 0,5885 µm (F3-MC) e 0,9033 µm (F1-MC). A melhor formulação foi F3-MC, considerando-se que apresentou eficiência de encapsulação de 61,01 ± 2,00%, e perfil de liberação in vitro de 75,88 ± 0,45%; o conteúdo dos vouacapanos 3-4 foi 99,49 ± 2,80%. O melhor modelo para descrever a cinética de liberação foi o modelo proposto por Higuchi para F1-MC e F3-MC, entretanto, para F2-MC foi o modelo de primeira ordem, e o mecanismo de liberação foi do tipo super caso II para todas as formulações.Unitermos: Pterodon pubescens Benth./farmacognosia. Sucupira. Microcápsulas/preparação. Vouacapanos. Alginato. Quitosana. ...

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of microcapsules of Pterodon pubescens Benth. by using natural polymers

Reinas¹,

Hoscheid²,

Outuki³

et al. 2014

Braz. J. Pharm. Sci.

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“…In subsequent work, sub-acute toxic effects were not observed with hydro-alcoholic extract in studies of hematological, histopathological, clinical, and biochemical parameters in arthritic mice, according to studies of Coelho et al (2001). Further analysis revealed the anti-inflammatory (Silva et al, 2004) and anti-nociceptive effects of ethanolic extracts of P. pubescens seeds, confirming the rationale behind the use of this plant in popular medicine to treat pain disorders (Coelho et al, 2005) (Table I). The investigations on the pharmacological properties of 'sucupira' surpass those of its anti-inflammatory and anti-rheumatic activities.…”

Section: Biological Propertiesmentioning

confidence: 56%

“…There are several papers referring to the isolation of alkaloid molecules of the Pterodon genus (Sabino et al, 1999a;Coelho et al, 2005;Dutra et al, 2008a,b;Menna-Barreto et al, 2008;Vieira et al, 2008;Dutra et al, 2009b) but only one paper showed the structures of homoormosanine-type alkaloids from Bowdichia virgiloides, popularly called 'black sucupira' or 'sucupira preta' (Torrenegra et al, 1989).…”

Section: Chemistrymentioning

confidence: 99%

“…Although the 'sucupira' seeds are commercially available at the medicinal flora market and are widely used in domestic medicine for their anti-rheumatic (Sabino et al, 1999b;Coelho et al, 2004), analgesic (Coelho et al, 2005) and anti-inflammatory (Carvalho et al, 1999;Dutra et al, 2009) properties, only a small number of papers have described the various flavonoids, amino-containing, triterpene, steroid, and others secondary compounds present in the Pterodon genus. In addition, to the best of our knowledge, there is only one report available in the literature showing studies with proteins isolated from this genus, a 5 kDa α-amylase inhibitor reported by Silva et al (2007).…”

Section: Introductionmentioning

confidence: 99%

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Pharmaceutical properties of 'sucupira' (Pterodon spp.)

Hansen

Haraguchi

Alonso

2010

Braz. J. Pharm. Sci.

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The plant of the genus Pterodon (Fabaceae, Leguminosae), commonly known as 'sucupira' or 'faveira', are disseminated throughout the central region of Brazil and has frequently been used in popular medicine for its anti-rheumatic, analgesic, and anti-inflammatory properties. In recent years, interest in these plants has increased considerably. The biological effects of different phytoextracts and pure metabolites have been investigated in several experimental models in vivo and in vitro. The literature describes flavonoids, triterpene and steroids, while one paper presented studies with proteins isolated from the genus. This review provides an overview of phytochemical and pharmacological research in Pterodon, showing the main chemical compounds studied to date, and focusing on the relationship between these molecules and their biological activity. Furthermore, this study paves the way for more in-depth investigation, isolation and characterization of the molecules of this plant genus.Uniterms: Sucupira. Pterodon/phytochemistry. Pterodon/pharmacognosy. Diterpenes/biological activity. Isoflavones/biological activity. Medicinal plants.As plantas do gênero Pterodon (Fabaceae/Leguminosae), conhecidas popularmente como "sucupira branca" ou "faveira", encontram-se distribuídas pela região central do Brasil e são frequentemente utilizadas na medicina popular por suas propriedades antirreumáticas, analgésicas e antiinflamatórias. Nos últimos anos, o interesse por estas plantas tem aumentado consideravelmente. Os efeitos biológicos dos diferentes fitoextratos e metabólitos puros têm sido investigados em vários modelos experimentais in vivo e in vitro. A literatura descreve flavonóides, triterpenos, esteróides e apenas um trabalho mostra estudos com proteínas isoladas do gênero. Esta revisão apresenta de maneira geral as investigações farmacológicas e fitoquímicas de Pterodon, mostrando os principais compostos já estudados, sua composição química, focando na relação entre estas moléculas e sua atividade biológica. Mais ainda, nós abrimos as portas para maior investigação, isolamento e caracterização de moléculas deste gênero de plantas.Unitermos: Sucupira. Pterodon/fitoquímica. Pterodon/farmacognosia. Diterpenos/atividade biológica. Isoflavonas/atividade biológica. Plantas medicinais.

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“…P. emarginatus pertence à família Fabaceae (= Leguminosae), subfamília Faboideae, e é conhecida popularmente como "sucupira", "sucupira-branca" ou "faveira". As sementes dessa planta são amplamente utilizadas com ϐins medicinais em função de suas ações antirreumáticas (Coelho et al 2004), analgésicas (Coelho et al 2005), antimicrobiana (Santos et al 2010), anticercária (Mahajan & Monteiro 1970), anti-inϐlamatória (Mors et al 1967) e no tratamento de faringites, amidalites e bronquites em humanos. Outra importante utilidade da espécie é na indústria madeireira (Lorenzi 2008).…”

Section: Introductionunclassified

Intoxicação espontânea por Pterodon emarginatus (Fabaceae) em bovinos no estado de Goiás

Sant’Ana

Perin²,

Bilego³

et al. 2012

Pesq. Vet. Bras.

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Pesq. Vet. Bras. 32(6) santanaϐjf@yahoo.com An outbreak of poisoning by Pterodon emarginatus in cattle in Goiás, Brazil, is described. Eighty four cattle that accidentally consumed the leaves and fruits from a P. emarginatus tree, fallen in a storm, were affected and seven died. Clinical signs included piloerection, ϐlank retraction, marked apathy, prostration, muscle tremors, muzzle dryness, tenesmus, incoordination, reluctance to move, and prolonged sternal recumbency. AST, ALT, and GGT serum activity, and bilirubin levels were markedly increased. Gross lesions included hepatomegaly, multifocal areas of necrosis in the liver, and hemorrhages in the heart, parietal pleura, mesentery, omentum, ruminal serosa, spleen, lung, subcutaneous tissue, and thoracic and intercostal skeletal muscles. Histologically, moderate to severe, massive hepatocellular degeneration and necrosis with moderate bile duct hyperplasia and mild bile stasis were observed. In addition, moderate multifocal vacuolar degeneration in the convoluted renal tubular cells was noted. 4 Setor de Cirurgia de Grandes Animais, Universidade Federal de Goiás, Campus Jataí, BR 364 Km 192, Jataí, GO.5 Laboratório de Anatomia, CAJ-UFG, Jataí, GO. 6 Acadêmico de Medicina Veterinária, LPV/CAJ-UFG, Jataí, GO. Bolsista Probec/UFG. em movimentar-se e decúbito esternal prolongado. As atividades séricas de AST, ALT e GGT e os teores de bilirrubina estavam acentuadamente elevados. As principais alterações macroscópicas consistiam de hepatomegalia e áreas multifocais de necrose no ϐígado, além de hemorragias no coração, pleura parietal, mesentério, omento, serosa do rúmen, baço, pulmão, subcutâneo e musculatura esquelé-tica intercostal e torácica. Microscopicamente, observou-se degeneração e necrose hepatocelular massiva moderada a acentuada, hiperplasia biliar multifocal moderada e bilestase multifocal leve. Adicionalmente, notou-se degeneração vacuolar multifocal moderada nos túbulos contorcidos dos rins.TERMOS DE INDEXAÇÃO: Plantas tóxicas, Pterodon emarginatus, Fabaceae, sucupira, sucupira-branca, faveira, intoxicação por plantas, bovinos. INTRODUÇÃOPterodon emarginatus Vogel (sin. Pterodon pubescens Benth.) é uma espécie arbórea, aromática, nativa do cerrado brasileiro e de sua transição para a ϐloresta semidecídua,

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Antinociceptive properties of ethanolic extract and fractions of Pterodon pubescens Benth. seeds

Cited by 76 publications

References 26 publications

Preparation and characterization of microcapsules of Pterodon pubescens Benth. by using natural polymers

Preparation and characterization of microcapsules of Pterodon pubescens Benth. by using natural polymers

Pharmaceutical properties of 'sucupira' (Pterodon spp.)

Intoxicação espontânea por Pterodon emarginatus (Fabaceae) em bovinos no estado de Goiás

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